Retention in complete dentures is influenced by physical, biologic, chemical, psychological, and mechanical factors. Physical factors include adhesion, cohesion, capillarity and atmospheric pressure. Biologic factors involve neuromuscular control, saliva, mucosal health, and ridge characteristics. Denture adhesives are a chemical method to enhance retention. Retentive features like magnets, implants, and ultra suction chambers are mechanical approaches. Proper consideration of all relevant factors leads to optimal complete denture retention.