IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Epidemiology and recent advances in leprosy Bhavna Jain
Leprosy is a major public health problem in India and the World. Despite of having many programs to eliminate it, India is sharing a major burden of this disease. To understand this problem and the present measures adopted this presentation has been created.
Epidemiology and recent advances in leprosy Bhavna Jain
Leprosy is a major public health problem in India and the World. Despite of having many programs to eliminate it, India is sharing a major burden of this disease. To understand this problem and the present measures adopted this presentation has been created.
This ppt contains all the information about the Epidemiology of leprosy. It is useful for students of the medical field learning Preventive and social medicine, Swasthavritta (Ayurved), and everyone who is interested in knowing about it
Kyasanur forest disease, KFD is a febrile disease associated with haemorrhage caused by kyasanur forest disease virus, a member of virus family of arbovirus & flavivirus and transmitted to man by bite of infected ticks.
—Fungal organisms are ubiquitous. A common location for these organisms to enter the human body is through the external acoustic canal, oral cavity, and pharynx and sino-nasal cavity. A study was conducted with clinical and mycological analysis of various fungal infections in ENT. Patients suspected for having fungal infections attending at Department of ENT were interrogated and analysed. Swabs collected from these cases were sent for direct microscopy by KOH mounts for fungal examination and fungal culture. Microbiological confirmed 100 cases were finally included in the study Histopathological examination of nasal mass and polyposis was also done. It was observed in this present study otomycosis was most common and accounted for 84% of the total cases followed by candidiasis in oral cavity and pharynx in 9%, allergic fungal rhinosinusitis in 4% and rhinosporidiosis in 3%. Aspergillus niger was that most common fungus isolated in 61% cases, followed by Candida albicans in 24% cases, Aspergillus flavus in 9% cases, Aspergillus fumigatus and Rhinosporodium seeberi in 3% cases each. All the cases of fungal infection of oral cavity and oropharynx were due to Candida albicans.
Japanese encephalitis - Sep 2019 India epidemiology - Is vaccination needed?Gaurav Gupta
IAP Chandigarh Meeting presentation on a Panel Discussion on the need for JE vaccination in Indian situation, especially for private practitioners in and around Chandigarh, North India
Dengue is caused by an virus named as Den of 4 serotypes. Den virus is being spread by a mosquito Aedes aegypti. It is very essential to understand symptoms of dengue, habit, habitat and life cycle of vector Aedes. There by Dengue control measures can be taken to control dengue diseases to prevent morbidity and mortality due to dengue.
This paper discusses some of the major steps, factors and issues that need to be considered in
planning for and implementing distance education programs.
Levy explained that The Internet and the World Wide Web , have made the process of obtaining an education
without regard to time or location easier for the student. At the same time, they have provided more challenges
for the colleges providing this education. In online distance learning, not only does the instruction occur via a
computer system, usually over the Internet, but other educational processes occur via the computer as well.
These educational processes are student services, training, and support. The transition to online distance
learning, primarily driven by social change, is creating a paradigm shift in the way colleges are viewing
teaching and learning (Rogers, 2000). Administrators, faculty, staff, and students realize that in order to
successfully implement ODL, their colleges will need to reassess their programs (levy,retrieved,Apr,2013).
This ppt contains all the information about the Epidemiology of leprosy. It is useful for students of the medical field learning Preventive and social medicine, Swasthavritta (Ayurved), and everyone who is interested in knowing about it
Kyasanur forest disease, KFD is a febrile disease associated with haemorrhage caused by kyasanur forest disease virus, a member of virus family of arbovirus & flavivirus and transmitted to man by bite of infected ticks.
—Fungal organisms are ubiquitous. A common location for these organisms to enter the human body is through the external acoustic canal, oral cavity, and pharynx and sino-nasal cavity. A study was conducted with clinical and mycological analysis of various fungal infections in ENT. Patients suspected for having fungal infections attending at Department of ENT were interrogated and analysed. Swabs collected from these cases were sent for direct microscopy by KOH mounts for fungal examination and fungal culture. Microbiological confirmed 100 cases were finally included in the study Histopathological examination of nasal mass and polyposis was also done. It was observed in this present study otomycosis was most common and accounted for 84% of the total cases followed by candidiasis in oral cavity and pharynx in 9%, allergic fungal rhinosinusitis in 4% and rhinosporidiosis in 3%. Aspergillus niger was that most common fungus isolated in 61% cases, followed by Candida albicans in 24% cases, Aspergillus flavus in 9% cases, Aspergillus fumigatus and Rhinosporodium seeberi in 3% cases each. All the cases of fungal infection of oral cavity and oropharynx were due to Candida albicans.
Japanese encephalitis - Sep 2019 India epidemiology - Is vaccination needed?Gaurav Gupta
IAP Chandigarh Meeting presentation on a Panel Discussion on the need for JE vaccination in Indian situation, especially for private practitioners in and around Chandigarh, North India
Dengue is caused by an virus named as Den of 4 serotypes. Den virus is being spread by a mosquito Aedes aegypti. It is very essential to understand symptoms of dengue, habit, habitat and life cycle of vector Aedes. There by Dengue control measures can be taken to control dengue diseases to prevent morbidity and mortality due to dengue.
