3. rifampicin urine
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This document discusses different causes of urine discoloration, distinguishing between hematuria (blood in urine) and non-hematuria causes. It emphasizes the importance of determining whether urine discoloration stems from hematuria, which can indicate serious systemic or renal issues, or non-hematuria causes like concentrated urine, myoglobin release, diet, drugs, and dyes. The document specifically examines a case where a patient taking the antibiotic rifampicin for TB treatment experienced orange urine discoloration, as rifampicin is known to sometimes cause this side effect.
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Among the factors that lead to the occurrence of gastrointestinal infections are the hygienic and sanitary deficiencies that characterize our markets and other places where raw or cooked food is sold, poor environmental sanitation in communities, deficiencies in water treatment (or in the process of its plumbing), risky hygienic-sanitary habits (not washing hands after major and/or minor needs), among others.
These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
To prevent this, it is necessary to promote health education, improve the hygienic-sanitary conditions of markets and communities in general as a way of promoting, preserving and prolonging PUBLIC HEALTH.
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Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
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Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
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- 1. Image of The Day 3: Orange Discoloration of Urine Muhamad Na’im B. Ab Razak (MD USM) In approaching patient with urine discoloration, it is very important to distinguish whether the urine discoloration is caused by hematuria or non hematuria urine discoloration. Hematuria could be due to many causes either from systemic, renal, ureter, bladder, prostate or urethra. It signifies a serious condition and need a very serious attention. In a meantime, it is important not to confuse yourself with a non hematuria causes of urine discoloration which of course less important as compared to haematuria. Urine discoloration could be due to many things starting from concentrated urine, increase in tissue breakdown that release myoglobin, dye, diet and drugs. This picture highlight an orange urine discoloration in a patient with TB spine who receive Rifampicin. Rifampicin is a broad spectrum bactericidal antibiotic which inhibit the synthesis of bacterial RNA by binding to the beta subunit of the DNA- dependent RNA polymerase. This will block the transcription of the RNA. This traditional antibiotic has been used since ages to treat tuberculosis, leprosy and oppurtunistic mycobacterial infection.