1. The document describes two cases of peripheral vertigo seen by Dr. Sanjay Maharjan.
2. The first case involves a 51-year-old man experiencing right-sided vertigo, nausea, and vomiting for one week. Examination revealed right-sided benign paroxysmal positional vertigo (BPPV), which was treated successfully with Epley maneuver.
3. The second case involves a 45-year-old man with fever, runny nose, dizziness, and nausea/vomiting for several days. Examination found horizontal nystagmus, and he was diagnosed provisionally with vestibular neuritis. He was admitted and treated with medications, showing improvement after
UG CASE PRESENTATION ON INGUINAL HERNIAAyesha Huma
I have added viva notes after this proforma for quick revision of important stuff asked in exam.
LINK FOR EXAMINATION VIDOES :
1. https://youtu.be/uO-w_9w5okI
2. https://youtu.be/Vc_ZH_-Oad4
UG CASE PRESENTATION ON INGUINAL HERNIAAyesha Huma
I have added viva notes after this proforma for quick revision of important stuff asked in exam.
LINK FOR EXAMINATION VIDOES :
1. https://youtu.be/uO-w_9w5okI
2. https://youtu.be/Vc_ZH_-Oad4
Comment by Morgan, Dorothy Tali Do not forget to include a runniLynellBull52
Comment by Morgan, Dorothy Tali: Do not forget to include a running head to follow APA guidelines
Health History
Yensi Aguilar
Benjamin Leon School of nursing
NUR1060C: Adult Health Assessment
Professor Dorothy Morgan
April 7, 2021
Health History
Identifying data
Date of history: 28/02/2021
Examiner: Yensi Aguilar
Name: L.P.
Address: 3403 SW 6h Street
Phone Number: 786-597-3071
Age:46
Sex: Female
Race: White
Place of Birth: Honduras
Marital Status: Married
Significant Other: Husband
Occupation: Teacher
Religion: Christian
Primary Language: Spanish
Secondary Language: English
Source of referral: The patient found the hospital’s address on the internet
Source of history: Documents with the patient’s health history gave information concerning the patient. The patient also talked concerning her health status.
Reliability: Currently, the patient seems to have a stable mental and physical state.
Chief Complaints/Reasons for Visit: According to the patient, she started experiencing high fever, blood-stained sputum, night sweats, coughing, and weight loss.
Present Illness
Time of onset: according to the patient, she started experiencing symptoms two weeks ago.
Type of onset: The patient says that she started by occasionally sweating, mild cough, headache, and pain in the abdomen area. Over time, these conditions became severe.
Original Source: The patient complains of pain in her chest and respiratory tract.
Severity: During the day, the patient does not feel many discomforts, but it becomes worse at night due to lower temperatures. Hence, the condition does not deter the patient from executing tasks during the day. The severity of her state is at 5 out of 10 on a 0-to-10-point scale.
Radiation: At night, the patient feels severe pain throughout her chest region
Time Relationship: At first, this condition was still developing and was easy to handle. However, it has evolved and has gotten worse.
Duration: It has been two weeks since the patient started experiencing the symptoms.
Association: The symptoms experienced by the patient are similar to those of flu.
Source of Relief: According to the patient, she feels better when resting after doing some light physical exercise.
Source of Aggravation: The symptoms become worse during the night. Again, exposure to allergens such as dust or cold increases the symptom’s severity.
Past History
General State of Health: The patient’s general condition is fair, considering she is suffering from a chronic illness.
Childhood Illnesses: She suffered from smallpox and measles as a child
Adult Illnesses: Hypertension, Anemia, and asthma
Psychiatric Illnesses: She has experienced mild depression in the past
Accidents and Injuries: Never had an accident or injuries
Operations: The patient denies any surgical operations
Hospitalizations: After visiting the hospital, the patient got an admission to the Jackson Hospital for one week to undergo treatment for asthma and hyper ...
DISSERTATION on NEW DRUG DISCOVERY AND DEVELOPMENT STAGES OF DRUG DISCOVERYNEHA GUPTA
The process of drug discovery and development is a complex and multi-step endeavor aimed at bringing new pharmaceutical drugs to market. It begins with identifying and validating a biological target, such as a protein, gene, or RNA, that is associated with a disease. This step involves understanding the target's role in the disease and confirming that modulating it can have therapeutic effects. The next stage, hit identification, employs high-throughput screening (HTS) and other methods to find compounds that interact with the target. Computational techniques may also be used to identify potential hits from large compound libraries.
Following hit identification, the hits are optimized to improve their efficacy, selectivity, and pharmacokinetic properties, resulting in lead compounds. These leads undergo further refinement to enhance their potency, reduce toxicity, and improve drug-like characteristics, creating drug candidates suitable for preclinical testing. In the preclinical development phase, drug candidates are tested in vitro (in cell cultures) and in vivo (in animal models) to evaluate their safety, efficacy, pharmacokinetics, and pharmacodynamics. Toxicology studies are conducted to assess potential risks.
Before clinical trials can begin, an Investigational New Drug (IND) application must be submitted to regulatory authorities. This application includes data from preclinical studies and plans for clinical trials. Clinical development involves human trials in three phases: Phase I tests the drug's safety and dosage in a small group of healthy volunteers, Phase II assesses the drug's efficacy and side effects in a larger group of patients with the target disease, and Phase III confirms the drug's efficacy and monitors adverse reactions in a large population, often compared to existing treatments.