This paper discusses some of the major steps, factors and issues that need to be considered in
planning for and implementing distance education programs.
Levy explained that The Internet and the World Wide Web , have made the process of obtaining an education
without regard to time or location easier for the student. At the same time, they have provided more challenges
for the colleges providing this education. In online distance learning, not only does the instruction occur via a
computer system, usually over the Internet, but other educational processes occur via the computer as well.
These educational processes are student services, training, and support. The transition to online distance
learning, primarily driven by social change, is creating a paradigm shift in the way colleges are viewing
teaching and learning (Rogers, 2000). Administrators, faculty, staff, and students realize that in order to
successfully implement ODL, their colleges will need to reassess their programs (levy,retrieved,Apr,2013).
Unit #5 of the weekly foreign words series for senior English. These words are a collection of foreign words that are used in our English language today. I am using the word list from "The Literature Teachers Book of Lists".
A Short Report on Status of Leprosy in India by Rahul Shukla in Advances in Complementary & Alternative Medicine
Hansen’s disease, known as leprosy in colloquial language has been able to maintain its prevalence in the Indian subcontinent due to the haggard socio-economic status, lack of awareness and multiple other predisposing factors. Leprosy has been found to suppress the immune system thereby accentuating the chance of secondary infections. Contrary to the long held prevalent notion that the disease is not very contagious but shows long term effects that may lead to permanent limb and nerve disfigurement. The chronic effects of the ailment also include loss of visual acuity along with deformed limbs. Despite the prevalence and emergence of substantial number of new cases of leprosy each year in most of the developed and developing nations, the disease has still not been identified as a major health problem. The major hurdle in tackling the disease is also stemmed from the under reporting of the ailment caused by the excommunication of the afflicted individuals. India accounts for a large chunk of the global burden of leprosy, contributing almost 3/5th of the newly documented cases per annum. Reemergence of leprosy has been evidenced due to development of resistance in the causative bacterial strain. Yet much has not been accomplished in developing therapeutic regimen to curb the rampage of this insidious enemy. The aim of this short communication aims at portraying the true scenario of leprosy and there by attract the attention of policy makers and implementers to take radical actions to eradicate the menace to public health.
34.Vohra P, Rahman MSU, Subhada B, Tiwari RVC, Nabeel Althaf MS, Gahlawat M. Oral manifestation in leprosy: A cross-sectional study of 100 cases with literature review. J Family Med Prim Care. 2019 Nov;8(11):3689-3694. doi: 10.4103/jfmpc.jfmpc_766_19. eCollection 2019 Nov. PubMed PMID: 31803674; PubMed Central PMCID: PMC6881956.
Vohra P, Rahman MS, Subhada B, Tiwari RV, Nabeel Althaf MS, Gahlawat M. Oral manifestation in leprosy: A cross-sectional study of 100 cases with literature review. J Family Med Prim Care 2019;8:3689-94
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IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
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IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
The prostate is an exocrine gland of the male mammalian reproductive system
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A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
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"A Study of Clinical Profile of Leprosy in Post Leprosy Elimination Era"
1. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 14, Issue 11 Ver. VIII (Nov. 2015), PP 04-12
www.iosrjournals.org
DOI: 10.9790/0853-141180412 www.iosrjournals.org 4 | Page
"A Study of Clinical Profile of Leprosy in Post Leprosy
Elimination Era"
Dr.G.Swarnakumari1
, Dr.T.V.Narasimha Rao2
, Dr.S.Ngeswaramma3
,
Dr.T.Vani4
, Dr Rammohan Ch5
, Dr.Ramadasu Naik Neenavathu6
.
1,2,3,4
Department of Dermatology, Venereology and Leprosy, Guntur Medical College, Andhra Pradesh, India
Abstract:
Background: Leprosy is a chronic granulomatous infectious disease caused by Mycobacterium leprae, primarily
affecting the skin and peripheral nerves. A long course of the disease coupled with stigmata attached to it often
create grave socio-economic problems. In December, 2005, India announced elimination of leprosy as public
health problem at national level under the National Leprosy Eradication Programme. But still more number of
new cases are still being registered in India . Increased number of new cases were deteced during the year 2011 –
2012 as compared to 2010 – 2011.So a study was conducted on the clinical profile of newly diagnosed leprosy
cases and patients already diagnosed and on treatment,in this post leprosy elimination era.
Materials and methods: The study group was drawn from patients attending the outpatient and inpatient
departments of Dermatology, Venereology and Leprosy (DVL) at Government General Hospital, Guntur ,Andhra
Pradesh for a period of one and half year, from January 2013 to June 2014.A total of 194 leprosy cases were
enrolled for the study.
Study design: Prospective observational study.
