5th International Disaster and Risk Conference IDRC 2014 Integrative Risk Management - The role of science, technology & practice 24-28 August 2014 in Davos, Switzerland
GENE ENVIRONMENT INTERACTION
Subtle differences in one person’s genes can cause them to respond differently to the same environmental exposure as another person. As a result, some people may develop a disease after being exposed to something in the environment while others may not.
As scientists learn more about the connection between genes and the environment, they pursue new approaches for preventing and treating disease that consider individual genetic codes.
What are the challenges surrounding protecting children from the exposure to pesticides?
Michael J. DiBartolomeis, PhD, DABT, California Department of Public Health presents these findings to Senator Josh Green, M.D., Chair of the Senate Health Committee for Hawaii.
January 20, 2015
Endocrine Disruption and Immune DysfunctionDES Daughter
by the Collaborative on Health and the Environment
On this first in a series of calls on endocrine disrupting chemicals, Dr. Rodney Dietert discussed how the immune system is a target for endocrine disrupting chemicals, particularly during development. Numerous relatively ‘hidden’ effects can ensue from a single risk factor and emerge over a lifetime. He also discussed how current safety testing fails to appropriately assess misregulated inflammation as the greatest immune based health risk.
Sources: http://www.healthandenvironment.org/partnership_calls/13389
To gain more insight about the environmental impact on your risk of developing breast cancer, I strongly suggest you view this presentation. These slides will help you understand the way these pesticides/herbicides and other estrogen mimickers affect your breast tissue. They will also help to explain the “Before & After” images on our website. This is crucial for an understanding of how cancers respond in a metabolic or physiological way.
Child Development & Environmental Toxins - Resources for Healthy Children www.scribd.com/doc/254613619 - For more information, Please see Organic Edible Schoolyards & Gardening with Children www.scribd.com/doc/254613963 - Gardening with Volcanic Rock Dust www.scribd.com/doc/254613846 - Double Food Production from your School Garden with Organic Tech www.scribd.com/doc/254613765 - Free School Gardening Art Posters www.scribd.com/doc/254613694 - Increase Food Production with Companion Planting in your School Garden www.scribd.com/doc/254609890 - Healthy Foods Dramatically Improves Student Academic Success www.scribd.com/doc/254613619 - City Chickens for your Organic School Garden www.scribd.com/doc/254613553 - Huerto Ecológico, Tecnologías Sostenibles, Agricultura Organica www.scribd.com/doc/254613494 - Simple Square Foot Gardening for Schools - Teacher Guide www.scribd.com/doc/254613410 - Free Organic Gardening Publications www.scribd.com/doc/254609890 ~
GENE ENVIRONMENT INTERACTION
Subtle differences in one person’s genes can cause them to respond differently to the same environmental exposure as another person. As a result, some people may develop a disease after being exposed to something in the environment while others may not.
As scientists learn more about the connection between genes and the environment, they pursue new approaches for preventing and treating disease that consider individual genetic codes.
What are the challenges surrounding protecting children from the exposure to pesticides?
Michael J. DiBartolomeis, PhD, DABT, California Department of Public Health presents these findings to Senator Josh Green, M.D., Chair of the Senate Health Committee for Hawaii.
January 20, 2015
Endocrine Disruption and Immune DysfunctionDES Daughter
by the Collaborative on Health and the Environment
On this first in a series of calls on endocrine disrupting chemicals, Dr. Rodney Dietert discussed how the immune system is a target for endocrine disrupting chemicals, particularly during development. Numerous relatively ‘hidden’ effects can ensue from a single risk factor and emerge over a lifetime. He also discussed how current safety testing fails to appropriately assess misregulated inflammation as the greatest immune based health risk.
Sources: http://www.healthandenvironment.org/partnership_calls/13389
To gain more insight about the environmental impact on your risk of developing breast cancer, I strongly suggest you view this presentation. These slides will help you understand the way these pesticides/herbicides and other estrogen mimickers affect your breast tissue. They will also help to explain the “Before & After” images on our website. This is crucial for an understanding of how cancers respond in a metabolic or physiological way.
