IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
—Fungal organisms are ubiquitous. A common location for these organisms to enter the human body is through the external acoustic canal, oral cavity, and pharynx and sino-nasal cavity. A study was conducted with clinical and mycological analysis of various fungal infections in ENT. Patients suspected for having fungal infections attending at Department of ENT were interrogated and analysed. Swabs collected from these cases were sent for direct microscopy by KOH mounts for fungal examination and fungal culture. Microbiological confirmed 100 cases were finally included in the study Histopathological examination of nasal mass and polyposis was also done. It was observed in this present study otomycosis was most common and accounted for 84% of the total cases followed by candidiasis in oral cavity and pharynx in 9%, allergic fungal rhinosinusitis in 4% and rhinosporidiosis in 3%. Aspergillus niger was that most common fungus isolated in 61% cases, followed by Candida albicans in 24% cases, Aspergillus flavus in 9% cases, Aspergillus fumigatus and Rhinosporodium seeberi in 3% cases each. All the cases of fungal infection of oral cavity and oropharynx were due to Candida albicans.
Monkeypox is a rare zoonosis caused by monkeypox virus. This disease is similar to smallpox disease but with lesser severity. This disease is common among Africans. It can be prevented by avoiding contact with contaminated animal and human fluids as well as respiratory droplets. It require a multidisciplinary approach to achieve cure and prevention.
GEMC - Parasitic Infections - for NursesOpen.Michigan
This is a lecture by Katherine A Perry from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
Bovine herpesvirus 1 (BHV-1) is associated with several diseases in cattle: infectious bovine rhinotracheitis (IBR), infectious pustular vulvovaginitis (IPV), balanoposthitis, conjunctivitis, abortion, encephalomyelitis, and mastitis.
—Fungal organisms are ubiquitous. A common location for these organisms to enter the human body is through the external acoustic canal, oral cavity, and pharynx and sino-nasal cavity. A study was conducted with clinical and mycological analysis of various fungal infections in ENT. Patients suspected for having fungal infections attending at Department of ENT were interrogated and analysed. Swabs collected from these cases were sent for direct microscopy by KOH mounts for fungal examination and fungal culture. Microbiological confirmed 100 cases were finally included in the study Histopathological examination of nasal mass and polyposis was also done. It was observed in this present study otomycosis was most common and accounted for 84% of the total cases followed by candidiasis in oral cavity and pharynx in 9%, allergic fungal rhinosinusitis in 4% and rhinosporidiosis in 3%. Aspergillus niger was that most common fungus isolated in 61% cases, followed by Candida albicans in 24% cases, Aspergillus flavus in 9% cases, Aspergillus fumigatus and Rhinosporodium seeberi in 3% cases each. All the cases of fungal infection of oral cavity and oropharynx were due to Candida albicans.
Monkeypox is a rare zoonosis caused by monkeypox virus. This disease is similar to smallpox disease but with lesser severity. This disease is common among Africans. It can be prevented by avoiding contact with contaminated animal and human fluids as well as respiratory droplets. It require a multidisciplinary approach to achieve cure and prevention.
GEMC - Parasitic Infections - for NursesOpen.Michigan
This is a lecture by Katherine A Perry from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
Bovine herpesvirus 1 (BHV-1) is associated with several diseases in cattle: infectious bovine rhinotracheitis (IBR), infectious pustular vulvovaginitis (IPV), balanoposthitis, conjunctivitis, abortion, encephalomyelitis, and mastitis.
Monkeypox is derived from the genus Orthopoxvirus from the family Poxividae. This
genus has two kinds of viruses: smallpox and monkeypox virus. Monkeypox is a
zoonotic disease (spread from animal to human or vice versa) and was initially
diagnosed with pox-like symptoms on colonies of monkeys kept for research in 1958,
hence the name monkeypox. At the time of the elimination of smallpox in 1970,
monkeypox in humans was first identified in the Democratic Republic of Congo and
later in Central and Western African countries.1,2 In 2019, a newer vaccinia vaccine
was approved to prevent the disease. Furthermore, investigations are still carried out
on the same.