Results: In the present study the youngest patient was 3 yrs old and the oldest was 85 yrs. The maximum number of
patients belonged to the 20-29 years age group. The male to female ratio was 2.3:1.Out of 194 cases,102 were
diagnosed as Borderline tuberculoid leprosy,30 as pure neuritic leprosy,23 as lepromatous leprosy,13 boderline
lepromatous leprosy, 3 as mid bordeline leprosy ,.3 as indeterminate leprosy and 2 as tuberculoid leprosy.10
patients presented with type 2 lepra reaction and 8 presented with type 1 lepra reaction. Majority of the patients
belonged to low income group. Deformities were mainly observed in borderline tuberculoid and lepromatous
leprosy patients.
Conclusion Most new cases detected are may be hidden prevalent cases.But this may also suggests active
infection in the community and warrants resurgence of leprosy. This is probably due to fixed duration therapy of
one year to multibacillary cases and discontinuation of surveilllance activities .we should not be complacent at
this stage because it may become a serious health problem again. By early detection and increasing the duration
of therapy and increasing community awareness utilising Informatoin, Education and Communication (IEC) at
all levels, we can hope to achieve the dream of leprosy free India.
Key words: Leprosy, post leprosy elimination era, new cases , community awareness.
I. Introduction
Leprosy(Hansen’s disease; Hanseniasis) is a chronic disease of man (infectious in some cases) caused by
Mycobacterium leprae (M.leprae). It primarily affects the peripheral nervous system and secondarily involves
skin and certain other tissues , notably the eye, the mucosa of the upper respiratory tract, muscle ,bone and
testes.[1,2]
Leprosy is considered important mainly because of its potential to cause permanent and progressive
physical deformities with serious social and economic consequences. Leprosy occurs in all ages ranging from
early infancy to very old age. Male to female ratio is 2:1 There are numerous social factors which favour the
spread of the disease in the community such as poverty and poverty related circumstances (eg: overcrowding, poor
housing ,lack of education and lack of personal hygien.).
Leprosy is regarded as a special disease because 1. Slow, generation time of the bacillus( two weeks).
This results in long incubation period (average 5-7 yrs),a very slow development of pathology, a slow and
insidious clinical evolution and unclear epidemiological pattern .2. The bacillus has never been conclusively
grown in artificial medium and consequently the bacteriology of leprosy was greatly delayed until 1960 when
limited growth in mice was achieved. 3. This is the only bacillary disease with a predilection for nerve tissue. 4
.Man alone gets leprosy ,and is the reservoir of infection , although naturally infected armadillos have been found
in the Southern USA and primates in Africa. 5. Leprosy is the best example of a disease which has a spectrum
from complete absence of resistance by the host to effective immunity, which is often accompanied by extreme
and destructive hypersensitivity. In lepromatous leprosy bacillary invasion is such that the number of bacilli in
the dermis can reach 10 9
per gram tissue.In tuberculoid leprosy on the other hand the cell mediated response to the
2. "A Study of Clinical Profile of Leprosy in Post Leprosy Elimination Era"
DOI: 10.9790/0853-141180412 www.iosrjournals.org 5 | Page
presence of bacilli is so violent that it continues in the presence of a bacillary population which is too small to be
detectable .6. Leprosy deforms and disables but seldom kills, so that those it has crippled live on ,getting steadily
worse ,their deformities visible to all the community.[3.2].
M.leprae has a preference for temperature less than 37 0
C for its optimal growth.so it predominantly involves
skin, nasal mucosa and peripheral nerves where the temparature is lower than core body temparature.
Transmission: Untreated multibacillary cases are the most important source of infection compared to pauci
bacillary cases
Classification: With the WHO guidelines for leprosy control programmes, the classification assumes utmost
importance to decide upon the line of treatment. A single classification to meet everyone's expectation though
desirable may be very difficult to arrive at.
The well accepted classifications include new IAL (Indian Association of Leprologists), Ridley -Jopling,
and WHO classification for leprosy control.
The new IAL classification (1981) ;1. Lepromatous (L), 2. Tuberculoid (T), 3. polyneuritic (P), 4. Bordeline (B),
5. Indeterminate (I)
Ridley – Jopling classification : It is essentially a five group classification with two polar
forms-tuberculoid (TT) and lepromatous (LL) are the two extremes which are more or less immunologically
stable. Between the two polar forms lies a big immunologically unstable borderline group which has subdivided
into three categories –borderline tuberculoid (BT) ,mid borderline or borderline borderline (BB) and borderline
lepromatous (BL).
The WHO classification (1998) for leprosy control programmes:
The patients are categorised into 1. Paucibacillary single lesion leprosy ( SLPB) 2.Paucibacillary leprosy
(2-5 skin lesions) 3. Multibacillary leprosy - six or more skin lesions and also smear positive lesions.
Presently in India the number of nerves involved is also taken into consideration while categorising the
patients into paucibacillary and multibacillary types as per the criterion laid down under the National Leprosy
Eradication programme( NLEP) of government of India.
