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IJRET: International Journal of Research in Engineering and Technology eISSN: 2319-1163 | pISSN: 2321-7308
_______________________________________________________________________________________
Volume: 03 Issue: 06 | Jun-2014, Available @ http://www.ijret.org 448
A REVIEW OF VARIOUS TECHNOLOGIES AND TRANSMISSION
MODES FOR DESIGN AND DEVELOPMENT OF A TRANSMISSION
ENABLED GLUCOMETER
B.G.Sudharshan1
, S.C Prasanna Kumar2
, Shashiraj Yadav R V3
1
Professor, Dept of IT, RVCE, Bangalore, India
2
HOD, Professor Dept of IT, RVCE, Bangalore, India
3
Dept of IT, RVCE, Bangalore, India
Abstract
This paper presents the various technologies used for design and development of the glucometer. It also focuses on Various
parameters such as different data acquisition methods, various microcontrollers and also different transmission capabilities used
are studied in detail. The transmission methods regularly adopted as per review are as follows 1.gsm 2.bluetooth 3.zigbee 4.wi-fi
among these the best transmission capability was found in gsm. Available software’s such as keil, c++ compiler and SQL data
base were also studied in detail to store and transmit the data. Different sensors for measurement of glucose was studied in detail
which comprised of 1.amperometric sensors2.fibreoptic sensors 3.spectroscopic sensors among them amperometric sensors were
found to be best suitable. Parameters such as data rate, range and complexity of the device are analysed.
--------------------------------------------------------------------***-----------------------------------------------------------------
1. INTRODUCTION
Diabetes is a chronic illness which requires regular
monitoring of blood glucose levels, this monitoring helps in
preventing complications. This will be fruitful if opinion can
be taken by a doctor which is not easily possible owing to
shortage of doctors especially in rural areas. This objective
of patient doctor interaction can be achieved by glucometer
having transmission capabilities.
2. DIFFERENT METHODS OF APPROACH FOR
SENSING OF GLUCOSE
The Data Acquisition Module (DAM) is composed a PIC
microcontroller [3][6]and a GSM[9][10] module The
microcontroller performs serial data transfer of patient's data
from the medical device to the GSM module. It also acts as
a temporary store for data acquired from medical devices in
case of unavailability of GSM [11] services.
The GSM module used to transfer data acquired by the
microcontroller to the doctor's mobile phone The TX and
RX pins of the GSM module are initially connected to the
microcontroller’s Universal Asynchronous Receiver/
Transmitter (UART)[6]. Such a connection allows for serial
data transfer [2][3] to the GSM module which will then
transfer data to the patient’s mobile. If the doctor cannot
handle the situation the data will be sent to the health
providers in super specialized hospital through the dbms
software [1][20]
3. AVAILABLE MICROCONTROLLERS
A microcontroller is a small low cost and self contained
computer that can be used as an embedded system. Usually
they must have low power requirements since many devices
that we control are battery operated. Hence well suited for
long lasting battery applications the types of micro
controller are characterized by their bits, memory and
instruction set namely microcontroller 8051,AVR,PIC.[6]
Usually 8051 consumes more power than AVR ,we can
program easily in AVR when compared with 8051,the speed
of AVR is better than 8051 but when we see PIC they have
much lower power consumption at 5v.usually PIC’s code is
completely efficient allowing typically less program
memory than other microcontrollers. It is of low cost and
has got high clock speed and has embedded A/D convertors
and can be used in various medical applications such as
IJRET: International Journal of Research in Engineering and Technology eISSN: 2319-1163 | pISSN: 2321-7308
_______________________________________________________________________________________
Volume: 03 Issue: 06 | Jun-2014, Available @ http://www.ijret.org 449
glucometers sphygmomanometers, pulseoximeters, Digital
thermometer, ECG.
4. GLUCOSE SENSORS REVIEW
Glucose sensors are developed based on different
technology platforms such as
Amperometric Sensors [4][7][8] – an enzymatic
electrochemical sensor was developed for continuos glucose
monitoring based on a miniaturized[7]planar.the sensor was
manufactured by using polymer film technology
Fibreoptic Sensors [4]– these sensors use the enzyme
oxidation of glucose in combination with optical oxygen
sensor as transducer. A fibre optic dual sensor setup was
integrated into a flow through cell. one sensor measures
oxygen only. while the second sensor is with an enzyme
layer. the advantage of this approach is excellent selectivity
of the oxygen optode transducer
Spectroscopic Glucose Sensor[7][8] – A mid infrared
sensor for continuos glucose monitoring in combination
with a subcutaneous or vascular body interfacewas
developed to meet the demand for reagent free assays.the
sensor is designed to ensure the utmost reliability need for
ICU.
