Anemo 2015-02-Hoffman- Considerazioni economiche nella PBManemo_site
This document provides a disclaimer and disclosure of past fees, honoraria, or travel expenses received by Dr. Axel Hofmann from various companies related to transfusion medicine and patient blood management. It then outlines four sections on:
1. Cost of Transfusion - discusses cost drivers like blood shortage and newly emerging pathogens.
2. Cost Effectiveness of Transfusion - questions whether transfusion truly improves outcomes and presents evidence that liberal transfusion strategies are not cost-effective and may be harmful.
3. Observational and randomized controlled trial evidence linking liberal transfusion to increased infection rates, length of stay, and costs.
4. Real life studies showing the costs of liberal transfusion strategies in large
2013 anemo nurse - albano - gestione del recupero perioperatorioanemo_site
This document discusses the postoperative recovery process and the use of autologous blood transfusion to reduce the need for allogenic blood transfusions. It provides details on maximizing autologous blood collection based on patient weight, guidelines for reinfusion of salvaged blood including sedimentation time and stability criteria, and concludes that careful consideration by medical staff and adherence to scientific methodology and rigor is important when discussing this issue.
Anemo 2015-02-Hoffman- Considerazioni economiche nella PBManemo_site
This document provides a disclaimer and disclosure of past fees, honoraria, or travel expenses received by Dr. Axel Hofmann from various companies related to transfusion medicine and patient blood management. It then outlines four sections on:
1. Cost of Transfusion - discusses cost drivers like blood shortage and newly emerging pathogens.
2. Cost Effectiveness of Transfusion - questions whether transfusion truly improves outcomes and presents evidence that liberal transfusion strategies are not cost-effective and may be harmful.
3. Observational and randomized controlled trial evidence linking liberal transfusion to increased infection rates, length of stay, and costs.
4. Real life studies showing the costs of liberal transfusion strategies in large
2013 anemo nurse - albano - gestione del recupero perioperatorioanemo_site
This document discusses the postoperative recovery process and the use of autologous blood transfusion to reduce the need for allogenic blood transfusions. It provides details on maximizing autologous blood collection based on patient weight, guidelines for reinfusion of salvaged blood including sedimentation time and stability criteria, and concludes that careful consideration by medical staff and adherence to scientific methodology and rigor is important when discussing this issue.
2013 anemo nurse - weltert - rischi e benefici delle trasfusionianemo_site
The document discusses the history and risks of blood transfusions from several perspectives. It covers the historical view of transfusions as analogous to filling a bathtub, the rare exceptions of vampiric transfusions, and the view of transfusions as a "silver bullet." It also discusses the conflict between transfusions and transplants as well as the problems posed by anemia and transfusions. The document advocates for a multimodal approach to reduce dependence on allogeneic blood transfusions, especially in high-risk cardiac surgery patients.
09.00 inghilleri anemo 2015_cost of blood_defanemo_site
The document discusses the costs associated with blood transfusion. It provides cost estimates for various blood components from different countries, with the cost of a single red blood cell concentrate ranging from 130-180 euros. It also examines the total cost of administering a blood transfusion, which is much higher than just the acquisition cost of the blood component, ranging from 2-4 times higher. A study using an activity-based costing model at four hospitals in the US and Europe found the mean total cost per red blood cell unit transfused was $760.82 plus or minus $293.74. Appropriate use of blood components is key to improving their cost-effectiveness.
2014 orthopea milano - rondinelli - preparazione del paziente chirurgico pro...anemo_site
2014 orthopea milano - rondinelli - preparazione del paziente chirurgico protesico predepostio e terapia marziale quale ruolo e modello di strategia operativa
2013 anemo nurse - weltert - rischi e benefici delle trasfusionianemo_site
The document discusses the history and risks of blood transfusions from several perspectives. It covers the historical view of transfusions as analogous to filling a bathtub, the rare exceptions of vampiric transfusions, and the view of transfusions as a "silver bullet." It also discusses the conflict between transfusions and transplants as well as the problems posed by anemia and transfusions. The document advocates for a multimodal approach to reduce dependence on allogeneic blood transfusions, especially in high-risk cardiac surgery patients.