Classification under NLEP, India (2009)
Sr.No. Characteristics PB MB
1. skin lesions 1-5 lesions 6 and above
2. Peripheral nerve involvement No nerve /only one nerve with or
without 1-5 lesions
More than one nerve irrespective of
the number of skin lesions
3. Skin smears Negative at all sites Positive at any site
Note: if skin smear is positive, irrespective of number of skin and nerve lesions ,the disease is classified
as MB leprosy but if skin smear is negative it is classified on the basis of the number of skin and nerve lesions.
Presently, the WHO classification for treatment purposes and Ridley-Jopling classification for academic and
research work is being followed satisfactorily.
Rare variants of leprosy : Few unusual forms or expressions of leprosy do not fit into the standard classification
of disease.These are 1.Lucio leprosy 2.pure neuritic leprosy 3.Histoid leprosy 4.Lazarine leprosy.
Reactions in leprosy: Reactions are acute inflammatory episodes which occur during the course of leprosy.
Reactions are principally two types:
1.Type- 1 reaction, also referred to as upgrading (reversal reaction) 2. Type- II reaction or erythema nodosum
leprosum (ENL) reaction.
Unattended neuritis in leprosy can result in a wide range of nerve function impairment (NFI) especially
of hands, feet and eyes, ultimately leading to anaesthesia, muscle weakness ,deformities, neuropathic ulcers and
resulting disabilities.
WHO Study group, in 1981 recommended multi drug therapy (MDT) regimen for 24 months or till smear
negativity in MB leprosy and for six months in PB leprosy.
Multibacillary leprosy : recommended regimen for adults is:
Rifampicin(600 mg) once a month supervised ,Dapsone (100mg ) daily self-administered and
Clofazamine (300mg) once a month supervised and 50 mg daily self-administered .Duration is 24 months.
Paucibacillary leprosy recommended regimen for adults is:
Rifampicin(600mg) once a month supervised and Dapsone (100mg) daily self-administered.Duration is 6 months.
Children should receive proportionately reduced doses of the above drugs.
In 1997, the WHO Expert Commitee on leprosy and NLEP recommended Fixed Duration Treatment
(FDT) – 12 months for MB leprosy and 6 months for PB leprosy in the programme. This was not accepted by all
clinicians. Their fear is based on the report from Bamako , Mali and JALMA, Agra who reportd high relapse rates
in patients with Biological index more than 4.0 (10-100 bacilli in an average field) following FDT.
This fear is still haunting many clinicians (and even policy makers) who do not favor stopping MDT at
the end of 12 months.
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Rationale for shortening the duration of MDT to 12 months is:to facilitate better treatment compliance
without significantly compromising the efficacy, and that rifampicin kills over 99.9%of the viable organisms with
three monthly doses .The major role of the dapsone – clofazamine component in MDT is to ensure the elimination
of rifampicin resistant mutants from the bacterial population.(3)
Disease prevalence is defined as the number of patients diagnosed with leprosy and registered for the
treatment over the course of a year.
Elimination of leprosy is prevalence rate of less than one case per 10,000 population , where leprosy is
considered to cease as public health problem .
In India , efforts to control leprosy began in 1954 when the National Leprosy control programme (NLEP)
was launched. MDT for leprosy was introduced in India from 1983 onwards. India reached elimination target of
leprosy by the end of year 2005.
In India , the National prevalence rate which stood at estimated 57.6 per 10,000 population in 1981; has
come down to 0.72 per 10,000 by March 2009.The disease ,though eliminated it is not eradicated.
Aims and Objectives of the study : 1. To identify new leprosy cases amongst the patients attending the DVL
department 2 .to identify the leprosy cases who are on the treatment during the study 3. to study the clinical profile
of the patients identified.
II. Materials and Methods
The study group was drawn from the outpatient and inpatient departments of DVL at Government
General Hospital , Guntur ,Andhra Pradesh, for a period of one and half year from January 2013 to June 2014 .A
total of 194 leprosy cases were enrolled for the study .
Study design : prospective, observational study.
Methodology: After obtaining clearance and approval from the institutional ethical committee, 194 cases were
included for the study. Informed and written consent was taken from patients and the clinical data was recorded
.Detailed history taking and complete clinical examination was done. Clinical photographs were taken at the same
time sitting. A detailed history was taken with particular reference to the duration, initial site of appearance of
lesion, extension of lesions , symptoms, history of underlying systemic conditions like diabetes mellitus ,
hypertension , tuberculosis was obtained. All patients were investigated with routine haematological and
biochemical investgations. Skin biopsy, slit skin smear examination for acid fast bacill and HIV screening were
performed as and when needed. The collected data was analysed.
