The document discusses factors that influence functional health and disability in older adults. It presents a model of the disablement process and examines how chronic conditions, socioeconomic status, gender, and ethnicity can impact functional limitations and the need for assistance with daily activities. Common causes of disability in older adults include cerebrovascular disease, arthritis, smoking, physical inactivity, and depression.
Clarity in the curriculum: Using Constructive Alignment to improve your moduleEmma Kennedy
This workshop was delivered at a meeting of the German Academic Exchange (DAAD) in December 2016. It focuses on aligning the higher education curriculum at module and session levels.
Clarity in the curriculum: Using Constructive Alignment to improve your moduleEmma Kennedy
This workshop was delivered at a meeting of the German Academic Exchange (DAAD) in December 2016. It focuses on aligning the higher education curriculum at module and session levels.
Buyuk Oyun - Ozgur Uckan & Huseyin Alptekin Kitap-lık - 1997Ozgur Uckan
20. yüzyıl başının Büyük Oyun / Le Grand Jeu dergisi ve edebiyat akımı hakkında Özgür Uçkan ve Hüseyin Alptekin tarafından Kitap-lık dergisinde 1997'de yayınlanmış yazılar
Buyuk Oyun - Ozgur Uckan & Huseyin Alptekin Kitap-lık - 1997Ozgur Uckan
20. yüzyıl başının Büyük Oyun / Le Grand Jeu dergisi ve edebiyat akımı hakkında Özgür Uçkan ve Hüseyin Alptekin tarafından Kitap-lık dergisinde 1997'de yayınlanmış yazılar
"Reintegrating Returning Warriors and The Subtleties of PTSD: Practice, Research and Policy"
by Col Jeffrey Yarvis, Chief of Soldier Behavioral Health Service, Carl R. Darnall Army Medical Center, Washington DC
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
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2. Learning Objectives
What are the average and maximum longevity for
humans?
What genetic and environmental factors influence
longevity?
What ethnic factors influence average longevity?
What factors create gender differences in average
longevity?
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4. Maximum Longevity
House mouse, 4
Dogs, 29
Cats, 36
Polar bears, 42
Horses, 62
Chimpanzees, 59
Average and Maximum Longevity For Asian elephants, 86
Average Longevity – age at which half the
individuals born in a particular year will have died.
Maximum Longevity – the oldest age to which any
individual of a species lives.
What is the difference between active life
expectancy and dependent life expectancy?
The difference between living to a healthy old age and simply living a long time.
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5. Genetic and Environmental
Factors in Average Longevity
Genetic Factors
Family History
Can’t pick your history
Environmental Factors
Disease
Toxins
Lifestyle
Social class 121
We can control most Jeanne Calment
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6. Ethnic Differences
Are ethnic differences associated with genetics? Is
that the only association?
The differences are complex.
Sociocultural, economic conditions, healthcare disease, etc
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7. Gender Differences in Average Longevity
Women have nearly a seven year edge over men.
Why?
Men are more vulnerable to disease than women.
Men are risk-takers.
Men smoke and use alcohol more than women.
Men allow stress to enter their lives more than women.
Anything else?
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8. International Differences
Dramatic Differences in Longevity Around the
World
From 38 years in Sierra Leone, West Africa to 80 years in
Japan
Factors
Genetic
Sociocultural
Economic 111
Anything else?
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10. Learning Objectives
What are the key issues in defining health and
illness?
How is quality of life assessed?
What normative age-related changes occur in the
immune system?
What are the developmental trends in chronic and
acute diseases?
What are the key issues in stress across adulthood?
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11. Defining Health and Illness
Health – A state of
complete physical, mental,
and social well-being, and
not just the absence of
disease or impairment.
Illness – Presence of a
physical or mental disease
or impairment.
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12. Quality of Life
Relating to specific diseases or conditions
To what extent does distress from illness or side effects
associated with treatment reduce the person’s will to live?
Valuation of life – value placed on staying alive
Relating to end-of-life issues
How much one enjoys life, has hope
for the future, and finds meaning in
every day events, determines how
long a person wants to live.
Quality of life – one’s perception of their
position in life in context of their culture
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13. Changes in the Immune System
How does the defense system work?
How does aging affect the immune system?
Not well understood; more susceptible to infection and cancer
Aging is related to how well the system works.
Autoimmunity
Immune system can attack the body itself.
Rheumatoid arthritis
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14. Changes in the Immune System – cont.
Psychoneuroimmunology
Psychology
Neurological
Immunological system changes
(Cohen & Herbert, 1996)
AIDS and Older Adults
15,000 people over 65 have AIDS (CDC, 2008)
Rapid progression from HIV positive to AIDS
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15. Chronic and Acute Diseases
Acute Diseases
Conditions that develop over a short period of time and cause a
rapid change in health.
Example: UTI, strep
Go down in the elderly
Chronic Diseases
Conditions that last a long time (min. 3 mo.) and may be
accompanied by residual functional impairment that necessitates
long-term management.