From the types of glucose sensors discussed above the
constraint can be found in fibreoptic and spectroscopic
sensors due to their level of accuracy. The level of accuracy
is better in amperometric sensors[4][18] when compared
with the other types
5. VARIOUS WIRELESS TECHNOLOGIES
The most common types of wireless technologies used are
WI-FI - Almost everyone can access the internet in a given
area but WI-FI still requires a internet connection this is
then led to wireless router that sends and receives data to
and from mobile devices depending on the strength of WI-FI
signal this wireless technology can cover a single
house[10][17] or even a whole school campus. To increase
its range signal extenders are used[12][13]
Bluetooth – this has smallest area of effect.A Bluetooth
connection only works with a few meters it is widely used to
replace cables when transferring data.bluetooth is not ideal
when it comes to transferring large amounts of data as it
tends to be a slower and can consume a significant amount
of power[12][16]
Zigbee[10]- it is widely used today in areas where low
power consumption and low cost are absolutely necessary in
area where Bluetooth[14][15] would have proven costlier
and consumed greater power.zigbee will be able to eliminate
the necessity of cables and wires[9][10]
GSM –it usually operates in the 900 and 1800MHz
bands.thegsm user will use sim cards for the connection
with the service provider.sim cards are small in size with
removable memories and can hold a lot of data and number
of identifications which are required to access any wireless
service provider.the power consumption is usually
less[14][15]
6. AVAILABLE SOFTWARES FOR STORAGE
AND TRANSMISSION
Thekeil[20] and embedded c++ compiler supports the
microcontroller families embedded c++[20] is a subset of
the c++ programming language that is easy for c
programmers to understand and use. the embedded c++
language satisfies the requirements of embedded software
designs and avoids the overhead that is introduced eith full
c++implementations [19 ]The primary advantages of these
two softwares are Small language specification that retains
object orientated features[15],avoids excessive memory
consumption, produces predicable run time requirements,
generates ROM able code, removes non standard extensions
to c++ language features that are not authorized by
ANSI/ISO are eliminated and the web applications for
mobile phones or pc to the health provider in the super
specialist hospital the best possible applications are DBMS
preferably SQL data base[19].
IJRET: International Journal of Research in Engineering and Technology eISSN: 2319-1163 | pISSN: 2321-7308
_______________________________________________________________________________________
Volume: 03 Issue: 06 | Jun-2014, Available @ http://www.ijret.org 450
7. GLUCOMETERS AVAILABLE IN THE
MARKET [9]
8. CONCLUSIONS
Based on the review done the best possible approach for the
transmission enabled glucometer can be done by using the
amperometric glucose sensors and GSM wireless
technology and the softwareskeil,c++compiler and SQL data
base are used for storage and transmission of data
REFERENCES
[1]. S. F. CLARKE and J. R. FOSTER History Committee,
Institute of Biomedical Science, 12 Coldbath Square,
London EC1R 5H
[2]. Mike Gidley, Peter Sopade, Ghaid Al-Rabadi, Barbara
Williams and John BlackCentre for Nutrition and Food
Sciences, The University of QueenslandSt Lucia 4072and
John L Black Consulting, Locked Bag 21, Warrimoo 2774
[3]. New technologies for diabetes: a review of the present
and the future Neesha Ramchandani1 and Rubina A
Heptulla1,2*
[4]. Continuous Glucose Monitoring Systems: A Review
Sandeep Kumar Vashist HSG-IMIT—InstitutfürMikro-und
Informationstechnik, Georges-Koehler-Allee
[5]. Self-Monitoring Blood Glucose Test Systems for Over-
theCounterUseU.S. Department of Health and Human
Services Food and Drug Administration Center for Devices
and Radiological Health Office of In Vitro Diagnostic
Device Evaluation and Radiological Health Division of
Chemistry and Toxicology Devices
[6]. Use of glucometer and fasting blood glucose as
screening tools for diabetes mellitus type 2 and glycated
haemoglobin as clinical reference in rural community
primary care settings of a middle income country Benja
Muktabhant1, Pattara Sanchaisuriya1, Pongdech Sarakarn2,
Worawitaya Tawityanon3, Mantana Trakulwong3,Songsri
Worawat3,and Frank P Schelp 4*
[7]. Type 1 diabetes in adults: national clinical guideline for
diagnosis and management
[8]. Electrochemical Glucose BiosensorsJoseph Wang*
Biodesign Institute, Center for Bioelectronics and
Biosensors, Departments of Chemical Engineering and