III. Results
Table – 1: Age Distribution
TT BT BB BL LL PN IL Type1 Type
2
Total
Lessthan10 - 1 - - - - 2 - - 3 (1.54%)
10 – 19 - 14 - 2 1 2 1 2 1 23 (11.85%)
20 – 29 1 31 2 3 3 8 - - 2 50 (25.77%)
30 – 39 - 18 - - 8 3 - 1 1 31 (15.97)
40 – 49 1 19 - 3 6 7 - 1 3 40 (20.61%)
50 – 59 - 7 - 4 2 6 - 2 2 23 (11.85%)
60 – 69 - 7 1 1 2 2 - 2 1 16 (8.24%)
>70 - 5 - - 1 2 - - - 8 (4.12%)
2 102 3 13 23 30 3 8 10 194
In the present study, the youngest patient was 3 years old and the oldest was 85 years. The maximum
number of patients in this study belonged to the 20-29 years age group whereas the least number of patients (3)
belonged to the less than 10 years age group.
Sex distribution according to type of disease
The male patients comprised 136 (70.1%) and female patients were 58 (29.89%) . The male to female
ratio was 2.3 : 1
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Table – 2: Sex Distribution According To Type Of Disease
Males Females Total
Types No % No % No %
TT 1 0.73 1 1.72 02 1.03
BT 64 47.05 38 65.51 102 52.57
BB 3 2.20 - - 03 1.54
BL 8 5.88 5 8.62 13 6.70
LL 21 15.44 2 3.34 23 11.85
PN 22 16.17 8 13.79 30 15.46
IL 2 1.47 1 1.72 03 1.54
Type1 6 4.41 2 3.34 08 4.12
Type2 8 5.88 2 3.34 10 5.15
Total 136 58 194
Clinical diagnosis
Table – 3 : Clinical Diagnosis
Type Total Percentage
TT 2 1.03
BT 102 52.57
BB 3 1.54
BL 13 6.70
LL 23 11.85
PN 30 15.46
IL 3 1.54
Type1 8 4.12
Type2 10 5.15
Out of 194 cases 102 (52.57%) patients were diagnosed as having borderline tuberculoid leprosy(BT) ,
followed by 30 patients (15.46%) as poly neuritic leprosy (PN ), 23 ( 11.85%) as lepromatous leprosy (LL) , 13
(6.7 %) as borderline leprosy (BL ) , 10 (5.15 %) as type 2 lepra reaction , 8 (4.12) as type I lepra reaction ,3
(1.54%) as indeterminate leprosy (IL ), 3 (1.54%) as borderline borderline leprosy (BL ) and 2 (1.03 %) as
tuberculoid leprosy (TT).
Socioeconomic status
Table – 4 : Socioeconomic Status
Type Low Income Group Middle Income Group Total
TT 2 (1.28%) - 2 (1.03%)
BT 89 (57.05%) 13 (34.21%) 102 (68.04%)
BB 2 (1.28%) 1 (2.63%) 3 (1.54%)
BL 10 (6.41%) 3 (7.89%) 13 (6.70%)
LL 16 (10.25%) 7 (18.42%) 23 (11.85%)
PN 22 (14.10%) 8 (21.05%) 30 (15.46%)
IL 2 (1.28%) 1 (2.63%) 3 (1.54%)
Type1 6 (3.84%) 2 (5.26%) 8 (4.12%)
Type2 7 (4.48%) 3 (7.89%) 10 (5.15%)
Total 156 38 194
In this study 156 (80.41%) patients were from low income group whereas 38( 19.58%) patients were
from middle income group. There were no patients from high income group.
Occupation
Table – 5 : Occupation
TT BT BB BL LL PN IL Type1 Type2 Total
Agriculture 1 9 1 1 5 - - 2 19 (9.8%)
Auto driver - 4 - 1 2 3 - - 1 11 (5.7%)
Barber - - - - 1 - - - 1 (0.5%)
Business - 1 - - 1 - - - - 2 (1.03%)
Cook - - - 1 - - - - 1 (0.5%)
Coolie 1 38 1 9 11 14 - 6 5 85 (43.8%)
Farmer - 3 - - 1 1 - - - 5 (2.6%)
Housewife - 14 - 1 2 - - - 17 (8.8%)
Labour - 2 - - 1 1 - - 1 5 (2.6%)
Mechanic - 2 - - 1 - - - - 3 (1.5%)
No work - 10 - - 3 2 - - - 15 (7.7%)
Nursing staff - 1 - - 1 - - - 2 (1.03%)
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Painter - 1 - - 1 - - - - 2 (1.03%)
Pharmacist - 1 - - - - - - - 1 (O.5%)
Private job - 1 - - 1 - - 1 1 4 (2.1%)
Retired employ - 1 1 - - - - 1 - 3 (I.5%)
Student - 13 - 1 - - 3 - - 17 (8.8%)
Tailor - 1 - - - - - - - 1 (0.5%)
2 102 3 13 23 30 3 8 10 194
Maximum number of patients 85 (43.8%) were found to be coolies. The next common was agriculture
labour 19 (9.8%), house wives were 17(8.8%) and students 17(8.8%)
Table – 6 : Duration
Duration TT BT BB BL LL PN IL Type1 Ttpe
2
Total
< 6 Months - 43 3 6 13 17 3 2 9 96 (49.5%)
6-11Months 1 21 - 4 5 7 - 1 1 40 (20.6%)
1-5 Years 1 31 - 3 5 6 - 5 - 51 (26.3%)
6-10 Years - 6 - - - - - - - 06 (3.1%)
>10 Years - 1 - - - - - - - 01 (0.51%)
Maximum number of patients 96(49.5%)in this study had the duration of less than 6 months , it was between 1-5
yrs in 51(26.3%) and 6-11 months in 40(20.6%)
Table-7: Lepra Reactions
REACTION TT BT BB BL LL PN IL HISTOID TOTAL
Type 1 - 7 1 - - - - - 8 (4.12%)
Type 2 - - - - 8 - - 2 10 (5.15%)
In a total of 194 patients, 8 patients (4.12%) had type I reaction which was seen in 7 BT patients i.e.(87%)
and 1 BB patient (12%).10 patients (5.15%) had type 2 lepra reaction i.e. in 8 patients of LL (80%) and 2 patients
of Histoid leprosy (20%).