After successful clinical trials, a New Drug Application (NDA) is submitted to regulatory authorities for approval, including all data from preclinical and clinical studies, as well as proposed labeling and manufacturing information. Regulatory authorities then review the NDA to ensure the drug is safe, effective, and of high quality, potentially requiring additional studies. Finally, after a drug is approved and marketed, it undergoes post-marketing surveillance, which includes continuous monitoring for long-term safety and effectiveness, pharmacovigilance, and reporting of any adverse effects.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
5. HISTORY OF PRESENT ILLNESS:
• Dizziness:
• Started at night at around 3:00 AM
• True Rotatory sensation
• Intermittent
• Lasts < 1 min
• Aggravated when looking up, looking down
and especially looking to Right
• Relieved while sleeping without moving his
head
6. Also c/o constant woozy/drunk feeling worse
when looking down
Nausea and vomitting:
Associated with dizziness
Severe episodes of nausea
Vomitting 3-4 times
7. • No history of:
• LOC or weakness
• Gait deviations
• Pain around neck or difficulty moving
head
• Ear discharge or ear ache
• Aural fullness or Hearing loss
• Tinnitus
• Recent attacks of URTI
• Visual complaints
8. With these complains pt was taken to a local
hospital where few pints of IVF and antiemetic
was given
Symptoms did not subside
Brought to emergency dept of Manipal
9. PAST HISTORY:
Similar episode but of lesser severity that
relieved after taking some OTC drugs
(undocumented)
No DM, HTN, TB or COPD
No history of ear surgery or other major
surgeries
10. DRUG HISTORY:
No h/o taking any drug regularly
Not known to be allergic to any drugs
11. PERSONAL HISTORY:
Appetite: Decreased
Diet: Mixed
Bowel and bladder : Regular
Sleep: Decreased
Habits – Smoker, non alcoholic
12. FAMILY HISTORY:
No similar complains
SOCIO-ECONOMIC HISTORY:
Middle class
Shopkeeper
13. GENERAL EXAMINATION:
GC : Anxious, irritable
BP : 110/80 mmHg
Temp : 98.5 F
RR : 22/min
Pulse : 89b/min
15. LOCAL EXAMINATION:
Ear:
Pre-auricular, pinna and post-auricular
region of b/l ear : normal
EAC : No discharge in b/l ear
TM : No perforation in b/l ear
Facial nerve : Intact in both sides
16. Tuning fork test:
Rinne’s test : positive B/L
Weber’s test : Central
Spontaneous nystagmus : absent
Pure Tone Audiometry:
WNL
17. Subjective tests :
Fistula test : -ve
Rhomberg’s test : +ve, falls in R side
Dix Hallpike maneuver :
R: +ve severe vertigo & downbeating R
torsional nystagmus, latency 2-3 sec, lasted <
1 min
L: Normal
19. TREATMENT:
Epley Maneuver for R ear
Repeated 3 times
less vertigo / nystagmus during each repeat
Post-Epley instructions :
For 48 hrs,
Avoid sleeping on involved side
Avoid forceful head movements
20. Pt discharged with following medications :
Tab. Prochloperazine 25mg PO TDS 7D
Tab. Betahistine 16mg PO TDS 2Wks
Tab. Ondansetron 4mg PO SOS
Follow up after 1 Wk
21. RE-EVALUATION : 2ND VISIT
No more vertigo since initial treatment
Occasional “woozy” feeling when looking
down, but very mild
Dix Hallpike –ve B/l
24. CHIEF COMPLAINTS :
Fever and runny nose for 5 days
Dizziness for 2 days
Nausea vomitting for 2 days
25. HISTORY OF PRESENT
ILLNESS:
Fever:
Intermittent
Max recorded 100F
Not as/w chills and rigor
As/w watery nasal discharge & throat pain
Relieving after taking some OTC drugs
(undocumented) ?gargle ?antihistamine
26. Dizziness:
Rotatory sensation
Sudden onset
Continuous but gradually decreasing in
severity
Aggravated on head movement but not on
specific head position
No relieving factor
27. Nausea and vomitting:
Associated with dizziness
Severe episodes of nausea
Vomiting multiple episodes
28. No history of:
LOC or weakness
Gait deviations
Pain around neck or difficulty moving
head
Aggravation on certain head position
Ear discharge or ear ache
Aural fullness or Hearing loss
Tinnitus
29. With these complaints brought to emergency room
of Manipal Teaching Hospital
30. PAST HISTORY:
h/o recurrent attacks of URTI
k/c/o HTN under medication
No DM, TB or COPD
No history of ear surgery or other major
surgeries
31. DRUG HISTORY:
h/o taking OTC drugs (undocumented) for
fever and throat pain 5 days back
No other regular use of any drugs
Not known to be allergic to any drugs
33. LOCAL EXAMINATION:
Ear:
Pre-auricular, pinna and post-auricular
region of b/l ear : normal
EAC : No discharge in b/l ear
TM : No perforation in b/l ear
Facial nerve : Intact in both sides
34. Tuning fork test:
Rinne’s test : Positive B/l
Weber’s test : Central
Nystagmus :
Present spontaneously
Horizontal, fast beating to left side
Grade III
Supressed on looking at the mark
36. TREATMENT:
Pt was admitted in ENT ward with following
medications:
Tab. Betahistine 16mg PO TDS
Tab. Cinnarazine 25mg PO TDS
Inj. Hydrocort 100mg IV TDS
Inj. Pantoprazole 40mg IV OD
Inj. Ondansetron 8mg IV TDS
Inj Phenargan 50mg IM SOS
37. PROGRESS REPORT:
Pt was symptomatically well following 3 days of
admission
Nystagmus reduced to Grade I
PTA done, was normal
c/o minimal vertigo with sudden movement of
head
Discharged on 3rd DOA with oral medications