This document provides an overview of carboxylic acid derivatives including esters, amides, nitriles, acid halides, anhydrides, and lactones/lactams. It discusses their structures, naming conventions, physical properties such as boiling points and solubility, and spectral data from techniques like IR, 1H NMR, and 13C NMR spectroscopy. Key characteristics and reactions of each derivative type are summarized.
Aldehydes and ketones are the carbonyl compounds with general formula CnH2nO. Aldehydes have at least one hydrogen atom bonded to the carbonyl group and other group is either hydrogen or an alkyl or aryl group (i.e. Aldehyde has one alkyl or aryl group and one of the hydrogen bonded to the carbonyl carbon) with characteristics functional group -CHO.
Aldehydes and ketones are the carbonyl compounds with general formula CnH2nO. Aldehydes have at least one hydrogen atom bonded to the carbonyl group and other group is either hydrogen or an alkyl or aryl group (i.e. Aldehyde has one alkyl or aryl group and one of the hydrogen bonded to the carbonyl carbon) with characteristics functional group -CHO.
Synthetic reagent and applications OF ALUMINIUM ISOPROPOXIDEShikha Popali
SYNTHETIC REAGENTS AND APPLICATIONS OF ALUMINIUM ISOPROPOXIDE ITS ALTERNATIVE NAMES AND ITS PHYSICAL PROPERTIRS , HANDLING, STORAGE, PRECAUTIONS, PREPARATIONS, SYNTHETIC APPLICATIONS
This is Power Point Presentation on Topic "Electrophilic Aromatic Substitution Reactions" as per syllabus of "University of Mumbai" for S.Y. B. Pharmacy (Sem.: IV) students.
Presented by Dhanashree Kavhale. M. Pharm.(Pharmaceutical Chemistry) 1st year.
Various organic named reactions are there in Advanced Organic Chemistry I, as some of them are explained along with their mechanism.
Synthetic reagent and applications OF ALUMINIUM ISOPROPOXIDEShikha Popali
SYNTHETIC REAGENTS AND APPLICATIONS OF ALUMINIUM ISOPROPOXIDE ITS ALTERNATIVE NAMES AND ITS PHYSICAL PROPERTIRS , HANDLING, STORAGE, PRECAUTIONS, PREPARATIONS, SYNTHETIC APPLICATIONS
This is Power Point Presentation on Topic "Electrophilic Aromatic Substitution Reactions" as per syllabus of "University of Mumbai" for S.Y. B. Pharmacy (Sem.: IV) students.
Presented by Dhanashree Kavhale. M. Pharm.(Pharmaceutical Chemistry) 1st year.
Various organic named reactions are there in Advanced Organic Chemistry I, as some of them are explained along with their mechanism.
BREEDING METHODS FOR DISEASE RESISTANCE.pptxRASHMI M G
Plant breeding for disease resistance is a strategy to reduce crop losses caused by disease. Plants have an innate immune system that allows them to recognize pathogens and provide resistance. However, breeding for long-lasting resistance often involves combining multiple resistance genes
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Phenomics assisted breeding in crop improvementIshaGoswami9
As the population is increasing and will reach about 9 billion upto 2050. Also due to climate change, it is difficult to meet the food requirement of such a large population. Facing the challenges presented by resource shortages, climate
change, and increasing global population, crop yield and quality need to be improved in a sustainable way over the coming decades. Genetic improvement by breeding is the best way to increase crop productivity. With the rapid progression of functional
genomics, an increasing number of crop genomes have been sequenced and dozens of genes influencing key agronomic traits have been identified. However, current genome sequence information has not been adequately exploited for understanding
the complex characteristics of multiple gene, owing to a lack of crop phenotypic data. Efficient, automatic, and accurate technologies and platforms that can capture phenotypic data that can
be linked to genomics information for crop improvement at all growth stages have become as important as genotyping. Thus,
high-throughput phenotyping has become the major bottleneck restricting crop breeding. Plant phenomics has been defined as the high-throughput, accurate acquisition and analysis of multi-dimensional phenotypes
during crop growing stages at the organism level, including the cell, tissue, organ, individual plant, plot, and field levels. With the rapid development of novel sensors, imaging technology,
and analysis methods, numerous infrastructure platforms have been developed for phenotyping.
