I. The document summarizes research on matrix metalloproteinases (MMPs), a family of enzymes that degrade extracellular matrix and participate in vascular remodeling. It discusses 12 MMPs and their roles in atherosclerotic plaque development and rupture. II. Studies have shown several MMPs (MMP-1, -2, -3, -9, -12) present in atherosclerotic plaques and implicated in plaque development and rupture. MMP-8 was also found to be associated with collagen degradation in rupture-prone shoulder regions of plaques. III. The document concludes that MMP-3 and its inhibitor, TIMP-3, are overexpressed in aneurysmal aorta, suggesting inhibition of