Asccp management guidelines august 2014 ppt. Dr. Sharda Jain /Dr Jyoti Agarw...Lifecare Centre
Updated Consensus
American society of Colpscopy & cervical pathology
Guidelines 2014 for Managing for Abnormal Cervical Cancer Screening Test and Cancer Precursors
Dr. Sharda Jain /Dr Jyoti Agarwal / dr. Jyoti Bhasker
Current knowledge and state of the art about management of abnormal cervical Cancer screening tests and cancer precursors for health providers in low-income settings is presented.
HPV Testing is essential in the triage of ASC-US and/or LSIL cytology. The test helps to clearify the situation after treatment of high-grade CIN and to resolve uncertainties after diagnostic and or consecutive treatment. 2016 up to date information is give by the presentation.
Primary HPV testing or co-testin
Basics To Ca Cx Screening (Eastern Biotech)Pankaj Sohaney
Detecting HPV means better understanding of the risk of cervical cancer was the major focus of Dr. Dinesh Gupta. He spoke on “Opportunistic Screening for Cervical Precancer Lesions” and informed why the combination screening is vital for prevention and detection of cervical cancer. According to Dr. Gupta, combined screening with liquid based cytology and hybrid capture2 HPV DNA test would identify who’s at risk for high-grade disease and cancer and reduce missed disease caused by false-negative Pap Smear. HPV DNA test is the only FDA approved test to detect 13 high risk HPVs associated with virtually all cervical cancer, he added.
Nulife module 6 screening for malignancies editedManinder Ahuja
These six modules from 2-7 are on mid life health care of women and were made with intention of training general gynecologist and other speciality into care of mid life women and have Mid Life OPD cards as mainstay of care.
All the guidelines recommend co testing as the modality of choice for cervical cancer screening.
However, Cobas test was approved by FDA as primary screening modality in 2014.
The Accuracy of Diagnostic Colposcopy using IFCPC 2011 TerminologySujoy Dasgupta
This paper was presented in the Annual Conference of Bengal Obstetric and Gynaecological Society (BOGSCON) 2014 held at ITC Sonar, Kolkata- January, 2014
Asccp management guidelines august 2014 ppt. Dr. Sharda Jain /Dr Jyoti Agarw...Lifecare Centre
Updated Consensus
American society of Colpscopy & cervical pathology
Guidelines 2014 for Managing for Abnormal Cervical Cancer Screening Test and Cancer Precursors
Dr. Sharda Jain /Dr Jyoti Agarwal / dr. Jyoti Bhasker
Current knowledge and state of the art about management of abnormal cervical Cancer screening tests and cancer precursors for health providers in low-income settings is presented.
HPV Testing is essential in the triage of ASC-US and/or LSIL cytology. The test helps to clearify the situation after treatment of high-grade CIN and to resolve uncertainties after diagnostic and or consecutive treatment. 2016 up to date information is give by the presentation.
Primary HPV testing or co-testin
Basics To Ca Cx Screening (Eastern Biotech)Pankaj Sohaney
Detecting HPV means better understanding of the risk of cervical cancer was the major focus of Dr. Dinesh Gupta. He spoke on “Opportunistic Screening for Cervical Precancer Lesions” and informed why the combination screening is vital for prevention and detection of cervical cancer. According to Dr. Gupta, combined screening with liquid based cytology and hybrid capture2 HPV DNA test would identify who’s at risk for high-grade disease and cancer and reduce missed disease caused by false-negative Pap Smear. HPV DNA test is the only FDA approved test to detect 13 high risk HPVs associated with virtually all cervical cancer, he added.
Nulife module 6 screening for malignancies editedManinder Ahuja
These six modules from 2-7 are on mid life health care of women and were made with intention of training general gynecologist and other speciality into care of mid life women and have Mid Life OPD cards as mainstay of care.
All the guidelines recommend co testing as the modality of choice for cervical cancer screening.