Animal-to-human (zoonotic) transmission can occur from direct contact with
infected animals' blood, bodily fluids, or cutaneous or mucosal lesions. In Africa,
evidence of monkeypox virus infection has been found in many animals, including
rope squirrels, tree squirrels, Gambian pouched rats, dormice, different species of
monkeys, and others. It was also found that eating improperly/half-cooked meat is
also a cause. The disease spread outside Africa by infected travellers and imported
infected animals. In 2018-2019, cases of monkeypox were confirmed in travellers
from Nigeria, Singapore, the United Kingdom, and Israel. Human-to-human
transmission can result from close contact with respiratory secretions and lesions of
the skin.3
Risk groups include people with severe illnesses who require hospitalization or an
immune-compromised person (HIV, leukaemia, etc); patients with comorbidities, a
pediatric population less than eight years old, and pregnant or breastfeeding women.2
The incubation period is generally 6-13 days, but it can range from 5-21 days. The
disease progression has two phases: The invasive phase (0-5 days), characterized by
headache, fever, back pain, myalgia, fatigue and lymphadenopathy. The rash
appearing phase (1-3 days) begins after the onset of the first phase and is
characterized by the appearance of rashes on the face and then spreads up to the
trunk and limbs of the body. Rashes evolve from macules (flat base lesions) to papules
(firm lesions), then vesicles (clear fluid- filled lesions), and finally postulates
(yellowish fluid-filled lesions) and crusts. It affects the face (in 95% of cases), palms
of the hands, and soles of the feet (in 75% of cases). Also affected were oral mucous
membranes (in 70% of cases), genitalia (30%), conjunctivae (20%), as well as cornea.
Complications of monkeypox include pneumonitis, encephalitis, sight-threatening
keratitis, and secondary bacterial infections.3,4
"A Study of Clinical Profile of Leprosy in Post Leprosy Elimination Era"iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Peste des-ruminants-is-a-rinderpest.doc pdfGudyne Wafubwa
Peste des petits ruminant virus (PPRV) is a disease mostly affecting goats and sheep. Since its first discovery, it has caused massive economic loss to most small pastoralists in Africa and other developing countries. It is the integral role of all stakeholders to join hands so as to eradicate the disease.
YAW ERADICATION PROGRAM
introduction,meaning,description about yaw, casuative agent,transmission,clinical symptom,differential dianosis,diagnosis method,treatment, preventive measure global review, national eradication program for eradication
by DR.Anjalatchi eras college of nursing ,lucknow
A lecture by Dr. Naya Hassan about Monkeybox; which is a viral zoonotic infection that results in a rash similar to smallpox and started to spread around the world since May 2022.
An Examination of Effectuation Dimension as Financing Practice of Small and M...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Does Goods and Services Tax (GST) Leads to Indian Economic Development?iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Childhood Factors that influence success in later lifeiosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Emotional Intelligence and Work Performance Relationship: A Study on Sales Pe...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Customer’s Acceptance of Internet Banking in Dubaiiosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
A Study of Employee Satisfaction relating to Job Security & Working Hours amo...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Consumer Perspectives on Brand Preference: A Choice Based Model Approachiosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Student`S Approach towards Social Network Sitesiosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Broadcast Management in Nigeria: The systems approach as an imperativeiosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
A Study on Retailer’s Perception on Soya Products with Special Reference to T...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
A Study Factors Influence on Organisation Citizenship Behaviour in Corporate ...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Consumers’ Behaviour on Sony Xperia: A Case Study on Bangladeshiosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Design of a Balanced Scorecard on Nonprofit Organizations (Study on Yayasan P...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Public Sector Reforms and Outsourcing Services in Nigeria: An Empirical Evalu...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Media Innovations and its Impact on Brand awareness & Considerationiosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Customer experience in supermarkets and hypermarkets – A comparative studyiosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Social Media and Small Businesses: A Combinational Strategic Approach under t...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Secretarial Performance and the Gender Question (A Study of Selected Tertiary...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Implementation of Quality Management principles at Zimbabwe Open University (...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Organizational Conflicts Management In Selected Organizaions In Lagos State, ...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stockrebeccabio
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stock
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Hot Selling Organic intermediates
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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Ectoparasites on genitalia in this Era - a study at tertiary care center in Telanganaand Review
1. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 14, Issue 12 Ver. I (Dec. 2015), PP 28-33
www.iosrjournals.org
DOI: 10.9790/0853-141212833 www.iosrjournals.org 28 | Page
Ectoparasites on genitalia in this Era - a study at tertiary care
center in Telanganaand Review
Dr.I. Jahnavi1,
Dr S.Suryanarayana2
, Dr S.B Kavitha1
, Dr. K. Sirsha2
,
Dr B Udayakumar1
Depts. Of DVL and Microbiology, Gandhi Medical college, and Dept. of DVL, Govt. Medical college,
Nizamabad, Telangana, INDIA.