09.00 inghilleri anemo 2015_cost of blood_defanemo_site
The document discusses the costs associated with blood transfusion. It provides cost estimates for various blood components from different countries, with the cost of a single red blood cell concentrate ranging from 130-180 euros. It also examines the total cost of administering a blood transfusion, which is much higher than just the acquisition cost of the blood component, ranging from 2-4 times higher. A study using an activity-based costing model at four hospitals in the US and Europe found the mean total cost per red blood cell unit transfused was $760.82 plus or minus $293.74. Appropriate use of blood components is key to improving their cost-effectiveness.
2014 orthopea milano - rondinelli - preparazione del paziente chirurgico pro...anemo_site
2014 orthopea milano - rondinelli - preparazione del paziente chirurgico protesico predepostio e terapia marziale quale ruolo e modello di strategia operativa
Innovazioni tecnologiche che hanno avuto un impatto organizzativo sulla cura ...Free Your Talent
L'elaborato di Maria Cannalire vincitrice della borsa di studio ISTUD per il miglior elaborato sul tema "Descrivere un’innovazione tecnologica che ha avuto un impatto organizzativo sulla cura delle persone" per la partecipazione alla XV edizione del Programma Scienziati in Azienda
This study analyzed 45 observational studies including over 272,000 patients to determine the association between red blood cell transfusion and morbidity and mortality in high-risk hospitalized patients. The analysis found that in 42 of the 45 studies, the risks of red blood cell transfusion outweighed the benefits, with transfusion associated with increased risk of death, infections, multi-organ dysfunction syndrome, and acute respiratory distress syndrome. A meta-analysis found that transfusion was associated with 70% higher odds of death and 80% higher odds of developing an infectious complication. The study suggests current transfusion practices may need reevaluation given the risks appear to outweigh the benefits in most patients.
The document discusses the results of a study on the effects of a new drug on memory and cognitive function in older adults. The double-blind study involved 100 participants aged 65-80 who were given either the drug or a placebo daily for 6 months. Researchers found that those who received the drug performed significantly better on memory and problem-solving tests at the end of the study compared to those who received the placebo.
Bucci anemo 2015 - Glicocalice endoteliale la centrale della periferiaanemo_site
The document discusses the endothelial glycocalyx layer (EGL), which is a complex mesh-like network made of sugars and proteins located on the surface of endothelial cells. The EGL plays three main roles: 1) it acts as a mechanotransducer of fluid shear stress to the endothelial cells, triggering biochemical responses; 2) it modulates permeability in the exchange of water between blood and tissues; 3) it regulates interactions between blood cells and endothelial cells, influencing inflammation and coagulation. The EGL is crucial for endothelial cell mechanosensing and transduction of blood flow forces, maintaining homeostasis of the circulatory system.
Anemo 2015-Beverina- Acido tranexamico: efficacia in chirurgia protesica orto...