However, Cobas test was approved by FDA as primary screening modality in 2014.
The Accuracy of Diagnostic Colposcopy using IFCPC 2011 TerminologySujoy Dasgupta
This paper was presented in the Annual Conference of Bengal Obstetric and Gynaecological Society (BOGSCON) 2014 held at ITC Sonar, Kolkata- January, 2014
Given the availability of a colposcope and a trained colposcopist this method is an essential tool for effective secondary prevention of female reproductive organ diseases. Colposcopic guided procedures enable a preceise diagnostic and consequent treatments with eventually organ preserving means. This power point presentation highlights the range of opportunities offered by Colposcopy.
Colposcopy training part 1 ,DR. SHARDA JAIN Dr. Jyoti Agarwal / Dr. Jyoti Bha...Lifecare Centre
Definition used in the consensus guidelines ASCCP +24 organizations 2013
Colposcopy
Colposcopy is the examination of the cervix , vagina and, in some instances the vulva, with the colposcope after the application of a 3--5% acetic solution coupled with obtaining colposcopically – directed biopsies of all lesions suspected of representing neoplasia
Recurrent pregnancy loss - Uterine factorsAnu Manivannan
recurrent pregnancy loss - uterine factors based on fertility sterility journal - evidence based
Dr.Anu.M - Mch Resident - Department of Reproductive Medicine and Surgery
Austin Journal of Clinical Case Reports is an open access scholarly journal. The goal of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments by publishing case reports in all aspects of Clinical Medicine. Case Reports is an open access journals. The goal of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments by publishing case reports in all aspects of Clinical Medicine.
The aim of this open access journal is to offer service for scientists and academicians to promote, share, and discuss various new issues and developments by publishing clinical case reports in all aspects.
Austin Journal of case repots are a reflective analysis of one, two, or three clinical cases. All clinical case reports submitted must have been approved by an ethics committee or institutional review board.
Austin Journal of Clinical Case Reports is an open access scholarly journal. The goal of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments by publishing case reports in all aspects of Clinical Medicine. Case Reports is an open access journals. The goal of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments by publishing case reports in all aspects of Clinical Medicine.
Pedunculated Lipoma of the Caecum Causing Colocolic Intussusception in an AdultKETAN VAGHOLKAR
Introduction: Colocolic intussusception in adults is uncommon and poses both a diagnostic
and therapeutic dilemma. The association of an underlying malignancy necessitates a preoperative
confirmation of diagnosis. The presenting features are variable. Hence contrast enhanced
computed tomography of the abdomen is pivotal for diagnosis. An en bloc resection
of the specimen in accordance with standard oncological principles is the mainstay of treatment.
Case report: A case of colocolic intussusception in an adult is presented to highlight the
difficulties in preoperative diagnosis and in selecting the best surgical option for treatment.
Conclusion: Adult bowel intussusception is a diagnostic dilemma with preoperative diagnosis
being the biggest challenge. CT scan of the abdomen is an excellent diagnostic modality with
high diagnostic accuracy. Explorative laparotomy with en bloc resection is mainstay of treatment
in adults.
Manegement of adenexal masses in pregnancyWafaa Benjamin
Over the last 20 years, the use of ultrasound in pregnancy has dramatically increased the numbers of ovarian cysts diagnosed.
The majority of these ovarian cysts in pregnancy either resolve spontaneously or are due to benign conditions.
Ovarian cancer is extremely rare in women of childbearing age and thus most of these cysts can be managed conservatively.
In terms of malignancy potential, those that are malignant are likely to be borderline.
Unless there is a suspicion of malignancy or there is a significant cyst complication, such as torsion, surgery is not indicated.
MRI is a safe and useful tool to help evaluate cysts in more detail in situations where ultrasound provides an inconclusive answer.
If surgery is planned, this should take place during the second trimester to minimise the risk of miscarriage.