Table-8: Deformities
Deformities TT BT BB BL LL PN IL Type1 Type2 Total
No
deformities
2 83 2 10 7 18 3 5 6 136 (70.1%)
AOT - - - - 4 - - - - 04 (2.1%)
Claw hand - 5 - 1 - 4 - - - 10 (5.2%)
Fissures - 4 - 2 3 - - 1 - 10 (3.1%)
Foot drop - 2 - - 2 1 - - - 05 (2.6%)
PCH - 2 - - - 1 - - - 03 (1.5%)
Ulcer - 7 - 1 9 3 - 2 3 25 (12.9%)
Wrist drop - - 1 - - - - - - 01 (0.5%)
PCH-partial claw hand; AOT- absorption of toes.
Amongst patients of BT trophic ulcers were found in 7( 6.8%) , claw hand in 5(4.9%) and foot drop and
partial claw hand in 2 (1.94%) patients each . Amongst patients of PN 4 (14.8%) had claw hand and 3 (11.1%)
trophic ulcers . Amongst LL patients 9 (36%) had trophic ulcers,4 (16%) had absorption of toes and fissures in
3(12%) and 2(8%) had foot drop.
TABLE-9: On Treatment Cases
Type TT BT BB BL LL PN IL Type1 Type2 Total
No.of cases 1 21 0 2 4 4 0 2 3 37(19.1%)
Out of 194 patients,37 (19.1%) were on treatment during the study. The minimum duration is 1 month
and maximum duration was 8 months. All the patients were on MDT- MB treatment.
Leprosy is a spectral disease in which the clinical and pathological features reflect the cell mediated
immunity of the host. The WHO classification of dividing leprosy into PB (<5 lesions) and MB (>5 lesions) is
recommended for routine use and either Indian or Ridley –Jopling classification for research workers. Pure
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neuritic leprosy has been recognised as a separate group in Indian classification.
II. Discussion
1.Age distribution: In the present study , the youngest was 3 yrs old and the oldest was 85 yrs. 3 children were
below 10 yrs which suggests high infectivity status in the community. Positive family / contact history in
childhood leprosy was seen in almost half of the cases. All 3 patients with indeterminate leprosy had positive
family history. It indicates that contacts in the family play a significant role in development of the disease.
In the present study majority patients 81 (41.75%) belonged to the age group of 20-39 yrs i.e.
reproductive active age group in both sexes.
Santaram and Porichha[4]
found the disease to be more common in the age group of 21-40 yrs. Similarly
Samuel et al[5]
, found the disease to be more common in the age group of 21-40 yrs(48%). Singh et al,[6]
found the
disease in 53 % of patients belonging to age group of 21-40 yrs.
Thus the age incidence observed in the present study correlates well with that of the other studies. The
disease is more common in this age group indicates vulnerability because of greater mobility and increased
opportunity for contact in big population.
2. Sex distribution: In the present study 70.1% of patients were males and 29.9% were female patients.
Santaram and Porichha[4]
found the disease in 80% of males and 20% of females. Singh et al[6]
found the
disease in 69% of males. The results of the present study are close to the above mentioned studies with regard to
the sex. This can be explained as a fact that males go for outdoor work more compared to females hence have the
higher chance of getting the infection .As a result of their life style males in general expose themselves to greater
risk of infection. Differing clothing habits especially in cases of women who cover their bodies more than men
have reduced opportunities for skin contact. Male preponderance may also be due to difference in health seeking
behaviour of men and females are slow to self report.
3. Clinical diagnosis: out of 194 cases ,2 (1.03%) were diagnosed as TT,102 (52.57%) as BT,3 (1.54%) as BB,13
(6.70%) as BL ,23 (11.85%) as LL,30 (15.46%) as PN , 3 (1.54%) as IL, 8 (4.12%) as Type 1 lepra reaction and 10
(5.15%) as type -2 lepra reaction.
Jindal et al,[8]
found LL in 33% of patients BL in 23 % of patients ,TT in 5.5% of patients BB 4% ,IL and
pure neural 3% each of patients.