2013 anemo nurse - rondinelli - anemia meglio trattarla
1. ANEMIA: meglio trattarla!
MARIA BEATRICE RONDINELLI
Azienda Ospedaliera San Camillo-Forlanini,Roma
Milano, 28/06/13
2. MONDO TRASFUSIONALE OGGI
Emovigilanza
Virus emergenti
Nuove patologie
RISCHIO
TRASFUSIONALE
TRALI
ATR
HtR
GVHD
TRIM
STORAGE LESION
TRALI
SANGUE :RISORSA LIMITATA
INVECCHIAMENTO DELLA
POPOLAZIONE
DIRETTIVE EUROPEE
DECRETI LEGISLATIVI
LINEE GUIDA
RACCOMANDAZIONI
AUMENTO DEI
PAZIENTI
CHIRURGICI
AUMENTO DEI COSTI TRASFUSIONALI
DIRETTI ED INDIRETTI
EMOCOMPONENTI DI GRADO
FARMACEUTICO
11. Consulenza
trasfusionale
preoperatoria
Management
stato anemico
basale
Selezione
programma
autotrasfusionale
Valutazione
terapia di
supporto
Ottimizzazione
percorsi
terapeutici
antiemorragici
12. Anamnesi familiare e
personale
Screening di laboratorio
1 e 2° livello
Diatesi
trombofilica
Interazioni
farmacologiche
Diatesi
emorragica
Tromboelastometrie
Studio di
Aggregometria
piastrinica
Ottimizzazione percorsi
antiemorragici
13. MSBOS
• ( Maximum Surgical Blood Ordering Schedule
• =/> 2 UNITA’ nella casistica del proprio
ospedale
PSBOS
• Patient Specific Blood Orderyng System
• Emoglobina, Ematocrito, Peso, Volemia
TIMING
• Tempo necessario prima di ogni intervento per
la rigenerazione ematica.
• Quantità ematica raccolta, Emoglobina Basale
14. KEATING EM. Et al “Predictors of transfusion risk in elective
knee surgery. Clin Orthopedics. 2008
15.
16. Shander A. et al.” Prevalence and outcomes of
anemia in surgery”: a sistematic review of the
literature. Am J Med 2004
Kurtz Sm., Ong KL., et al “ International
survey of primary and revision total Knee
Replacement. Int. Orthopedic 2011
PREOPERATIVE ANEMIA:
WARNING!!
20. Uno stato anemico non diagnosticato è
presente in una percentuale compresa tra il
5 ed il 75% dei pazienti chirurgici
Età, Anamnesi, Comorbilità ,
Correlazioni farmacologiche
Parametri laboratoristici basali
e di funzionalità d’organo
Grado di complessità
dell’intervento chirurgico
26. CRITERI DIAGNOSTICI PER SIDEROPENIA
A
• Hb< 10,5 F e < 13,5 M
• MCV < 80 fl
B
• Ferritina sierica < 15 ng/dL
• Sideremia < 60 mcg/dL
C
• Recettore x TRF solubile >28 nM
D
• Assenti depositi di ferro nei macrofagi midollari
E
• Saturazione della TRF < 15%
27. RISERVE MARZIALI DEL PAZIENTE SIDEROPESSI
Capacità
eritropoietica
del paziente
MIDOLLARE
Tempo di
risposta
midollare
IL1
IL6
EPO ENDOGENA EPO ESOGENA
Goodnough LT . BLOOD 2000 Erytthropoietin,iron and erythropoiesis
28.
29. Stato infiammatorio
postoperatorio
Interleuchina 6 Proteina C reattiva
-7 -1 0 1 7 14 21 28 35 42 49
Giorni
IL-6 (U/ml)
20
15
10
5
0
4
-7 -1 0 7 10 14 21 28 35 42
80
60
40
20
Pazienti sottoposti a ricostruzione dell’anca.
Incremento post-operatorio dei livelli di interleuchina 6: picco massimo al giorno +1 e normalizzazione al giorno +7.
Marcato aumento dei livelli di PCR: picco massimo al giorno +4, ancora significativo al giorno +14 (*p<0,001).
Biesma DH et al. Eur J Clin Invest 1995; 25:383-389
Giorni
PCR (mg/l)
0
4
100
*
*
*
* *
30. ANEMIA PERIOPERATORIA MEGLIO TRATTARLA ……
SICURAMENTE SI!!
ALGORITMI DI
SUPPORTO
CONDIVISIONE
INTERDISCIPLI
NARE
TERAPIE ADEGUATE
31. GRAZIE PER LA CORTESE ATTENZIONE
mrondinelli@scamilloforlanini.rm.it