Child Development & Environmental Toxins - Resources for Healthy Children www.scribd.com/doc/254613619 - For more information, Please see Organic Edible Schoolyards & Gardening with Children www.scribd.com/doc/254613963 - Gardening with Volcanic Rock Dust www.scribd.com/doc/254613846 - Double Food Production from your School Garden with Organic Tech www.scribd.com/doc/254613765 - Free School Gardening Art Posters www.scribd.com/doc/254613694 - Increase Food Production with Companion Planting in your School Garden www.scribd.com/doc/254609890 - Healthy Foods Dramatically Improves Student Academic Success www.scribd.com/doc/254613619 - City Chickens for your Organic School Garden www.scribd.com/doc/254613553 - Huerto Ecológico, Tecnologías Sostenibles, Agricultura Organica www.scribd.com/doc/254613494 - Simple Square Foot Gardening for Schools - Teacher Guide www.scribd.com/doc/254613410 - Free Organic Gardening Publications www.scribd.com/doc/254609890 ~
Impact of Aerosols on Respiratory Health of Dairy Workers and Residents Livin...LPE Learning Center
The full proceedings paper is at: http://www.extension.org/72843
Recent studies of large modern dairies have found that respiratory disease remains an important problem for dairy workers, contributing to lost time and high turnover. Exposure to high levels of organic dusts generated during milking, moving cows, feeding and other tasks has been associated with increased inflammation and decreased lung function resulting in chronic obstructive pulmonary disease (COPD) and asthma-like diseases. Much research into the cause of respiratory disease in agriculture has focused on the role of endotoxins - a chemical component of Gram-negative bacteria. Recent research suggests that other components of these dusts such as Gram-positive bacteria and fungi are also important. Many new workers adapt to these exposures, and new evidence suggests that individual behavior and genetic factors play a key role in explaining why some workers are more susceptible. In addition several new studies of communities living in the vicinity of dairies and other livestock operations have shown that low level exposure to bioaerosols containing endotoxins and other microbial components at a very young age may be protective against the development of asthma later in life, possibly through priming of the immune system. Dairy producers are faced with interpreting complex research that may appear to show conflicting results. This presentation will review and discuss research into the impact of aerosols on respiratory health of dairy workers and residents living near dairies - the findings and implications for dairy producers.
Novel paper researched 3 vaccine preservatives: Aluminum, Ethyl Mercury, and Formaldehyde to assess if concerns regarding their presence in vaccines was valid in certain patient populations. Vaccine ingredient tables and graphics were included and determination that certain populations were at risk for negative health effects. Recommendations were made.
The presentation is regarding treatment and is not a study; it is a collection of observations made during the treatment of patients. The presentation covers food allergy management strategies, psychological and social impact of food allergy, risk management, food allergen desensitization treatment, and OIT treatment findings.
Presentation By: Dr Richard L Wasserman of Dallas Allergy Immunology
Beneficial Effects of Curcumin Inmaternal and Fetal Oxidativestress and Brain...Prof. Hesham N. Mustafa
This study was planned to explore the protective role of curcumin (Cur) against maternal and fetal oxidative stress and cerebral damage induced by lead (Pb) during pregnancy. Positively pregnant female rats were divided into seven groups: control group, Cur group (300 mg/kg of Cur/b.wt.), DMSO group (50% DMSO), two Pb-treated groups (exposed to 160 and 320 mg/kg b.wt./day of Pb acetate, respectively), and two groups treated with both Pb and Cur (exposed to Pb as previous groups together with 300 mg/kg b.wt./day of Cur). Treatments through oral gavage once a day started from gestation day 1 (GD1) till day 20 (GD20), where the mother rats of different experimental groups were sacrificed to obtain the fetuses. Different chemical parameters were assessed. Brain specimens of mother and fetal groups were processed with examination. The results displayed that Pb administration to pregnant rats resulted in a dose-dependent toxicity for both mothers and fetuses. Also, there was a significant rise in lipid peroxidation and decreased antioxidant enzyme activities in the brains of the different Pb-treated groups. The histological examination of the brain of treated dams and fetuses showed marked alterations. Co-treatment of Cur along with Pb caused a significant decrease in Pb levels as compared with those treated with Pb alone, improving the oxidative condition with amelioration of the brain’s histopathological changes. Co-administration of Cur could have ameliorative effect against Pb-induced neurotoxicity through the reduction of oxidative stress and reversal of histopathological changes.