Arora et al[9]
found BB and BL in 45% of patients ,BT 27.5% ,LL in 15.5%, pure neural in 9 % and 1.3%
each in IL and TT patients.
Thus the clinical types of leprosy observed varies from study to study and place to place.
Borderline leprosy lesions are more apparent and this may be a reason for more patients self reporting
with borderline forms of leprosy. Increase in the proportion of multi bacillary cases is important as they represent
major source of infection.
In the present study,15.46% of the patients presented with neuritic leprosy.
Follow-up of the pure neuritic leprosy shows the development of skin lesions over 3-5 yrs .This suggests that
neuritic symptoms probably are the earliest symptoms of leprosy before the development of skin lesions and that
is why, patients of pure neuritic leprosy must be followed up for long time.
Socio-economic status : In the present study 80% of the patients were from low income group and 20% of
patients belonged to middle income group.
Similar observations were made by Chhabriya et al[10]
wherein the majority of patients belonged to low
income group.
Sing et al,[6]
found the disease in 57% of patients belonging to poor socio-economic status followed by
21.6 % in lower – middle socio-economic status people.
Highest incidence among the socio-economically down trodden persons who lived in poor conditions
resulting in overcrowding, poor sanitation and poor nutrition, illiteracy and lack of personal hygiene are important
factors in acquisition of the disease in case of leprosy. Domestic overcrowding provides ideal conditions for
infection whether by droplets or by skin to skin contact and under nourishment reduces cell mediated immunity.
Another possible reason for higher incidence among illiterates is the lack of knowledge regarding the
regular treatment and also the habit of attending the leprosy clinic in the late stage of the disease as many of these
people attribute this to diseases like Pityriasis( Tinea) versicolor. If people come early for treatment the incidence
of complications will be low.
Occupation: In the present study the disease was most common among the coolies(43.81%). Ankad et al,[11]
found higher incidence among manual labourers and agriculture workers. In a study by Choudhuri et al,[12]
90% of
patients were agriculture related workers.
This is again as observed earlier due to the factors like low economic status which is associated with
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illiteracy, overcrowding, poor personal hygiene and malnutrition which are common among people persuing the
manual labour work. Another possible cause is lack of adherence to therapy because they are ignorant about the
consequences of the disease.
Duration: In the present study duration of the illness by the time of presentation was less than 6 months in 49.5 %,
6-11 months in 20.6% of patients and 1-5 yrs in 26.3% patients.
Wim et al[13]
found the duration of disease to be upto 6 months in 30%,7-12 months in 32%,13-24 months in 17%,
25- 36 months in 9.3 %,37-60 months in 6.3% and more than 60 months in 5.4%. Majority of people are coming
relatively earlier i.e. within 2yrs of onset of disease but this log period must be further reduced to prevent disease
complications. Leprosy is still considered as a contagious and unclean disease, therefore patients particularly
females tend to hide their disease and delay their treatment at the time when they could have been easily cured.
The duration of disease was less than 6 months in majority of patients with BT leprosy, this is because of early
onset of symptoms in these patients. They present to hospital earlier than those in other spectrum of disease.
Lepra reactions : In the present study 8 patients out of 194 had (4.2%) type 1 lepra reaction, out which 7 were BT
patients(87%) and 1 was BB patient and 10 patients(5.2%) had type 2 lepra reaction, out of which 8 were LL
patients and 2 patients were Histoid.
Arora et al[59]
found the reaction in 34 % of their patients and type 1 reaction was significantly more
compared to type 2 lepra reaction. In the present study type 2 lepra reaction was more commonly seen when
compared to type 1 lepra reaction.
The occurrence of type 1 reaction during the first year of treatment and that of 2 after 2 years is an
established fact. With regard to the recurrences single episode was more common in type 1 reaction and multiple
episodes in type 2 reaction.
It is very essential to recognise the reactional leprosy irrespective of the type of reaction. This is because
the patients with type 1 reaction are more prone for deformities which are responsible for the stigmata attached to
leprosy, where as the patients with type 2 reaction are more for systemic complications like nerve pain, bone pain,
pain in joints, iritis, episcleritis, painful dactylitis. epididymo orchitis, acute glomerulo nephritis etc. Which make
the persons unproductive adding to socio-economic liability.
Education of the patients regarding the disease especially regarding the reactions goes a long way in
containing the social problems .As the reactions are more common after initiating therapy, patients should be well
counselled about the possibility of occurrence of reactions and they should not defer from treatment.
Deformities: In the present study 58 (29.9%) patients showed deformities in the form of claw hand, foot drop,
trophic ulcers and resorption of digits, which suggests delay in diagnosis, treatment and lack of disease awareness
in the patients.
Nagabhushanam[7]
found claw hand deformity in 17.3% of patients and more of the patients revealed wrist drop,
out of 410 patients.Though MDT has made a sea change in profile of the disease,disabilities continue to be a major
problem.Leprosy has been a feared and stigmatised disease mainly because of the deformities associated with it.