Chemistry and Biochemistry
[9]. Glucose Biosensors: 40 Years of Advances and
Challenges Joseph Wang* Department of Chemistry and
Biochemistry, New Mexico State University, Las Cruces,
NM 88003, USA;
[10]. Investigations of foliage effect on modern wireless
communication systems: a review y. s. meng,y. h. lee
[11]. Future Electronics Egypt Ltd. (Arduino Egypt)
[12]. A Review On Improving Technologies In Wireless
Communications Parasa Sri Sai Chaitanya#1, Suresh
Angadi*2# Final Year B.Tech, Dept. Of ECE, K L
University, Vaddeswaram, Guntur, AP,
India.*Asst.professor in ECE Dept., K L University,
Vaddeswaram, Guntur, AP, India
[13]. A Comparative Study ofWirelessProtocols:Bluetooth,
UWB, ZigBee, and Wi-Fi Jin-Shyan Lee, Yu-Wei Su, and
Chung-Chou Shen Information &Communications Research
Labs Industrial Technology Research Institute (ITRI)
Hsinchu, Taiwan
[14]. Communication Technologies and their Applications
beyond Communication Simon Mayer Department of
Computer Science, ETH Zurich
[15]. IJCSI International Journal of Computer Science
Issues,July 2011
[16]. a) D. Gough, J. Lucisano, P. Tse, Anal. Chem. 1985,
57, 2351b) J. Armour, J. Lucisano, D. Gough,Diabetes1990,
39, 1519.
[17]. Goldstein DE, Little RR, Lorenz RA, Malone JI,
Nathan D, Peterson CM:Tests of glycemia in
diabetes.Diabetes Care1995,
[18]. Simmons RK, Unwin N, Griffin SJ:International
Diabetes Federation: An update of the evidence concerning
the prevention of type 2 diabetes.Diabetes Res Clin
Pract2010,
[19]. DBMS in bioinformatics
[20]. www.Embedded softwares.com

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A review of various technologies and transmission modes for design and development of a transmission enabled glucometer

  • 1. IJRET: International Journal of Research in Engineering and Technology eISSN: 2319-1163 | pISSN: 2321-7308 _______________________________________________________________________________________ Volume: 03 Issue: 06 | Jun-2014, Available @ http://www.ijret.org 448 A REVIEW OF VARIOUS TECHNOLOGIES AND TRANSMISSION MODES FOR DESIGN AND DEVELOPMENT OF A TRANSMISSION ENABLED GLUCOMETER B.G.Sudharshan1 , S.C Prasanna Kumar2 , Shashiraj Yadav R V3 1 Professor, Dept of IT, RVCE, Bangalore, India 2 HOD, Professor Dept of IT, RVCE, Bangalore, India 3 Dept of IT, RVCE, Bangalore, India Abstract This paper presents the various technologies used for design and development of the glucometer. It also focuses on Various parameters such as different data acquisition methods, various microcontrollers and also different transmission capabilities used are studied in detail. The transmission methods regularly adopted as per review are as follows 1.gsm 2.bluetooth 3.zigbee 4.wi-fi among these the best transmission capability was found in gsm. Available software’s such as keil, c++ compiler and SQL data base were also studied in detail to store and transmit the data. Different sensors for measurement of glucose was studied in detail which comprised of 1.amperometric sensors2.fibreoptic sensors 3.spectroscopic sensors among them amperometric sensors were found to be best suitable. Parameters such as data rate, range and complexity of the device are analysed. --------------------------------------------------------------------***----------------------------------------------------------------- 1. INTRODUCTION Diabetes is a chronic illness which requires regular monitoring of blood glucose levels, this monitoring helps in preventing complications. This will be fruitful if opinion can be taken by a doctor which is not easily possible owing to shortage of doctors especially in rural areas. This objective of patient doctor interaction can be achieved by glucometer having transmission capabilities. 2. DIFFERENT METHODS OF APPROACH FOR SENSING OF GLUCOSE The Data Acquisition Module (DAM) is composed a PIC microcontroller [3][6]and a GSM[9][10] module The microcontroller performs serial data transfer of patient's data from the medical device to the GSM module. It also acts as a temporary store for data acquired from medical devices in case of unavailability of GSM [11] services. The GSM module used to transfer data acquired by the microcontroller to the doctor's mobile phone The TX and RX pins of the GSM module are initially connected to the microcontroller’s Universal Asynchronous Receiver/ Transmitter (UART)[6]. Such a connection allows for serial data transfer [2][3] to the GSM module which will then transfer data to the patient’s mobile. If the doctor cannot handle the situation the data will be sent to the health providers in super specialized hospital through the dbms software [1][20] 3. AVAILABLE MICROCONTROLLERS A microcontroller is a small low cost and self contained computer that can be used as an embedded system. Usually they must have low power requirements since many devices that we control are battery operated. Hence well suited for long lasting battery applications the types of micro controller are characterized by their bits, memory and instruction set namely microcontroller 8051,AVR,PIC.