Whether surgery is done laparoscopically or using a traditional open approach, it is largely dependent on operator experience and patient preference.
Aspiration of ovarian cysts is only indicated where they appear simple on ultrasound and where they are causing pain or are thought to be obstructing the birth canal.
If surgery does not take place, then ultrasound follow-up during and after pregnancy may be advised accordingly.
NHSCSP cervical screening program and treatment of CIN and CGINWai Phyo
To understand referral pathway for Colposcopy and treatment of precancerous lesion of cervical cancer. To provide facts that would be benefit for MRCOG exam.
Oncology Nursing:-An oncology nurse is a specialized nurse who cares for cancer patients. These nurses require advanced certifications and clinical experiences in oncology further than the typical baccalaureate nursing program provides. Oncology nursing care can be defined as meeting the various needs of oncology patients during the time of their disease including appropriate screenings and other preventive practices, symptom management, care to retain as much normal functioning as possible, and supportive measures upon the end of life.
What is oncology?
Oncology is the branch of medicine that researches, identifies, and treats cancer. A physician who works in the field of oncology is an oncologist.
Oncologists must first diagnose cancer, which is usually carried out via biopsy, endoscopy, X-ray, CT scanning, MRI, PET scanning, ultrasound, or other radiological methods. Nuclear medicine can also be used to diagnose cancer, as can blood tests or tumor markers. Oncology is often linked with hematology, which is the branch of medicine that deals with blood and blood-related disorders.
Treatment
Once a diagnosis is made, the oncologist discusses the disease stage with the patient. Staging will dictate the treatment of cancer. Chemotherapy — which is defined as the destruction of cancer cells — may be used, as well as radiation therapy. Surgery is used to remove tumors. Hormone therapy is used to treat certain types of cancers, and monoclonal antibody treatments are gaining popularity. Research into cancer vaccines and immunotherapies is ongoing. Palliative care in oncology treats pain and other symptoms of cancer.
Treatment team
Cancer is often treated in a team effort, with at least two or three types of oncologists, including medical, surgical, or radiation. The oncology treatment team may also include a pathologist, a diagnostic radiologist, or an oncology nurse. In the event of a new or a difficult-to-treat case of cancer, the oncology care team may consult a tumor board, made up of various medical experts from all relevant disciplines. The tumor board reviews the case and recommends the best course of cancer treatment for the patient.
Oncology nurse
The oncology nurse has many roles, from helping with cancer screening, detection, and prevention, to the intensive care focus of bone marrow transplantation. Work settings for oncology nurses also vary and include acute care hospitals, ambulatory care clinics, private offices, radiation therapy facilities, and home care agencies. Oncology nurses work with adult and pediatric patients with cancer.
Pediatric Oncology
Pediatric oncology is a medical specialty that focuses on cancer care for children.
The National Cancer Institute estimates that 10,270 new cases of cancer will be diagnosed in children in 2017. Of these, 1,190 children will die from the disease.
Pediatric oncology is an important medical field that treats all pediatric cancer types, including acute lymphocytic leukemia,
Is there a role for ovarian cancer screeningMing Cheng
Ovarian cancer is the second most common cancer in the female genital tract. Most of the cases are detected late and thus their survival rate is low. This presentation will tell you on the role of ovarian cancer screening based on the current available evidence.
DERIVATION OF MODIFIED BERNOULLI EQUATION WITH VISCOUS EFFECTS AND TERMINAL V...Wasswaderrick3
In this book, we use conservation of energy techniques on a fluid element to derive the Modified Bernoulli equation of flow with viscous or friction effects. We derive the general equation of flow/ velocity and then from this we derive the Pouiselle flow equation, the transition flow equation and the turbulent flow equation. In the situations where there are no viscous effects , the equation reduces to the Bernoulli equation. From experimental results, we are able to include other terms in the Bernoulli equation. We also look at cases where pressure gradients exist. We use the Modified Bernoulli equation to derive equations of flow rate for pipes of different cross sectional areas connected together. We also extend our techniques of energy conservation to a sphere falling in a viscous medium under the effect of gravity. We demonstrate Stokes equation of terminal velocity and turbulent flow equation. We look at a way of calculating the time taken for a body to fall in a viscous medium. We also look at the general equation of terminal velocity.
