This document outlines lecture topics for blood and neuroscience modules covering several semesters. The blood module covers plasma proteins, heme synthesis, abnormalities like porphyria, iron metabolism, hemoglobinopathies, thalassemias, bilirubin, and vitamin K. The neuroscience module covers neurotransmitters, brain lipids, acetylcholine and catecholamine metabolism, cerebrospinal fluid composition and the blood brain barrier, and how the brain's metabolic needs change in different states. Each lecture includes objectives for students to understand key concepts and processes related to the topic.

1. BLOOD MODULE, INFLAMMATION & NEOPLASIA MODULE
SEMESTER-I (Batch – II, 2013) SMC
LECTURES
1. Compositionof Plasma and Plasma Proteins
2. Structure of Heme
3. Synthesis of Heme & Variants of Hemoglobin
4. Abnormalities in synthesis heme (porphyria)
5. Iron Metabolism
6. VitaminB12 & FolicAcid
7. Hemoglobinopathies
8. Thalassemiasyndrome
9. Heme Degradation
10. HyperbilirubinemiaandJaundice
11. VitaminK
Compositionof Plasma and Plasma Proteins
Lecture Objectives:
By the end ofthis lecture the studentshould be able to:
1. Describe the compositionof blood.
2. State normal valuesof bloodandplasmavolume.
3. Describe the compositionof plasma.
4. List typesof plasmaproteins.
5. State the normal plasmaproteinconcentration.
6. Describe the Biochemical functionsof plasmaproteins.
7. Outline the differentcausesof low plasmaproteinconcentration.
Structure of Heme, Synthesis of Heme & Variants of Hemoglobin
Abnormalities in synthesis Heme (porphyria)
Lecture Objectives:
By the end ofthis lecture the studentshould be able to:
1. Know the relationship between porhyrins and heme
2. Know Heme structure in relation to protein hemoglobin
3. Be familiar with how heme is synthesized and Identify the rate limiting step
4. Describe the site of effect of certain drugs on heme biosynthesis and its clinical
importance
5. Identify how blocking in one of the enzyme involved in heme biosynthesis will affect the
mode of presentation of the disease.
6. Identify the most common type of porphyrias & its cause

2. Hemoglobinopathies
Lecture Objectives:
By the end ofthis lecture the studentshould be able to:
1. reviewthe normal structure-functionrelationshipsof hemoglobinandexpressionof globin
genes
2. examine the hemoglobinopathiesasdisordersof hemoglobinstructure,or α- or β-globingene
expression
Thalassemiasyndrome
Lecture Objectives:
By the end ofthis lecture the studentshould be able to:
1. Knowthe Diverse groupof disorderswhichmanifestasanemiaof varyingdegrees.
2. Knowthe defective productionof globinportionof hemoglobinmolecule.
3. Knowthe Distributionof disease worldwide.
4. Describe the disease eitherhomozygous orheterozygousdefect.
5. Knowthe Defectresultsfromabnormal rate of synthesisinone of the globinchains.
VitaminK
Lecture Objectives:
By the end ofthis lecture the studentshould be able to:
1. Distinguishfatsolublevswatersoluble vitamins
2. knowthe Characteristicfeaturesof Fatsoluble vitamins
3. Describe The principal role of vitaminKincoagulation
4. A) formationof Y-carboxyglutamate
5. B) interactionof prothrombinwithplatelets
6. C) role of vit.K inotherproteins
7. Identifyfoodsourcesanddailyrequirementof vit.K
8. Determine The deficiencyinthe newbornandinadults
9. Knowhow toxicityof vitaminK can occur.

3. NEUROSCIENCES MODULE SEMESTER-III
LECTURES
1. Classificationand functionsof Neurotransmitters
2. Brain Lipids
3. Metabolismof Acetylcholine andcatecholamine
4. Chemical CompositionofCSF and changes in diseasedState
5. Chemical compositionof BBB + Breach of BBB
6. Brain needsin differentmetabolicstates
Classification and functions of Neurotransmitters
Lecture Objectives:
By the end ofthis lecture the studentshould be able to:
1. Define aNeurotransmitter.
2. How Neurotransmitters are classified?
3. How Neurotransmitters are synthesizedinthe body?
4. UnderstandThe chemical transmission throughneurotransmitters.
5. Compare and contrastthe effectsof Neurotransmitterswhichare one of three :ionotropic,
metabotropicormodulatory.
6. ExlainUnderwhatconditionsandhow are theyreleased?
7. Understand What happenstothe presynapticandthe postsynapticneurononce they are
released?
Chemical CompositionofCSF and changes in diseasedState
Lecture Objectives:
By the end ofthis lecture the studentshould be able to:
1. Describe production,circulation,andabsorptionof CSF.
2. List majorfunctionsof CSFinrelationto the CNS.
3. Discussnormal CSFvalues.
4. Describe conceptof the cranial vaultwitha fixedtotal volumeinassociationwithintracranial
pressure.
5. Explaindifferencesbetweenthe twotypesof hydrocephalus.

4. Chemical compositionof BBB + Breach of BBB
Lecture Objectives:
By the end ofthis lecture the studentshould be able to:
1. Describe the bloodbrainbarrier
2. Explainthe compositionof bloodbrainbarrier
3. Know the History of existence of such a barrier
4. Knowthe Characteristicfeatures orstructure of barrier
5. Knowthe Selectivityof molecules throughBBB
6. Explainthe Bloodbrain barriertransportmechanism
7. Explainthe Bloodbrain barriertransportmechanismfor glucose,aminoacids,lipids.o2,C02.
8. Know the CircumventricularOrgans where bloodbrainbarrieris weak
9. Knowthe Conditionsthatrupture the BBB
Brain needsin differentmetabolicstates
Lecture Objectives:
By the end ofthis lecture the studentshould be able to:
1. Interconnectionof metabolicpathways
2. Metabolicprofile of brain during Food intake,starvation and obesity
3. Fuel choice during exercise
4. Ethanol alters energymetabolism
5. Hormonal regulationof metabolism