Abstract:
Background: In the era of urbanization, civilization and HIV/AIDS a study is made to look into prevalence and
pattern of Ectoparasites(S. scabiei and P.pubis) infestation on genitalia among people attending Dermatology,
Venereology and Leprosy department of Gandhi medical College, Secunderabad, Telangana.
Objective: To determine the clinical epidemiological aspects of Ectoparasitic infestations on genitalia among
patients attending DVL department.
Methodology: All the patients attending the DVL department with complaints of itching and all the attendees of
STI clinic from October2009 to October2015 were taken up for this study. Demographic details, detailed history,
similar symptoms in family contacts taken, detailed clinical examination was done to note morphological lesions
and efforts were made to demonstrate the parasites under microscope. Data analysed.
Results: A total of 23,578 patients attended the STI clinic, out of whom 11,796 (50%) had STI. Out of STI
cases, 785 patients had scabies (6.6%) and 50 had pediculosis (0.42%).. Sarcoptes was more common among
males andpediculosis was seen only in males. Scabies was predominant in married while pediculosis was
predominant in unmarried individuals. The minimum age ofpatient was one month and maximum age was 60
years. The most common incidence of scabies and pediculosis was observed in age groups of 21-30 years.
Considering occupation, scabies and pediculosis was more prevalent among students. Both genital scabies and
P.Pubiswas higher in the urban population (60% and 84% respectively). Only genital lesions were observed in
significant number (71%). In P.Pubis along with pubic hair, 46% of patients had involvement of thighs while in
10% of cases abdomen. Almost one out of five reported cases who received single application of scabicidal
treatment showed inadequate response. Oral Ivermectin plus topical application of Permethrin or 1% GBHC
(95.5%) was superior to topical treatment with permethrin or GBHC alone. It was observed that response was
good after 2 applications of permethrin/ 1% GBHC and removal of body terminal hair in P.Pubis infestation.
Conclusion Genital scabies is still prevalent should be considered as differential diagnosis in all cases of
unexplained and persistent pruritus in the genital area. Every effort should be made to demonstrate P.pubis
parasite in all the patients with history of itching and crawling sensation especially in more hairy males and
should be treated along with partners and contacts.
Key Words: Genital scabies Scabies Nodular scabies pediculosis pubis phthyriasisSarcoptesscabiei
Introduction
The most common genital and pubic ectoparasitic infestations are scabies and pubic lice (Pediculosis
pubis) infestation. They were known since antiquity and are distributed worldwide. Patients usually present with
itching. Proper hygienic measures can lessen these diseases. Although these illnesses were not the concern of
health care systems, they can cause high morbidity and may be associated with other STI. Their incidence varies
around the world depending on type and place of living. Ectoparasitic infestation can be as sporadic, endemic or
epidemic 1
.