Keywords:
Lead; Oxidative Stress; Brain; curcumin; Fetal toxicity
In this study, we focused on the effect of β-glucan supplementation of children with chronic respiratory problems. We measured the levels of cortisol, salivary IgE and cotinine in 56 children and evaluated the effect of 30 day supplementation with 100 mg/day oral dose of yeast-derived β-glucan. Our results showed strong decrease of cotinine and cortisol levels in saliva of β-glucan-supplemented children. The increase of total salivary IgE levels in both groups was not statistically significant. The positive effects of complex curative treatment using β-glucan were accompanied by increased physical endurance and by significant reduction of negative clinical problems of affected children.
Approximately 15 years ago, as few as 1 in 15,000 children were diagnosed with autism spectrum disorder. Fast forward to 10 years ago and the diagnosis rates jumped as high as 1 in 1,000. However, what is most alarming is that the diagnosis rate now stands at a shocking level of 1 in 50 children. It is thought that there may be a link between the rising diagnoses of this condition and the consumption or use of non-organic products.
Conventional Medicine Suggests that Physicians Watch and Wait rather than use antibiotics for mild ear infections. Rather than do that, it makes more sense to use natural therapies WHILE you are waiting. They often help resolve the issue so more aggressive pharmaceutical agents and ear tubes can be avoided.
Environmental Health: Children in minority communities
David Jones, Environmental Health and Safety, Duval County Health Department
April 22, 2005 - UNF Hispanic Health Issues Seminar
This is part 3 of an 8 part series of seminars on Hispanic Health Issues brought to you by the University of North Florida’s Dept. of Public Health, College of Health, a grant from AETNA, and the cooperation of Duval County Health Department.
Impact of Aerosols on Respiratory Health of Dairy Workers and Residents Livin...LPE Learning Center
The full proceedings paper is at: http://www.extension.org/72843
Recent studies of large modern dairies have found that respiratory disease remains an important problem for dairy workers, contributing to lost time and high turnover. Exposure to high levels of organic dusts generated during milking, moving cows, feeding and other tasks has been associated with increased inflammation and decreased lung function resulting in chronic obstructive pulmonary disease (COPD) and asthma-like diseases. Much research into the cause of respiratory disease in agriculture has focused on the role of endotoxins - a chemical component of Gram-negative bacteria. Recent research suggests that other components of these dusts such as Gram-positive bacteria and fungi are also important. Many new workers adapt to these exposures, and new evidence suggests that individual behavior and genetic factors play a key role in explaining why some workers are more susceptible. In addition several new studies of communities living in the vicinity of dairies and other livestock operations have shown that low level exposure to bioaerosols containing endotoxins and other microbial components at a very young age may be protective against the development of asthma later in life, possibly through priming of the immune system. Dairy producers are faced with interpreting complex research that may appear to show conflicting results. This presentation will review and discuss research into the impact of aerosols on respiratory health of dairy workers and residents living near dairies - the findings and implications for dairy producers.
Novel paper researched 3 vaccine preservatives: Aluminum, Ethyl Mercury, and Formaldehyde to assess if concerns regarding their presence in vaccines was valid in certain patient populations. Vaccine ingredient tables and graphics were included and determination that certain populations were at risk for negative health effects. Recommendations were made.
The presentation is regarding treatment and is not a study; it is a collection of observations made during the treatment of patients. The presentation covers food allergy management strategies, psychological and social impact of food allergy, risk management, food allergen desensitization treatment, and OIT treatment findings.
