7 Cloacal Exstrophy Des
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Cloacal exstrophy is a rare birth defect that affects the pelvis and genitals. For genetic males born with this condition, it has been advocated to assign them a female sex at birth through surgery. However, some studies have found that some of these individuals later identify as male despite being raised as female. This suggests that prenatal androgen exposure plays a role in sexual identity development.
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![Cloacal Exstrophy Treatment of Genetic Males ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Reiner, William G. and Gearhart, John P. Discordant Sexual Identity in Some Genetic Males with Cloacal Exstrophy Assigned to Female Sex at Birth. THE NEW ENGLAND JOURNAL OF MEDICINE, 350:333-341 (2004)](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
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Intersex
1. Intersex conditions occur when there is discordance between chromosomal, gonadal, internal genital, and phenotypic sex or the sex of rearing.
2. The most common cause of intersex conditions is congenital adrenal hyperplasia, which accounts for about 98% of cases.
3. Proper evaluation and management of intersex conditions in newborns requires a multidisciplinary team to determine the diagnosis, consider sex of rearing, and plan for any necessary reconstructive surgery.
1 How Many Sexes Are There
Part 1 of "Science & Sexuality." You don't believe that "Adam and Eve" story, do you? Did Eve come from Adam? Or did Adam come from Eve? This is a physiologist's refutation of the biblical binary sexual system. Click on the next 9 slideshows in numerical order for the rest of this scientific update on human sexuality.
Gynecology 5th year, 3rd lecture (Dr. Maryam)
There are three factors that determine sexual development: 1) effect of sex chromosomes on gonad differentiation, 2) proper functioning of differentiating testes, and 3) response of end organs to testicular function. Sexual development is determined at fertilization by the presence or absence of the Y chromosome, which leads to development of testes or ovaries respectively and the subsequent development of internal and external genitalia through hormone production and response. Disorders of sexual development can occur if there are issues in gonad differentiation or hormone production and response.
Reproductive Genetics and the Aging Male
American Urological Association (AUA) Lecture given at the American Society of Andrology (ASA) 40th annual conference, April 18 – 21, 2015 in Salt Lake City, Utah.
Ambiguous genitalia
This document discusses disorders of sex development (DSD), formerly known as intersex conditions. It begins with definitions of DSD and describes when to suspect DSD based on physical examination findings in newborns. It then discusses the various types of DSD classified by chromosomal, gonadal and phenotypic sex, including 46,XX virilized females, 46,XY undervirilized males, gonadal differentiation disorders, and syndromes associated with ambiguous genitalia. The document reviews DSD embryology and hormone biosynthesis pathways. It provides guidance on the evaluation, diagnosis and management of DSD through history, physical exam, imaging, genetic and hormonal testing, and the roles of the multidisciplinary DSD team.
Male Animal infertility
The document discusses infertility in male animals, defining it as delayed or irregular reproduction or inability to conceive. It identifies several causes of infertility including hereditary, congenital, genetic, infectious, nutritional, hormonal, and miscellaneous factors. Specific conditions that can cause infertility are then outlined relating to the testes, epididymis, sperm defects, and other anatomical abnormalities. Genetic factors involved in meiotic defects, spermatogenic arrest, sperm-egg interaction, and structural defects are also reviewed.
Disorder of Sex Differentiattion ( ambiguos genitelia )
Disorders of sex development (DSD) occur when the development of chromosomal, gonadal, or anatomical sex is atypical. Evaluation of DSD involves a physical exam, karyotype testing, hormone level testing, and imaging exams. Diagnosis is made based on gonadal status and further tests can include hormone stimulation tests, biopsy of gonads, and genetic analysis. Treatment is determined based on diagnosis and may include surgery and hormone replacement therapy.
Androgen+Insensitivity
Androgen Insensitivity Syndrome (AIS) is a genetic condition where people have male chromosomes and male gonads but experience partial or complete feminization of the external genitals. It is caused by mutations in the androgen receptor gene that results in cells not responding properly to androgens like testosterone. People with AIS show a spectrum of physical traits from fully female to ambiguous external genitalia depending on the severity of the mutation. Testing and treatment involves genetic testing, surgery, and hormone replacement therapy, while psychological support is also important.