Pediculosis pubis: Pediculus is a blood sucking arthropod that is specific to humans. Phthirus pubis (crab
louse)involves genital area usually sexually transmitted2,3
. Itching of the pubic region is usually the principal
symptom but may also be found on thighs, abdomen, armpits, eyelashes or facial hair. Transmission occurs
through intimate sexual and non-sexual contact, from crowding of infested clothing with un-infested clothing in
locker rooms and gymnasiums, by sleeping in infested beds, or from contact with badly infested persons in a
crowd. Pubic lice tend to remain on their hosts throughout their lives unless dislodged, taken off or
controlled.Diagnosis is by identification of live lice and/or viable nits. The crab louse may be distinguished
readily from the body louse or head louse by the following: Abdomen very short and broad; segments 1-5
closely crowded, four pairs of tubercles, which stick out on each side of theabdomen.forelegs delicate, with
long slender claws; hinder legs very stout, with short and stout claws. The female lays 2-3 whitish eggs during a
24 hour period and may lay 15-50 eggs over her lifetime. The eggs hatch within 6 to 8 days. The first instar
2. Ectoparasites on genitalia in this Era - a study at tertiary care center in Telanganaand Review
DOI: 10.9790/0853-141212833 www.iosrjournals.org 29 | Page
nymphs feed for about 5 to 6days before molting. The second instar is completed within 9 to 10days and the
third instar takes about 13 to 17 days. The mature adults live for about 15 to 25 days. Lice do move about slowly
after molting. The louse inserts its mouth parts into the skin of the host, and takes blood intermittently for many
hours. Neither larvae nor adults can survive more than 24 hours without feeding. Nymphs resemble adults but
smaller and immature.
Typical Pthirus pubis infestation burden in the world appears to be approximately 2% of the (mainly) adult
population. In countries where travelers may have visited, however, infestations numbers were considerably
higher. In Nepal, for example, a control group for a study of lice in children showed pubic lice prevalence at 7%,
and 9% for pubic lice and body lice 4.
Various modalities of treatment of P.Pubis:Permethrin 1% cream orPyrethrins with piperonylbutoxide applied to
the affected area and washed off after 10 minutes,3. 1% GBHC lotion
Patients should be evaluated after 1 week if symptoms persist, retreatment with the same regimen. Patients who
do not respond to one of the recommended regimens should be treated with an alternative regimen.
Scabies: Sarcoptesscabiei, causative organism of scabies is an obligatory skin parasite. It is estimated that 300
million cases of scabies occur worldwide each year 5
, and scabies continues to be a major public health problem
in resource-poor areas. Scabies is common in children and young adults. Overcrowding which is common in
underdeveloped countries and is almost invariably associated with poverty and poor hygiene, encourages the
spread of scabies. On an average normal scabies host has only 10-12 mites but crusted scabies patient contains
hundreds to millions. The female is about 400 µm long and 300 µm wide while the male is approximately half
her size. The body has an oval, tortoise-like shape with 8 short legs that hardly project beyond the body brim.
The most important characters are the numerous ridges and scales on the back of the mite, which are not seen on
many other mange mites on mammals. Most of the mite is creamy white except for the legs and the mouthparts
that are brown. The fertilized femalesburrow into the outer layer of human skin and excavates a tunnel and lay
their eggs in these tunnels and the eggs hatch in 3-5 days. A six-legged larva is hatched, digs new tunnels and
creates small “moultingpockets” where it develops to protonymph, tritonymph, and later on to an adult mite.