The ability to recreate computational results with minimal effort and actionable metrics provides a solid foundation for scientific research and software development. When people can replicate an analysis at the touch of a button using open-source software, open data, and methods to assess and compare proposals, it significantly eases verification of results, engagement with a diverse range of contributors, and progress. However, we have yet to fully achieve this; there are still many sociotechnical frictions.
Inspired by David Donoho's vision, this talk aims to revisit the three crucial pillars of frictionless reproducibility (data sharing, code sharing, and competitive challenges) with the perspective of deep software variability.
Our observation is that multiple layers — hardware, operating systems, third-party libraries, software versions, input data, compile-time options, and parameters — are subject to variability that exacerbates frictions but is also essential for achieving robust, generalizable results and fostering innovation. I will first review the literature, providing evidence of how the complex variability interactions across these layers affect qualitative and quantitative software properties, thereby complicating the reproduction and replication of scientific studies in various fields.
I will then present some software engineering and AI techniques that can support the strategic exploration of variability spaces. These include the use of abstractions and models (e.g., feature models), sampling strategies (e.g., uniform, random), cost-effective measurements (e.g., incremental build of software configurations), and dimensionality reduction methods (e.g., transfer learning, feature selection, software debloating).
I will finally argue that deep variability is both the problem and solution of frictionless reproducibility, calling the software science community to develop new methods and tools to manage variability and foster reproducibility in software systems.
Exposé invité Journées Nationales du GDR GPL 2024
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
2. Chapter 21 2
Acid Derivatives
All the derivatives can be converted to the
carboxylic acid by acidic or basic hydrolysis.
Esters and amides are commonly found in
nature.
3. Chapter 21 3
Esters from Carboxylic Acids
Esters can be made from the carboxylic acid
through the Fischer esterification.
Excess alcohol is used to drive the equilibrium
toward the ester.
4. Chapter 21 4
Nomenclature of Esters
Esters are named as alkyl carboxylates.
The first word is derived from the alkyl group
of the alcohol, and the second word from the
carboxylate group of the carboxylic acid.
5. Chapter 21 5
Cyclic Esters
Reaction of —OH and —COOH on same molecule
produces a cyclic ester called lactone.
To name, add the word lactone to the IUPAC acid
name or replace the -ic acid of common name with
-olactone.
6. Chapter 21 6
Amide Structure
Amides are the product of the reaction of a carboxylic
acid with ammonia or an amine.
Not basic because the lone pair on nitrogen is
delocalized by resonance.
The C—N bond has double-bond character.
7. Chapter 21 7
Protonation of Amides
Under acidic conditions, the double-bonded
oxygen will get protonated.
8. Chapter 21 8
Classes of Amides
1° amide has one C—N bond (two N—H).
2° amide or N-substituted amide has two C—N bonds
(one N—H).
3° amide or N,N-disubstituted amide has three C—N
bonds (no N—H).
3º amide 2º amide 1º amide
9. Chapter 21 9
Nomenclature of Amides
For 1° amide, drop -ic or -oic acid from the
carboxylic acid name, add -amide.
Alkyl groups bonded to nitrogen are named
with N-alkyl to indicate their attachment to the
nitrogen atom.
N-ethyl-N-methyl-2-dimethylpropanamide
(N-ethyl-N-methylisobutyramide)CH3CHC N
O
CH2CH3
CH3
CH3
10. Chapter 21 10
Cyclic Amides
Cyclic amides are called lactams.
To name, add the word lactam to the IUPAC
acid name or replace the -ic acid of common
name with -olactam.