Intersex ppt by arch
This document discusses congenital adrenal hyperplasia (CAH), which is caused by a deficiency in enzymes involved in cortisol production. The most common type is 21-hydroxylase deficiency, which accounts for over 90% of cases. This type results in excess androgen production that can virilize female genitalia in utero. The document defines the different types of CAH based on the deficient enzyme. It also describes the genetic basis, clinical manifestations, diagnosis, and treatment of the different forms, with a focus on 21-hydroxylase deficiency CAH.
Intersex people
Who is intersex? What are the types of intersex? Is intersexuality natural? What concerns are shared by LGBT people and intersex people? Learn why you should care about intersex people!
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Anormal Seksüel Gelişim - İntersexuality - www.jinekolojivegebelik.com
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Disorder of Sex Differentiattion ( ambiguos genitelia )
Disorder of Sex Differentiattion ( ambiguos genitelia )
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The Gender Binary & LGBTI People: Religious Myth and Medical Malpractice
Designated as disordered rather than just different, LGBTI people have been and continue to be victims of medical malpractice purely because they are neither Adams nor Eves. Psychiatrists, surgeons, endocrinologists, pediatricians, and other medical experts have subjected LGBTI people to bogus and horrific treatments with reckless disregard for patient health and well-being―all the while ignoring the basic tenets of medical ethics and the ever-growing scientific evidence showing LGBTI people to be natural variations. Beyond this, medical stigmatization of LGBTI people has contributed to their oppression in the world at large. This treatise will contrast the scientific evidence with the ongoing medical (mis)treatment of LGBTI people to vividly illustrate the insidious effect of the biblical creation myth.
This presentation is from Chapter 12 of the anthology Christianity Is Not Great: How Faith Fails. John W. Loftus (editor), (Amherst NY: Prometheus Books, 2014).
Paperback or Kindle version of the book here.
http://www.amazon.com/Christianity-Is-Not-Great-Faith/dp/1616149566
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Who is intersex? What are the kinds of intersex? What has the medical profession been doing to intersex folks?
Gender Binary & LGBTI People - Myth and Medical Malpractice
Medical mistreatment of lesbian, gay, bisexual, transgender, and intersex people because they are neither Adams nor Eves! An update on the science versus the medical practice concerning sexuality from a physiologist’s perspective.
An audio recording that accompanies this slideshow can be found at:
http://freethoughtfestival.org/audio/FTF120427Drantz-ed.mp3
Better yet, watch the video in which I explain the slides as you look at them.
http://drdrantz-sciencesexuality.blogspot.com/2012/07/video-gender-binary-lgbti-people-myth.html
INTERSEX LIVES
This document discusses intersex lives and identities. It begins by defining intersex as those who are not clearly male or female, and notes that as many as 4% of people are intersex. It discusses how sex is determined by chromosomes, hormones, gonads and genitals, and notes there is a spectrum rather than a strict binary. The document challenges the idea of a gender binary and the notion that gender identity is solely socially constructed. It discusses how prenatal hormones influence brain development and later behaviors and identities, as seen in cases like David Reimer, who was raised as a girl but identified as a boy.
Myth & Science of Sexuality
This slideshow “Myth and Science of Sexuality - Disordered or Just Different?” presented to the Ethical Humanist Society of Chicago on October 10, 2010., explains the development of diverse sexualities (as natural variations of the organization-activation mechanism) and shows that LGBTI peoples suffer persecution due to a socio-cultural disorder stemming from the erroneous “gender binary” concept.
Myth and science of sexuality short
This presentation explains the development of diverse sexualities (as natural variations of the organization-activation mechanism), and shows that LGBTI peoples suffer from a socio-cultural disorder that results from the erroneous "gender binary" concept.
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Learn why the biblical binary sexual system is unnatural! A physiologist’s perspective on core sexuality: sexual identity, sexual orientation, sex versus gender, anthropological observations. “Disordered or Just Different” culminates with a scientific indictment of the (pseudo)medical practitioners who are too quick to classify the merely different as disordered and who continue to harm gay, lesbian, transsexual, and intersex peoples.
2 The Sexual Brain
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3 Sex Hormones
This document discusses hormones that influence sex development, including testosterone, dihydrotestosterone, and estrogens. It describes how testosterone is converted to dihydrotestosterone via the 5-alpha reductase enzyme and can be converted to estrogens via the aromatase enzyme. The aromatase enzyme is found in the brain and its expression can permanently alter brain development and sexual behavior.
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