The entire life cycle is completed in 10-21 days. Clinical symptoms include intensely itchy lesions that often
lead to secondary bacterial pyoderma, septicemia, and, poststreptococcal glomerulonephritis. Sarcoptes usually
involves webs of fingers, flexor aspects of wrists, anterior axillary folds, umbilicus, elbow, feet, genitalia and
other sites of body6
. The most characteristic lesion of scabies infestation is the burrow, the excavated tunnel in
which the mite lives. These burrows are usually thin, curvy, elevated tracts that measure 1–10 mm7
. Other skin
manifestations include papules, blisters, eczematous changes, and nodules8,9
. Transmission is by direct skin-to-
skin contact. A presumptive diagnosis of scabies is based on the clinical presentation of nocturnal pruritus with
skin lesions and identification of a characteristic burrow. Burrows can be best identified by mineral oil or ink
enhancement or by tetracycline fluorescence tests 7Definitive diagnosis requires microscopic identification of
mites or their eggs or feces. This is usually achieved by obtaining skin scrapings at the site of a burrow. The
burden of the disease is highest in tropical countries where scabies is endemic. Some studies reported higher
rates of disease in urban areas and an increased incidence of disease during winter months10,11,12
. Patients
receiving systemic or potent topical glucocorticoids, organ transplant recipients, mentally retarded or physically
incapacitated individuals, HIV-infected or human T-lymphotropic virus-1 infected individuals, and individuals
with various hematologic malignancies are at risk of developing crusted scabies 13
.
Various modalities of treatment of scabies:1) 5% permethrin cream applied to all areas of the body
from the neck down and washed off after 8–14 hours. This is the most common treatment for scabies. It is safe
for children as young as 1 month old and women who are pregnant. 2)1% GBHC (lindane) lotion. 3)25% benzyl
benzoate lotion. 4) 6% sulfur ointment. 5)10% Crotamiton cream/lotion. 6) Ivermectin200µg/kg orally single
dose, repeated in 2 weeks if necessary
All patients should be informed that the rash and pruritus associated with scabies may persist for up to
2 weeks after treatment completion6 14,15
.Since the mentioned diseases are considered among important parasitic
skin diseases and show the level of public health, by considering their high prevalence in our country and the
necessity of identification of region of common infections, the dominant species in the region, and the mode of
their transmission to human, we decided to report a 6-year period study of patients who attended Dermatology,
Venereology and Leprosy department of Gandhi medical College, Secunderabad, Telangana.
Objective:
To determine the clinical epidemiological aspects of Ectoparasitic infestations on genitalia among
patients attending DVL department.
Methodology:
All the patients attending the DVL department with complaints of itching and all the attendees of STI
clinic from October 2009 to October 2015 were included in this study. Demographic details, detailed history,
similar symptoms in family contacts were recorded, detailed clinical examination was done to note
3. Ectoparasites on genitalia in this Era - a study at tertiary care center in Telanganaand Review
DOI: 10.9790/0853-141212833 www.iosrjournals.org 30 | Page
morphological lesions. In the Department of Microbiology the phthirus pubis was identified under microscope
by it`s crab like appearance, stout short hinder legs with claws and blood circulation, For scabies skin scrapings
after dissolving in KOH over night was observed under microscope the mite was identified by its creamy white
Tortoise like body with it`s 4pairs of legs hardly projecting, scybala(packets of feces) and eggs .
Results:
In the present study, 11796 were diagnosed of sexually transmitted infections out of 23,578 attendees
of STI clinic from Oct 2009- Oct 2015. Of those 11796 STI patients, 785 patients had scabies (6.6%) and 50 had
pediculosis (0.42%). The patient`s minimum age was one month and maximum age was 60 years. Sarcoptes was
more common among males and pediculosis was seen only in males. The most common incidence of scabies
and pediculosis was observed in age groups of 21-30 years.Considering occupation, scabies and pediculosis was
more prevalent among students. Scabies was predominant in married while pediculosis was predominant in
unmarried individuals.