Cases on treatment during study: In the present study out of 194 patients, 37 (19.1%) patients were on treatment
during study. Maximum number patients 21 (10.8%) were seen in BT group followed by 4 (2.6%) in LL and PN
each and 3(1.54%) in type 2 reaction.
There was an increase in the new cases registered in 2012 as compared to 2011 in India (5.9%).This
could be because of hidden prevalent cases, improved case detection activities and improved programme
coverage.
However new leprosy cases may suggests active infection in the community and warrants resurgence of
leprosy. This is probably due to fixed duration of therapy for one year to multibacillary leprosy which may be
insufficient and discontinuation of surveillance activities. As leprosy has got long incubation period and persistent
course , resurgence of leprosy may become a serious health problem again.
The contribution of dermatologists in the success of leprosy elimination is well recognised.
Dermatologists play an indispensable role in the current setting by :1.Acting as a ‘’safety-net’’ for patients
‘’missed’’ by other health services by 2. Managing the complications and by 3 training health service staff
about case detection and treatment for more efficient management at peripheral level.
In addition, issues relating to stigma ,discrimination and rehabilitation need to be tackled in a more
integrated and inclusive manner to realize the dream of leprosy - free India. Good housing and living conditions
and good nourishment decrease the spread of leprosy.
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III. Limitations and conclusion
Patients included in the present study were only those who attended the out patient and inpatient
departments of DVL of Government General Hospital, Guntur. Hence this study gives limited information about
the epidemiology of the disease.
The duration of study was only one and half year. So further studies are required to know the disease
status better which helps in planning for preventive measures, early diagnosis and management.
Even now ,around a quarter of a million new cases are recorded each year all over the world, ranking
leprosy as the 11th
highest cause of mortality and 12th
highest cause of morbidity from neglected cases (15).
Perhaps
we are failing to understand some important aspects of the disease’s natural history.Prospect of elimination has
discouraged the research in the field There is disappointingly very littlle progress in the development of an
effective vaccine for leprosy.[3]
Till such understanding is achieved, some high endemic pockets of leprosy may continue to persist in
India. In such a scenario the main principles of leprosy control are 1. increasing the duration of treatment in
multibacillary cases especially smear positive, BL and LL cases thereby decreasing the spread 2. timely detection
of new cases and prompt treatment to prevent deformities in the affected and the spread of disease in community
through increasing the surveillance activities.3. Keeping families of patients under surveillance 4.Improving
socio-economic conditions 5.Health education and publicity about leprosy, with emphasis on early presentation
for diagnosis and the likelihood of cure by multiple drug therapy. Self presentation for diagnosis should be greatly
encouraged .6.Increasing community awareness utilising Information, Education, and Communication (IEC)
activities at all levels and in all states with more emphasis on endemic states should be launched. 7.The message
should be in local language to be more effect.
PHOTOGRAPHs
BBorderline Tuberculoid Leprosy great auricular nerve enlargement
BBB
Mid Borderline Leprosy (inverted saucer shape appearance) Lepromatous leprosy with Ear lobe infiltration
Lepromatous Leprosy with Erythema necroticans Histoid Leprosy
9. "A Study of Clinical Profile of Leprosy in Post Leprosy Elimination Era"
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LL with Leonine facies-appearance Claw Hand
Trophic Ulcer
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[2]. Anthony D.M.Bryceson.Leprosy,3rd
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[3]. Hemanth kumar Kar.IAL Text book of leprosy2010,.p28-30,145-150,357
[4]. SantaramV, PorichhaD.Reaction cases treated at the regional leprosy training and research institute. Indian J Lepr
2004;76(4):310-320
[5]. Samuel et al. MDT of leprosy-practical application in Nepal. Lepr Rev 1984;55:265-272
[6]. Singh et al. Participation level of the leprosy patients in society.Indian J Lepr 2009;81:181-187
[7]. Nagabhushanam P.Gross deformities in leprosy. Indian J Dermat & Vener 1967;33:70-72
[8]. Jindal ey al. Clinico-epidemiological trends of leprosy in Himachal Pradesh.Indian J Lepr 2009;81:173-179
[9]. Arora et al. Changing profile of disease in leprosy patients diagnosed in a tertiary care centre during years 1995-2000 . Indian J Lepr
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[10]. Chhabriya BD, et al.Bone changes in leprosy: A study of 50 cases.Indian J Lepr 1985;57(3):632-639.
[11]. Ankad et al. Clinical and radiological changes in hands and feet in leprosy.2005.
[12]. Choudhuri H, et al .Bone changes in leprosy patients with disabilities/deformities (A clinico –radiological correlation ) Indian J Lepr
1999;71(2):203-205.
[13]. Wim et al. The INFIR Cohort study: investigating prediction, detection. detection and pathogenesis of neuropathy and reaction in
leprosy .Method and baseline results of a cohort of multibacillary leprosy patients in North India .Lepr Rev 2005;76:14-34.
[14]. Darmendra,Job CK.Histopathology of skin lesions in leprosy.1st
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[15]. IADVL Textbook of Dermatology 4th
edition.2008,vol 3 ,p 3213