[6] Usually 8051 consumes more power than AVR ,we can program easily in AVR when compared with 8051,the speed of AVR is better than 8051 but when we see PIC they have much lower power consumption at 5v.usually PIC’s code is completely efficient allowing typically less program memory than other microcontrollers. It is of low cost and has got high clock speed and has embedded A/D convertors and can be used in various medical applications such as
  • 2. IJRET: International Journal of Research in Engineering and Technology eISSN: 2319-1163 | pISSN: 2321-7308 _______________________________________________________________________________________ Volume: 03 Issue: 06 | Jun-2014, Available @ http://www.ijret.org 449 glucometers sphygmomanometers, pulseoximeters, Digital thermometer, ECG. 4. GLUCOSE SENSORS REVIEW Glucose sensors are developed based on different technology platforms such as Amperometric Sensors [4][7][8] – an enzymatic electrochemical sensor was developed for continuos glucose monitoring based on a miniaturized[7]planar.the sensor was manufactured by using polymer film technology Fibreoptic Sensors [4]– these sensors use the enzyme oxidation of glucose in combination with optical oxygen sensor as transducer. A fibre optic dual sensor setup was integrated into a flow through cell. one sensor measures oxygen only. while the second sensor is with an enzyme layer. the advantage of this approach is excellent selectivity of the oxygen optode transducer Spectroscopic Glucose Sensor[7][8] – A mid infrared sensor for continuos glucose monitoring in combination with a subcutaneous or vascular body interfacewas developed to meet the demand for reagent free assays.the sensor is designed to ensure the utmost reliability need for ICU. From the types of glucose sensors discussed above the constraint can be found in fibreoptic and spectroscopic sensors due to their level of accuracy. The level of accuracy is better in amperometric sensors[4][18] when compared with the other types 5. VARIOUS WIRELESS TECHNOLOGIES The most common types of wireless technologies used are WI-FI - Almost everyone can access the internet in a given area but WI-FI still requires a internet connection this is then led to wireless router that sends and receives data to and from mobile devices depending on the strength of WI-FI signal this wireless technology can cover a single house[10][17] or even a whole school campus. To increase its range signal extenders are used[12][13] Bluetooth – this has smallest area of effect.A Bluetooth connection only works with a few meters it is widely used to replace cables when transferring data.bluetooth is not ideal when it comes to transferring large amounts of data as it tends to be a slower and can consume a significant amount of power[12][16] Zigbee[10]- it is widely used today in areas where low power consumption and low cost are absolutely necessary in area where Bluetooth[14][15] would have proven costlier and consumed greater power.zigbee will be able to eliminate the necessity of cables and wires[9][10] GSM –it usually operates in the 900 and 1800MHz bands.thegsm user will use sim cards for the connection with the service provider.sim cards are small in size with removable memories and can hold a lot of data and number of identifications which are required to access any wireless service provider.the power consumption is usually less[14][15] 6. AVAILABLE SOFTWARES FOR STORAGE AND TRANSMISSION Thekeil[20] and embedded c++ compiler supports the microcontroller families embedded c++[20] is a subset of the c++ programming language that is easy for c programmers to understand and use. the embedded c++ language satisfies the requirements of embedded software designs and avoids the overhead that is introduced eith full c++implementations [19 ]The primary advantages of these two softwares are Small language specification that retains object orientated features[15],avoids excessive memory consumption, produces predicable run time requirements, generates ROM able code, removes non standard extensions to c++ language features that are not authorized by ANSI/ISO are eliminated and the web applications for mobile phones or pc to the health provider in the super specialist hospital the best possible applications are DBMS preferably SQL data base[19].