Salas, V. (2024) "John of St. Thomas (Poinsot) on the Science of Sacred Theol...Studia Poinsotiana
I Introduction
II Subalternation and Theology
III Theology and Dogmatic Declarations
IV The Mixed Principles of Theology
V Virtual Revelation: The Unity of Theology
VI Theology as a Natural Science
VII Theology’s Certitude
VIII Conclusion
Notes
Bibliography
All the contents are fully attributable to the author, Doctor Victor Salas. Should you wish to get this text republished, get in touch with the author or the editorial committee of the Studia Poinsotiana. Insofar as possible, we will be happy to broker your contact.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Phenomics assisted breeding in crop improvementIshaGoswami9
As the population is increasing and will reach about 9 billion upto 2050. Also due to climate change, it is difficult to meet the food requirement of such a large population. Facing the challenges presented by resource shortages, climate
change, and increasing global population, crop yield and quality need to be improved in a sustainable way over the coming decades. Genetic improvement by breeding is the best way to increase crop productivity. With the rapid progression of functional
genomics, an increasing number of crop genomes have been sequenced and dozens of genes influencing key agronomic traits have been identified. However, current genome sequence information has not been adequately exploited for understanding
the complex characteristics of multiple gene, owing to a lack of crop phenotypic data. Efficient, automatic, and accurate technologies and platforms that can capture phenotypic data that can
be linked to genomics information for crop improvement at all growth stages have become as important as genotyping. Thus,
high-throughput phenotyping has become the major bottleneck restricting crop breeding. Plant phenomics has been defined as the high-throughput, accurate acquisition and analysis of multi-dimensional phenotypes
during crop growing stages at the organism level, including the cell, tissue, organ, individual plant, plot, and field levels. With the rapid development of novel sensors, imaging technology,
and analysis methods, numerous infrastructure platforms have been developed for phenotyping.
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...University of Maribor
Slides from talk:
Aleš Zamuda: Remote Sensing and Computational, Evolutionary, Supercomputing, and Intelligent Systems.
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Inter-Society Networking Panel GRSS/MTT-S/CIS Panel Session: Promoting Connection and Cooperation
https://www.etran.rs/2024/en/home-english/
The ability to recreate computational results with minimal effort and actionable metrics provides a solid foundation for scientific research and software development. When people can replicate an analysis at the touch of a button using open-source software, open data, and methods to assess and compare proposals, it significantly eases verification of results, engagement with a diverse range of contributors, and progress. However, we have yet to fully achieve this; there are still many sociotechnical frictions.
Inspired by David Donoho's vision, this talk aims to revisit the three crucial pillars of frictionless reproducibility (data sharing, code sharing, and competitive challenges) with the perspective of deep software variability.
Our observation is that multiple layers — hardware, operating systems, third-party libraries, software versions, input data, compile-time options, and parameters — are subject to variability that exacerbates frictions but is also essential for achieving robust, generalizable results and fostering innovation. I will first review the literature, providing evidence of how the complex variability interactions across these layers affect qualitative and quantitative software properties, thereby complicating the reproduction and replication of scientific studies in various fields.
I will then present some software engineering and AI techniques that can support the strategic exploration of variability spaces. These include the use of abstractions and models (e.g., feature models), sampling strategies (e.g., uniform, random), cost-effective measurements (e.g., incremental build of software configurations), and dimensionality reduction methods (e.g., transfer learning, feature selection, software debloating).
I will finally argue that deep variability is both the problem and solution of frictionless reproducibility, calling the software science community to develop new methods and tools to manage variability and foster reproducibility in software systems.