Presentation By: Dr Richard L Wasserman of Dallas Allergy Immunology
Beneficial Effects of Curcumin Inmaternal and Fetal Oxidativestress and Brain...Prof. Hesham N. Mustafa
This study was planned to explore the protective role of curcumin (Cur) against maternal and fetal oxidative stress and cerebral damage induced by lead (Pb) during pregnancy. Positively pregnant female rats were divided into seven groups: control group, Cur group (300 mg/kg of Cur/b.wt.), DMSO group (50% DMSO), two Pb-treated groups (exposed to 160 and 320 mg/kg b.wt./day of Pb acetate, respectively), and two groups treated with both Pb and Cur (exposed to Pb as previous groups together with 300 mg/kg b.wt./day of Cur). Treatments through oral gavage once a day started from gestation day 1 (GD1) till day 20 (GD20), where the mother rats of different experimental groups were sacrificed to obtain the fetuses. Different chemical parameters were assessed. Brain specimens of mother and fetal groups were processed with examination. The results displayed that Pb administration to pregnant rats resulted in a dose-dependent toxicity for both mothers and fetuses. Also, there was a significant rise in lipid peroxidation and decreased antioxidant enzyme activities in the brains of the different Pb-treated groups. The histological examination of the brain of treated dams and fetuses showed marked alterations. Co-treatment of Cur along with Pb caused a significant decrease in Pb levels as compared with those treated with Pb alone, improving the oxidative condition with amelioration of the brain’s histopathological changes. Co-administration of Cur could have ameliorative effect against Pb-induced neurotoxicity through the reduction of oxidative stress and reversal of histopathological changes.
Keywords:
Lead; Oxidative Stress; Brain; curcumin; Fetal toxicity
In this study, we focused on the effect of β-glucan supplementation of children with chronic respiratory problems. We measured the levels of cortisol, salivary IgE and cotinine in 56 children and evaluated the effect of 30 day supplementation with 100 mg/day oral dose of yeast-derived β-glucan. Our results showed strong decrease of cotinine and cortisol levels in saliva of β-glucan-supplemented children. The increase of total salivary IgE levels in both groups was not statistically significant. The positive effects of complex curative treatment using β-glucan were accompanied by increased physical endurance and by significant reduction of negative clinical problems of affected children.
Approximately 15 years ago, as few as 1 in 15,000 children were diagnosed with autism spectrum disorder. Fast forward to 10 years ago and the diagnosis rates jumped as high as 1 in 1,000. However, what is most alarming is that the diagnosis rate now stands at a shocking level of 1 in 50 children. It is thought that there may be a link between the rising diagnoses of this condition and the consumption or use of non-organic products.
Conventional Medicine Suggests that Physicians Watch and Wait rather than use antibiotics for mild ear infections. Rather than do that, it makes more sense to use natural therapies WHILE you are waiting. They often help resolve the issue so more aggressive pharmaceutical agents and ear tubes can be avoided.
Environmental Health: Children in minority communities
David Jones, Environmental Health and Safety, Duval County Health Department
April 22, 2005 - UNF Hispanic Health Issues Seminar
This is part 3 of an 8 part series of seminars on Hispanic Health Issues brought to you by the University of North Florida’s Dept. of Public Health, College of Health, a grant from AETNA, and the cooperation of Duval County Health Department.
Science Cabaret by Dr. Rodney Dietert "How to train your super organism..via ...Kitty Gifford
Attendees (and their microbes) at this event enjoyed a lively discussion on how we might better interact with our environment to support a healthier life for ourselves and our children. Think with your microbes about why we have to suffer from ever-increasing numbers of debilitating chronic diseases (asthma, food allergies, diabetes, autoimmune conditions, obesity, heart disease and cancer).
with Dr. Rodney Dietert, Cornell University Professor, Department of Microbiology and Immunology
Dr. Rodney Dietert is an internationally-known author, lecturer, scientist, book series editor, and educator. He is the author of Strategies for Protecting Your Child’s Immune System, and Science Sifting: Tools for Innovation in Science and Technology.
How and Why Pesticides Affect Our Healthmomasunite
Dr. Myrto Ashe, MD, MPH presents scientific evidence that pesticides affect the health of our children. She explains the mechanism of how pesticides disrupt the health of children.
The American Medical Association recommneds people take a daily multi-vitamin. The multi-vitamin is outdated and 20th century technology. 21st century technology efficacious interventions point to food-first solutions.