Table 1: Age and Sex distribution of ectoparasitic infestations
Age group Genital Scabies Total Pediculosis Pubis Total
Males Females Males Females
<10years 17 03 20 0 0 0
11-20 126 37 163 04 0 04
21-30 363 44 307 29 0 29
31-40 182 04 186 15 0 15
41-50 07 0 07 02 0 0
51-60 02 0 02 0 0 0
61-70 0 0 0 0 0 0
Total 697 88 785 50 0 50
TABLE 2: Age and Marital status of Genital Scabies &P.Pubis infestation
Age
Group
ToTal STI cases Genital Scabies P.pubis
Unmarried Married Unmarried Married Unmarried Married
,<10years 117 0 20 0 0 0
11-20 1213 459 24 39 04 0
21-30 3108 32122 195 212 25 04
31-40 1073 935 16 170 0 15
41-50 517 384 0 07 0 02
51-60 420 358 0 02 0 0
Totall 6448 5348 355 430 29 21
Table 3:Socio-demographic Profile of Ectoparasitic Infestations
Table 4: Occupation and Ectoparasitic infestation
Occupation G,scabie (%) P.pubis (%)
Students 198 161
Laborers 58 02
Unskilled 131 04
Skilled
worker
19 08
Business 69 08
IT Sector 22 08
House
Wife
9 0
Migrant 64 04
Total 785 50
Domiclle Genital Scabies P.pubis
Males Females Total (%) Males Females Total(%)
Urban 415 58 473(60.2%) 42 0 42(84%)
Rural 282 30 312 (39.8%) 08 0 08(16%)
Total 697 88 785 50 0 50
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DOI: 10.9790/0853-141212833 www.iosrjournals.org 31 | Page
Table 5: Genital Scabies – Morphologicallesions
Age
grou
p
Pruritis Papules Papulopustules Nodular
lesions
Eczematizatio
n
Crusted
scabies
Mal
es
Femal
es
Mal
es
Femal
es
Mal
es
Female
s
Mal
es
Femal
es
Mal
es
Femal
es
Mal
es
Femal
es
< 10 06 0 08 02 01 01 02 00 0 0 0 0
11-
20
38 18 59 15 16 04 18 0 05 0 0 0
21-
30y
186 15 128 23 27 06 23 02 02 0 01 0
31-
40
121 02 61 02 12 01 21 0 01 0 0 0
41-
50
05 0 06 0 0 0 02 0 0 0 0 0
51-
60
02 0 01 0 0 0 01 0 0 0 0 0
Total 358 35 263 42 56 12 77 02 08 0 01 0
Table 6:Sites of P.Pubis Infestation observed
Site 11-
20yrs
21-30 31-40 41-50 51-60 Total
Pubic Hair 03 12 11 01 0 25
Pubic Hair
Thighs
01 15 01 01 0 18
Pubic
hairs
thighs,
Abdomen
0 02 03 0 0 05
Eye
Brows
0 0 0 0 0 0
Eye lashes 0 0 0 0 0 0
TABLE 7: Response to treatment in Genital Scabies
Type of
Treatment
Single Application Multiple Applications
Good
Respon
se
Inadequat
e
Response
Tota
l
Good
Respons
e
Inadequat
e
Response
Tota
l
Topical
Permethrin
123 42 165 33 09 42
1%GBHC 412 113 525 87 26 113
Topical
and oral
Ivermectin
65 03 68 03 00 03
Patient-
Contacts
Treated
418 08 426 40 03 43
*27 cases lost for follow up,Partners of few patients had genital lesions clinically or symptoms of pruritus; yet
all partners were advised and administered contact treatment simultaneously.
Treatment response in P.Pubis:
Response was good after 2 applications of permethrin cream/ 1% GBHC and body terminal hair removal in
hairy patients in P.Pubis infestation
I. Discussion:
In this study, Genital scabies was diagnosed in 6.6 % of STI cases while P.pubis accounted for 0.42 %.
In Australia, Hart 16
reported that from 1988–1991 the incidence of Pthirus pubis in men attending an STD clinic
was 1.7% and in women 1.1%.Genital scabies was more common in married while P.pubis was predominant in
unmarried individuals. This study showed ectoparasitic infestation was gender-dependent; both scabies and
pediculosis are more common among males. Reports on sex differences in the incidence or prevalence of
scabies are inconsistent 13
. Some authors reported a higher incidence in men17, 18
or in women19, 20
while others
observed that scabies occurs equally in men and women 21, 22
Both Genital Scabies and P.pubis were observed to
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DOI: 10.9790/0853-141212833 www.iosrjournals.org 32 | Page
be higher in the age group of 21-30 yrs. These results are consistent with Do Ango-Padonou et al’s findings in
Benin 23
.