Exposé invité Journées Nationales du GDR GPL 2024
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
2. Evolution of terminology
Progress evolves from clear understanding of
existing research and experience and clarity of
terminology is fundamental to this
It is not possible to compare apples with oranges
or to understand precisely published evidence
where terminology is unclear
cone biopsy (UK) with cone biopsy (US),
Height
Depth
atypia
3. Practice variation in OB/GYN
C Section, 3rd stage of labour
Antenatal V/E
Hysteroscopy
Management of Endometrial Cancer
Colposcopy
4. Evolution of colposcopy
First colposcope :: Hamburg
Early colposcopic skills
image recognition,
diagnosis of HSIL,
recognition of microinvasion
Late colposcopic skills =
discriminating between normal and
abnormal
facilitating precise treatment
5. MODERN COLPOSCOPY
Objective and easily achieved
skills through structured training as
part of a QA service
Risk assessment using biomarkers
and patient characteristics
Modified treatment techniques
6. Variation in colposcopy and
treatment
Colposcopy is not a defined entity and performs
differently in different settings
Treatment is not a defined entity and produces
different results and complications in different
settings
Nomenclature varies in interpretation and we
therefore can not easily compare practice
7. Colposcopy is not a defined entity
and performs differently in
different settings
Colposcopy performed by variably
trained colposcopists who do not
adhere to strict quality assured
practice or self audit is completely
different to colposcopy in a region
where QA, adherence to best
evidence guidelines and CME are
the norm’
8. Why is there such a difference in
colposcopic reward
ALTS 11.5% CIN 2+ after a normal colposcopy
72.3% of CIN2+ found at original colposcopy
UK NHS study 5.3% CIN2+ after a normal colposcopy
94.6% of CIN2+ found at original colposcopy
9. Why is there such a difference in
colposcopic reward
In the UK NHS CSP colposcopy setting the risk of
missing high grade disease appears to be much lo
than in the equivalent US setting
Why is this?
10. Why is there such a difference in
colposcopic reward
In the UK there exists
A comprehensive training programme
Preceptor based
Strict number of cases under supervision
and subsequently unsupervised
Ongoing assessment during training
Exit exam (OSCE)
30% failure rate
11. Why is there such a difference in
colposcopic reward
In the UK
Colposcopy practice
Devoted colposcopy clinics
All women referred with a suspected
abnormality
Rate of CIN relatively high
Not rewarded according to
procedures performed
Comprehensive audit of practice
12. Treatment is not a defined entity
and produces different results and
complications in different settings
The resection of a small type 1 TZ is easy and
associated with minimal morbidity
The resection of a large Type 3 TZ is difficult
and associated with significant short and
long term morbidity
15. Excision dimensions and preterm labour
Khalid S, Dimitriou E & Prendiville W2009
1999 - 2002
Obstetric &Colpo
databases
353 pregnancies in
women after LLETZ
16. Excision dimensions and preterm labour
Khalid S, Dimitriou E & Prendiville W2009