GENE ENVIRONMENT INTERACTION
Subtle differences in one person’s genes can cause them to respond differently to the same environmental exposure as another person. As a result, some people may develop a disease after being exposed to something in the environment while others may not.
As scientists learn more about the connection between genes and the environment, they pursue new approaches for preventing and treating disease that consider individual genetic codes.
Gene–environment interactions in development and disease lovely - 2016 - wi...BARRY STANLEY 2 fasd
ETHANOL: THE EMPEROR OF ALL TERATOGENS
An account of gene/environment interaction in relation to the petro chemical age, and the historical significance of alcohol as teratogen.
6th International Disaster and Risk Conference IDRC 2016 Integrative Risk Management - Towards Resilient Cities. 28 August - 01 September 2016 in Davos, Switzerland
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2014-0826 Davos
1. Preventing chronic diseases by
reducing exposures to endocrine
disrupting compounds.
John Peterson Myers, Ph.D.
Environmental Health Sciences
and Carnegie Mellon University
Environmental Health Sciences
3. Endocrine disruption
1. Related to today’s human
epidemics.
2. Ubiquitous exposure
3. Powerful effects even at low doses
4. We know enough now to start eliminating
exposures and making people healthier
Environmental Health Sciences
4. 19 Feb 2013: WHO – UNEP report
Environmental Health Sciences
5. 2013 WHO-UNEP report
Many endocrine related disorders are on the rise,
far too rapidly to be a change in gene frequency.
~800 chemicals in common use are known to disrupt
endocrine function.
Human and wildlife exposure is ubiquitous.
Numerous laboratory, wildlife and epidemiological
studies are consistent with endocrine disruption impacts
on human health.
Disease risk due to EDCs may be significantly
underestimated.
Significant opportunities for disease prevention by
reducing exposures may be within reach.
Environmental Health Sciences
6. Glucocorticoid hormone
Tumor suppressing
protein
Cell nucleus
Receptor
Environmental Health Sciences Kaltreider et al. 2002
8. Revolution in science
1. Low doses matter a lot
2. Events in the womb don’t stay in the womb
3. The tools we have used to assess safety are
profoundly misguided
Environmental Health Sciences
9. Same strain of mice
Same caloric intake
Same activity levels
Environmental Health Sciences
Newbold et al. 2005, 2007
1 part per billion
10. 2.5 parts per billion of atrazine
Environmental Health Sciences
12. 1,000,000
10,000
100
0.1
Recommended application
Run-off
Streams
Surface water
Safe for drinking water
Rain
Environmental Health Sciences
1
PPB
Safe short term
Hayes et al. 2002
ATRAZINE
This result
13. Revolution in science
1. Low doses matter a lot
2. Events in the womb don’t stay in the womb
3. The tools we have used to assess safety are
profoundly misguided
Environmental Health Sciences
14. Kidneys
Control
Bladder
Testes
Environmental Health Sciences
Kidneys
Bell Jones et al. 2007
T&E2 Capsule T&E2 Capsule
Bladder
Testis
BPA
15. Revolution in science
1. Low doses matter a lot
2. Events in the womb don’t stay in the womb
3. The tools we have used to assess safety are
profoundly misguided
Environmental Health Sciences
16. 1 part per billion What about 1000 ppb?
Same strain of mice
Same caloric intake
Same activity levels
Environmental Health Sciences
Newbold et al. 2005, 2007
19. Revolution in science
Epigenetics
and
endocrine disruption
Environmental Health Sciences
20. OLD:
Toxic components work by
overwhelming the body’s
defenses by brute force.
Environmental Health Sciences
NEW:
Some compounds work
by hijacking control
of gene expression.
21. OLD:
Toxic components work by
overwhelming the body’s
defenses by brute force.
Environmental Health Sciences
NEW:
Some compounds work
by hijacking control
of gene expression.
Only high levels
matter
“Normal” levels
which could not
even be measured
20 years ago
matter
23. A new way forward. the 4th R:
Redesign
Environmental Health Sciences
24. Designing against EDC hazard
Tiered Endocrine Disruptor Protocol
Voluntary… based on current science
Not about current replacements
Economically efficient
Driven by endocrinological principles
Designed to evolve with the science
Environmental Health Sciences