  • 3. IJRET: International Journal of Research in Engineering and Technology eISSN: 2319-1163 | pISSN: 2321-7308 _______________________________________________________________________________________ Volume: 03 Issue: 06 | Jun-2014, Available @ http://www.ijret.org 450 7. GLUCOMETERS AVAILABLE IN THE MARKET [9] 8. CONCLUSIONS Based on the review done the best possible approach for the transmission enabled glucometer can be done by using the amperometric glucose sensors and GSM wireless technology and the softwareskeil,c++compiler and SQL data base are used for storage and transmission of data REFERENCES [1]. S. F. CLARKE and J. R. FOSTER History Committee, Institute of Biomedical Science, 12 Coldbath Square, London EC1R 5H [2]. Mike Gidley, Peter Sopade, Ghaid Al-Rabadi, Barbara Williams and John BlackCentre for Nutrition and Food Sciences, The University of QueenslandSt Lucia 4072and John L Black Consulting, Locked Bag 21, Warrimoo 2774 [3]. New technologies for diabetes: a review of the present and the future Neesha Ramchandani1 and Rubina A Heptulla1,2* [4]. Continuous Glucose Monitoring Systems: A Review Sandeep Kumar Vashist HSG-IMIT—InstitutfürMikro-und Informationstechnik, Georges-Koehler-Allee [5]. Self-Monitoring Blood Glucose Test Systems for Over- theCounterUseU.S. Department of Health and Human Services Food and Drug Administration Center for Devices and Radiological Health Office of In Vitro Diagnostic Device Evaluation and Radiological Health Division of Chemistry and Toxicology Devices [6]. Use of glucometer and fasting blood glucose as screening tools for diabetes mellitus type 2 and glycated haemoglobin as clinical reference in rural community primary care settings of a middle income country Benja Muktabhant1, Pattara Sanchaisuriya1, Pongdech Sarakarn2, Worawitaya Tawityanon3, Mantana Trakulwong3,Songsri Worawat3,and Frank P Schelp 4* [7]. Type 1 diabetes in adults: national clinical guideline for diagnosis and management [8]. Electrochemical Glucose BiosensorsJoseph Wang* Biodesign Institute, Center for Bioelectronics and Biosensors, Departments of Chemical Engineering and Chemistry and Biochemistry [9]. Glucose Biosensors: 40 Years of Advances and Challenges Joseph Wang* Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, NM 88003, USA; [10]. Investigations of foliage effect on modern wireless communication systems: a review y. s. meng,y. h. lee [11]. Future Electronics Egypt Ltd. (Arduino Egypt) [12]. A Review On Improving Technologies In Wireless Communications Parasa Sri Sai Chaitanya#1, Suresh Angadi*2# Final Year B.Tech, Dept. Of ECE, K L University, Vaddeswaram, Guntur, AP, India.*Asst.professor in ECE Dept., K L University, Vaddeswaram, Guntur, AP, India [13]. A Comparative Study ofWirelessProtocols:Bluetooth, UWB, ZigBee, and Wi-Fi Jin-Shyan Lee, Yu-Wei Su, and Chung-Chou Shen Information &Communications Research Labs Industrial Technology Research Institute (ITRI) Hsinchu, Taiwan [14]. Communication Technologies and their Applications beyond Communication Simon Mayer Department of Computer Science, ETH Zurich [15]. IJCSI International Journal of Computer Science Issues,July 2011 [16]. a) D. Gough, J. Lucisano, P. Tse, Anal. Chem. 1985, 57, 2351b) J. Armour, J. Lucisano, D. Gough,Diabetes1990, 39, 1519. [17]. Goldstein DE, Little RR, Lorenz RA, Malone JI, Nathan D, Peterson CM:Tests of glycemia in diabetes.Diabetes Care1995, [18]. Simmons RK, Unwin N, Griffin SJ:International Diabetes Federation: An update of the evidence concerning the prevention of type 2 diabetes.Diabetes Res Clin Pract2010, [19]. DBMS in bioinformatics [20]. www.Embedded softwares.com