Increased risk of
preterm labour if
specimens larger
than 6 cubic cms
RR 3.17, 95%CI 1.56 -
6.38
17. Excision dimensions and preterm labour
Khalid S, Dimitriou E & Prendiville W2009
Increased risk of
preterm labour if
specimens thicker
than 12 mms
RR 3.05, 95%CI 1.37 -
7.08
18. 2011 IFCPC colposcopic terminology of the cervix(draft – May 2011)
SCJ visualization: complete/partial/none
Adequate/inadequate for the reason … (i.e.: cervix
obscured by inflammation, bleeding, scar)
Basic definitions
Deciduosis in
pregnancy,
Atrophic epithelium,
Nabothian cyst,
Gland (crypt)
openings
Original squamous epithelium,
Columnar epithelium
including ectopy,
Transformation zone types 1,2,3
Normal colposcopic
findings
Inside or outside the T-zone,
Numberof cervical quadrantsthe l esioncovers ,
Size of the lesion in percentage of cervix,
Lugol’s staining (Schiller’s test): stained/non-stained
General
principles
Abnormal
colposcopic
findings
Fine mosaic,
Fine punctation
Fine aceto-white epitheliumGrade 1
(Minor)
Rapid appearance of
acetowhitening,
Cuffed gland (crypt)
openings
Sharp border,
Exophytic
lesion,
Inner border
sign,
Ridge sign
Dense aceto-
white
epithelium,
Coarse mosaic,
Coarse
punctuation,
Leukoplakia
Grade 2
(Major)
Atypical vessels, fragile vessels, Irregular surface,
Necrosis, Ulceration (necrotic), tumor/gross neoplasm
Suspicious for invasion
Stenosis,
Congenital anomaly,
Post treatment
consequence
Endometriosis,
Condyloma,
Polyp
(Ectocervical/
endocervical)
Erosion
(traumatic)
Inflammation
Miscellaneous finding
19. Nomenclature committee 2011
Jim Bentley - Canada
Jacob Bornstein – Israel (Chairman of the
Committee)
Peter Bosze – Hungary
Frank Girardi – Austria
Hope Haefner - USA
Michael Menton – Germany
MyriamPerrota – Argentina
Walter Prendiville – Ireland
Peter Russell - Australia
Mario Sideri – Italy
27. Colposcopic features suggestive of
highgrade disease (major change)
A generally smooth surface with an sharp outer border.
Dense acetowhite change, that appears early and is slow to resolve; it may
appear oyster white.
Iodine negativity, a yellow appearance in a previously densely white
epithelium.
Coarse punctation and wide irregular mosaics of differing size.
Dense acetowhite change within columnar epithelium may indicate
glandular disease.
28. New S C Junction
Columnar
Original
squamous epithelium
Crypt openings
35. Size of cervical lesions
Kierkegaard 1995: lesion size has independent
predictive value
Ferris 2005: Size of cervical lesions correlates directly with
the severity of disease.
Hopman et al. 1995 reported an inter-observer
agreement rate of 68% when evaluating colposcopic
photographs for lesion size.
Hammes 2007: Lesions >50% of cervix had higher
probability for high-grade lesion / carcinoma (OR, 3.45).
Prof Jacob Bornstein
36.
37.
38. New colposcopic sign- Ridge sign
An opaque acetowhite ridge
at the squamocolumnar junction
Prof Jacob Bornstein
Scheungraber C, Koenig U, Fechtel B, Kuehne-Heid R, Duerst M, Schneider A. The colposcopic feature ridge sign is associated with the
presence of cervical intraepithelial neoplasia 2/3 and human papillomavirus 16 in young women. J Low Genit Tract Dis. 2009;13(1):13-
16.