Both genital scabies and P.pubis were higher in the urban population (60% and 84% respectively) as
was also reported by Dr Mohamed Boushab from Mauritania. Regarding occupation, both were observed to be
common among students, Emmanuel Armand Kouotou from Cameroon also reported the same which implies
that closed communities and overcrowding are important contributory factors. In scabies the most common
clinical manifestation was observed to be pruritis followed by papules, papulopustules, nodules, eczematization.
Crusted scabies was seen in one case. Nodular scabies was significantly higher in males. Some had multiple
lesions. Only genital lesions were observed in significant number of cases (71%). This is important because
scabies is likely to be missed if only genital lesions are present. This highlights that possibility of scabies should
be kept in mind even when patient presents with only genital itching or lesions. Skin scrapings were processed
in two out of three consultations and were positive in only 67%. This diagnostic procedure is currently
considered the gold standard for the diagnosis of scabies but has low sensitivity.
Almost one out of five reported cases who received single application of scabicidal treatment showed
inadequate response. When symptoms and signs persist for >2 weeks, there were several possible explanations,
including inadequate and improper application, reinfection from family members or fomites, drug allergy,
treatment resistance or worsening rash due to cross-reactivity with antigens from other household mites.
Resistance to treatments is possible but is not very likely. The success rate of local treatments for scabies
depends on thoroughness with which the cream is applied and on the treatment of asymptomatic contact persons.
Topical application of Permethrin or 1% GBHC plus oral Ivermectin (95.5%) was superior to topical treatment
with permethrin or GBHC alone. Usha et al. 24
performed an important study addressing the relative efficacy of
topical permethrin and oral ivermectin. They found that a single topical dose of permethrin produced a clinical
cure rate for scabies (97.8%) that was superior to that produced by a single dose of ivermectin (70%). However,
2 doses of ivermectin administered at a 2-week interval were as effective as a single dose of topical permethrin.
Madan et al.25
compared ivermectin (200 µg/kg as a single dose) with 1% GBHC lotion, with >80% of patients
who were given ivermectin demonstrating a marked clinical improvement at 4 weeks of therapy, compared with
44% of patients given lindane lotion. Their study suggests that ivermectin may be a better treatment choice than
lindane, because of the good clinical response, lower toxicity, and improved adherence associated with
ivermectin.
Multiple applications were advised for those who showed inadequate response, many of such patients
were treated successfully with multiple applications. Partners of only few patients had genital lesions clinically
or symptoms of pruritus; yet all partners were advised and administered contact treatment simultaneously. In
this study all the patients of P.pubis infestation were males. It was observed to be higher in married individuals
which is consistent with the study of I.Fisher et al 26
. In P.pubis, the most common site of involvement observed
was pubic hair. It was noted that significant no.of patients(46%) had involvement of thighs while abdomen was
involved in 10% cases. This implies that involvement of hairy areas like thighs, abdomen by crab louse besides
pubic hair is more likely in males as males are hairier when compared to females. It was observed in this study
that response was good after 2 applications of permethrin/ 1% GBHC and body terminal hair removal in hairy
patients in P.Pubisinfestat
Crusted Scabies Genital Scabies
After Treatment Sarcoptesscabiei in KOH mount
6. Ectoparasites on genitalia in this Era - a study at tertiary care center in Telanganaand Review
DOI: 10.9790/0853-141212833 www.iosrjournals.org 33 | Page
P.pubis on thigh
II. Conclusion
Genital scabies is still prevalent, should be considered as differential diagnosis in all cases of
unexplained and persistant pruritus in the genital area. Every effort should be made to demonstrate P.pubis
parasite in all the patients with history of itching and something crawling sensation especially in more hairy
males and should be treated along with partners and contacts.
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