The document discusses the acetate melonate pathway, which involves the synthesis of fatty acids and aromatic compounds through secondary metabolites. It uses acetyl-CoA and malonyl-CoA as precursors to form fatty acyl thioesters on acyl carrier protein. These thioesters are important intermediates that can be further processed into saturated or unsaturated fatty acids, polyketides, and aromatic compounds through downstream pathways. The pathway contributes to the formation of approximately one third of known secondary metabolites.

1. ACETATE MELONATE
PATHWAY
Presented By:
Sachin Kumar
B. Pharm 3rd Year
PSIT (PHARMCY), Kanpur

2. INTRODUCTION
• Acetate pathway operates with the involvement of acyl carrier protein (ACP) to
yield fatty acyl thioesters of ACP. These acyl thioesters forms the important
intermediates in fatty acid synthesis.
• The pathway contain mainly two route:
(i) Acetate Mevalonate Pathway
(ii) Acetate Melonate Pathway
• Its contributes one third known secondary metabolites.

3. ACETATE MELONATE PATHWAY
• Acetate-Melonate pathway includes synthesis of Fatty acids and Aromatic
compounds with the help of secondary metabolites.
• Main precursors of Acetate-Melonate Pathway are Acetyl-CoA and Malonyl-CoA
.
• End products of this pathway can be saturated or unsaturated fatty acids or
polyketides
• Polyketides are secondary metabolites which further synthesize Aromatic
compounds by polyketide pathway.

4. PRECURSORS
• Acetyl-CoA (Starter Unit) • Malonyl-CoA (Extender Unit)

5. Acetyl- CoA
Malonyl- ACP
Acetyl CoA carboxylase
Acetyl- ACP
Acetoacetyl- ACP
Malonyl- CoA
Acetyl transferase ACP ACP Malonyl transferase
NADPH
Palmitoyl
ACP
Stearoyl ACP
Oleloyl ACP
TRIGLYCERIDE
S
Palmitic Acid
Stearic Acid
Oleic Acid
Linoleic acid
Linolenic acid
Arachidonic acid