11. Chapter 21 11
Nitriles
Nitriles contain the cyano group (—C≡N).
They can be hydrolyzed to carboxylic acids.
12. Chapter 21 12
Structures of Acetonitrile and
Propyne
In both compounds, the atoms at the ends of the triple bonds
are sp hybridized, and the bond angles are 180°.
In place of the acetylenic hydrogen atom, the nitrile has a lone
pair of electrons in the sp orbital of nitrogen.
The nonbonding electrons on the nitrogen are not basic.
13. Chapter 21 13
Naming Nitriles
For IUPAC names, add -nitrile to the alkane name.
The Ethyl Octanoate group can also be named as a
substituent, the cyano group.
Common names come from the carboxylic acid.
Replace -ic acid with -onitrile.
CH3 C N
acetonitrile 3-cyanopentanoic acid
CH3 CH2 CH CH2 COOH
CN
CN
cyclopropanecarbonitrile
14. Chapter 21 14
Acid Halides
R C Cl
O
R C Br
O
acid chloride
(acyl chloride)
acid bromide
(acyl bromide)
Also called acyl halides.
These are more reactive than carboxylic acids, so
they are used to synthesize other acid derivatives
such as esters and amides.
Used in the Friedel–Crafts acylation to make
acylbenzenes.
15. Chapter 21 15
Acid Halide Nomenclature
CH3CH2 C Cl
O
CH3CHCH2 C Br
OBr
propanoyl chloride 3-bromobutanoyl bromide
Named by replacing -ic acid with -yl halide.
Acyl chlorides are more common.
16. Chapter 21 16
Acid Anhydrides
Two molecules of acid combine with the loss of water
to form the anhydride.
Anhydrides are more reactive than acids, but less
reactive than acid chlorides.
A carboxylate ion is the leaving group in nucleophilic
acyl substitution reactions.
17. Chapter 21 17
Anhydride Nomenclature
CH3 C O
O
C
O
CH3 CF3 C O
O
C
O
CF3 CH3 C O
O
C
O
H
ethanoic anhydride
(acetic anhydride)
trifluoroethanoic anhydride
(trifluoroacetic anhydride)
ethanoic methanoic anhydride
(acetic formic anhydride)
The word acid is replaced with anhydride.
For a mixed anhydride, name both acids.
18. Chapter 21 18
Multifunctional Compounds
The functional group with the highest priority
determines the parent name.
CH C NCH2CH3
OH
2-hydroxybutanenitrile
acid > ester > amide > nitrile > aldehyde > ketone >
alcohol > amine > alkene > alkyne
21. Chapter 21 21
Melting Points
Amides have very high boiling points and melting
points compared to other compounds of similar
weight.
Melting points increase with increasing number of
N—H bonds.
Tertiary amides cannot hydrogen bond, but still have
high boiling points.
22. Chapter 21 22
Solubility
Acid chlorides and anhydrides are too
reactive to be used with water or alcohol.
Esters, 3° amides, and nitriles are good
polar aprotic solvents.
Solvents commonly used in organic
reactions:
Ethyl acetate
Dimethylformamide (DMF)
Acetonitrile
30. Chapter 21 30
13
C–NMR Spectroscopy
The carbonyl carbons of acid derivatives appear at
shifts around 170 to 180 ppm, slightly more shielded
than the carbonyl carbons of ketones and aldehydes.
The α-carbon atoms absorb around 30 to 40 ppm.
Editor's Notes
Figure: 21_03-02T2.jpg
Title:
Esters, Amides, and Nitriles Commonly Used as Solvents for Organic Reactions
Caption:
Table 21-2 Esters, amides, and nitriles commonly used as solvents for organic reactions.
Notes:
Figure: 21_05.jpg
Title:
IR Frequencies of Lactones and Lactams
Caption:
Ring strain in a lactam increases the carbonyl stretching frequency.
Notes:
High strained systems have higher C=O frequencies.