39. A New Scoring System
Strander et al 2005
Designed to evaluate a scoring system for high
grade lesions
297 examinations of women referred for
colposcopy, Department of Obstetrics and
Gynecology, Göteborg, Sweden
First Scoring system to incorporate lesion size as a
variable
Subsequently validated at the Royal Free
41. 0 1 2 Score
ACETO UPTAKE Zero or transparent Shady, Milky
(not transparent
not opaque)
Distinct, opaque
white
MARGINS/
SURFACE
Diffuse Sharp but
irregular, jagged,
“geographical”
Satellites
Sharp and even,
difference in
surface level incl
“cuffing”
VESSELS Fine, regular Absent Coarse or atypical
LESION SIZE <5mm 5-15mm or 2
quadrants
>15mm or 3-4
quadrants or
endocervically
undefined
IODINE STAINING Brown Faintly or patchy
yellow
Distinct yellow
Total score 10
42. The transformation zone
A Type 1 transformation zone is completely
ectocervical and fully visible, and may be small
or large
A Type 2 transformation zone has an
endocervical component, is fully visible, and
may have an ectocervical component that may
be small or large
A Type 3 transformation zone has an
endocervical component that is not fully visible
and may have an ectocervical component that
may be small or large
44. SBX1739_3
Histology CIN1
Cytology LSIL,CIN 1;Atyp
endocerv,
neopl
Carcinogenic
HPV
16, 58, 66
Age 28
Category Mario Walter
SCJ visibility Fully Visible Fully Visible
TZ type Type 1 - Small Type 1 - Small
TZ pattern Abnormal Grade 1 Abnormal Grade 2
Image quality Good Good
Jim Usha
Partially Visible Partially Visible
Type 2 - Large Type 1 - Large
Abnormal Grade 2 Normal
Good Limited
45. SBX1759_3
Histology CIN3
Cytology LSIL,CIN 1;Atyp
endocerv,
neopl
Carcinogenic
HPV
16, 51
Age 25
Category Mario Walter
SCJ visibility Partially Visible Fully Visible
TZ type Type 2 - Small Type 1 - Small
TZ pattern Abnormal Grade 2 Abnormal Grade 1
Image quality Good Limited
Jim Usha
Fully Visible Fully Visible
Type 1 - Small Type 1 - Small
Abnormal Grade 1 Normal
Good Good
48. SBX1842_1
Histology CIN3
Cytology HSIL,CIN
3;Adeno, NOS
Carcinogenic
HPV
16, 18
Age 30
Category Mario Walter
SCJ visibility Partially Visible Partially Visible
TZ type Type 3 - Small Type 2 - Small
TZ pattern Abnormal Grade 2 Suspicious for invasion
Image quality Limited Limited
Jim Usha
Fully Visible Fully Visible
Type 2 - Small Type 1 - Small
Abnormal Grade 2 Abnormal Grade 2
Good Limited
51. SBX1216_2
Histology CIN3
Cytology HSIL,CIN 2;Adeno
in situ (AIS)
Carcinogenic HPV 31
Age 21
Category Mario Walter
SCJ visibility Not Visible Partially Visible
TZ type Type 3 - Small Type 2 - Small
TZ pattern Abnormal Grade 1 Abnormal Grade 2
Image quality Good Good
Jim Usha
Not Visible Fully Visible
Type 3 - Small Type 1 - Large
Abnormal Grade 2 Abnormal Grade 1
Good Good
52. SBX1774_1
Histology CIN3
Cytology HSIL,CIN
3;Adeno, NOS
Carcinogenic
HPV
16
Age 47
Category Mario Walter
SCJ visibility Not Visible Partially Visible
TZ type Type 3 - Small Type 2 - Small
TZ pattern Abnormal Grade 2 Suspicious for invasion
Image quality Good Good
Jim Usha
Not Visible Not Visible
Type 3 - Small Type 3 - Large
Suspicious for invasion Suspicious for invasion
Good Good
53. SBX1928_1
Histology CIN3
Cytology HSIL,CIN
3;Adeno, NOS
Carcinogenic
HPV
16, 39
Age 30
Category Mario Walter
SCJ visibility Not Visible Not Visible
TZ type Type 3 - Small Type 3 - Small
TZ pattern Abnormal Grade 2 Abnormal Grade 2
Image quality Good Good
Jim Usha
Partially Visible Fully Visible
Type 3 - Small Type 1 - Small
Abnormal Grade 1 Abnormal Grade 1
Good Good
54.
55.
56.
57.
58. The BSCCP invites
you to the
15th World
Congress
On behalf of
IFCPC
In London
26-30th May 2014
www.IFCPC2014.
63. National Institute of Medical Research- The biology of HPV and molecular markers
Wolfson Institute of Preventive of Medicine- Screening across the world
St Thomas’s Hospital – Improving Cytology
Institute of Women’s Health
Imperial College
Post Congress Seminars