Example: arthritis and diabetes
Goes up in the elderly
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16. The Role of Stress – bad for your health in the long run
Stress as a Physiological State
Sympathetic nervous system
(heart rate, respiration, blood flow, muscle strength, etc)
Impaired immune system, increase risk of cardiovascular
disease, increase risk of cancer
Gender differences? Men want to be alone, women want
to be with other people. (fight or flight vs. tend and befriend)
Stress and Coping Paradigm
Interaction of a thinking person and an event
(People experience stress differently)
Two people stuck in traffic – different levels of stress. Why?
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18. The Role of Stress (cont.)
Appraisal (Lazarus and Folkman, 1984)
Primary appraisal: categorize the event
Secondary appraisal: evaluate the event
Reappraisal: changes in the situation may change the
appraisal
Coping – dealing with stressful events
Death of a spouse
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19. The Role of Stress
Aging, Stress and Coping
Who has more stress? Older or Younger?
Management strategies
Avoid stressful situations
Change thinking about the situation
Relaxation techniques --- deep breathing
--- Progressive Muscle Relaxation
--- visualization
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20. Effects of Stress on Health
Short-term stress vs. long-term stress
Chronic Stress
Immune system suppression
Increased susceptibility to:
Viral infections
Risk of atherosclerosis
Hypertension
Impaired memory and cognition
Inhibited menstruation – women
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21. Learning Objectives
What are the most important issues in chronic
disease?
What are some common chronic conditions across
adulthood?
How can people manage chronic conditions?
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22. General Issues in Chronic Conditions
Common Chronic Conditions
Arthritis
Cardiovascular and Cerebrovascular Disease
(leading cause of death in US)
Diabetes Mellitus
Cancer
(2nd leading cause of death in US)
Risk increases with age – males at greater risk
Incontinence
More embarrassing than dangerous
15% community dwelling elders
35% community dwelling elders with dementia
70% nursing home residents
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26. Managing Pain
Myths and Stereotypes
Part of growing old
Elders should just accept the pain
How to manage pain?
Pharmacological
More meds than any other age group
½ all meds prescribed
Non-pharmacological
Therapeutic touch, massage, vibration, heat, cold
Acupuncture and acupressure
Biofeedback
Distraction techniques
Relaxation, meditation, and imagery
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27. Learning Objectives
What are the developmental trends in using
medication?
How does aging affect the way the medications work?
What are the consequences of medication
interactions?
What are the important medication adherence issues?
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28. Patterns of Medication Use
Explosion of new medication available
People over 60 take nearly 50% of all prescription and over
the counter medication.
New drugs can be dangerous to older adults.
New drugs are frequently very expensive.
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29. Developmental Changes and Medication
Absorption
Time needed for medications to enter the bloodstream
Once in the bloodstream the drug is distributed
throughout the body.
Drug Metabolism
Drug Excretion
Drugs not recommended for older adults
Good strategy: “start low and go slow.”
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30. Medication Side Effects and Interactions
Polypharmacy
The use of multiple medications in the same person
Interactions
Potentially dangerous
Adherence to Medication Regimens
Difficult with older patients
Many older patients go to more than one doctor so
accurate knowledge of drugs taken is important.
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33. Functional Health and Disability
Learning Objectives
What factors are important to include in a model of
disability in late life?
What is functional health?
What causes functional limitations and disability in
older adults?
Britain's Oldest Married Couple
Ralph – 107
Phyllis – 101
Married – 77 years
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34. Functional Health and Disability
Disability in Late Life
Definition of disability?
Effects of a chronic condition on a person’s ability to engage in activities
that are necessary, expected, or desired in their society
Compression of morbidity
Becoming disabled later with a shorter period of disability before death
A model of the disablement process
Interventions strategies:
Extraindividual factors – environmental & healthcare
(surgery, meds, social support services, physical environment support)
Intraindividual factors – behavioral & personality
(exercising, positive outlook,etc)
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36. Functional Health and Disability
Determining Functional Health Status
Determining Functional Health Status
Frail older adults
physical disabilities, very ill, cognitive decline or psychological
disorders, and need assistance with everyday tasks
*(minority of older adults; chance increases with age)
*Needs help with more than one ADL
Activities of daily living: ADL
basic self-care task – eating, dressing, bathing, toileting, walking
Instrumental activities of daily living: IADL
actions requiring planning & intellectual competence
(shopping, paying bills, taking meds correctly, keeping appointments)
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37. Functional Health and Disability
Limitations and Disability in Older Adults?
Strong predictors
Cerebrovascular disease
Arthritis
Coronary artery disease (weaker predictor)
Other predictors
Smoking
Heavy drinking
Physical inactivity
Depression
Social isolation and perceived poor health
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40. Functional Health and Disability
What Causes Functional Limitations
and Disability in Older Adults?
How Important are Socioeconomic Factors?
Do Gender and Ethnicity Matter?
Britain's Oldest Married Couple
Ralph – 107
Phyllis – 101
Married – 77 years
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