This ppt is about the variations in metabolic processes between different types of cells in different organs of our body. The reasons for the variations are also descried. This is the first set of slides on the topic.
24.1 Digestion and Absorption of Carbohydrates
24.2 Hormonal Control of Carbohydrate Metabolism
24.3 Glycogen Synthesis and Degradation
24.4 Gluconeogenesis
24.5 The Pentose Phosphate Pathway
24.6 Glycolysis
24.7 Terminology for Glucose Metabolic Pathways
24.8 The Citric Acid Cycle
24.9 The Electron Transport Chain
24.10 Oxidative Phosphorylation
24.11 ATP Production for the Complete Oxidation of Glucose
24.12 Importance of ATP
24.13 Non-ETC Oxygen-Consuming Reactions
24.14 B-Vitamins and Carbohydrate Metabolism
carbohydrate metabolism, Glycolysis, metabolic process of carbohydrates, EMP ...RajkumarKumawat11
carbohydrate metabolism, Glycolysis, metabolic process of carbohydrates, EMP pathway, Embden- Meyerof-Paranas pathway, cabohydrate metabolic process for study, A presentation on cabohydrate metabolic process i.e. Glycolysis
This ppt is about the variations in metabolic processes between different types of cells in different organs of our body. The reasons for the variations are also descried. This is the first set of slides on the topic.
24.1 Digestion and Absorption of Carbohydrates
24.2 Hormonal Control of Carbohydrate Metabolism
24.3 Glycogen Synthesis and Degradation
24.4 Gluconeogenesis
24.5 The Pentose Phosphate Pathway
24.6 Glycolysis
24.7 Terminology for Glucose Metabolic Pathways
24.8 The Citric Acid Cycle
24.9 The Electron Transport Chain
24.10 Oxidative Phosphorylation
24.11 ATP Production for the Complete Oxidation of Glucose
24.12 Importance of ATP
24.13 Non-ETC Oxygen-Consuming Reactions
24.14 B-Vitamins and Carbohydrate Metabolism
carbohydrate metabolism, Glycolysis, metabolic process of carbohydrates, EMP ...RajkumarKumawat11
carbohydrate metabolism, Glycolysis, metabolic process of carbohydrates, EMP pathway, Embden- Meyerof-Paranas pathway, cabohydrate metabolic process for study, A presentation on cabohydrate metabolic process i.e. Glycolysis
This PPT contains HMP Shunt, Reactions of the pathway i.e. Oxidative & Non-oxidative. Glucose-6-Phosphate dehydrogenase (G6PD) deficiency, Regulation of Pathway, Significance of HMP shunt
Honest Reviews of Tim Han LMA Course Program.pptxtimhan337
Personal development courses are widely available today, with each one promising life-changing outcomes. Tim Han’s Life Mastery Achievers (LMA) Course has drawn a lot of interest. In addition to offering my frank assessment of Success Insider’s LMA Course, this piece examines the course’s effects via a variety of Tim Han LMA course reviews and Success Insider comments.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
Instructions for Submissions thorugh G- Classroom.pptxJheel Barad
This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
2. • (B1 3.4) Define and differentiate the pathways of
glycogen metabolism.
• Learning objectives
• Distinguish the symptoms that arise from
glycogen storage diseases that affect the muscle,
the liver, and lysosomes and explain their
biochemical basis.
• Select laboratory tests that would contribute to
the diagnosis of glycogen storage diseases.
3.
4. Glycogen storage diseases
• Diseases associated with glycogen synthesis
and degradation
• Due to defects in enzymes associated with
glycogen metabolism
• This leads to deposition of abnormal forms of
glycogen
5.
6. Von Gierke’s disease ( Glycogen
storage disease I)
• Incidence 1 per 2 lac persons
• Autosomal recessive
• Clinical features-
• Fasting hypoglycemia– due to deficiency of
glucose 6 phosphatase, glucose is not released
from liver into blood
• Lactic acidosis- Glucose 6 phosphate enters
glycolysis forming pyruvate and lactate –
increased lactate levels
7. • Hyperlipidemia- Due to hypoglycemia, there
occurs increased fat breakdown-
• increased production of acetyl CoA –
Increased cholesterol-
• Increased production of acetyl CoA- Formation
of ketone bodies ( Acidemia and acidosis)
8. • Hyperuricemia- due to diversion of glucose 6
phosphate to pentose phosphate pathway
leading to increased synthesis of ribose 5
phosphate– which forms purine nucleotides–
degraded to uric acid
9.
10.
11. HMP shunt/ PPP ( Pentose phosphate
pathway)
• (B1 3.4) Define and differentiate the pathway of HMP shunt
• Learning objectives
• For different tissue type, compare and contrast the overall
purpose of the pentose pathway, and its reactant and
products, and its cellular localization.
• Describe the role of reduced glutathione in the body ,and the
contribution of NADPH to its formation.
• Explain the biochemical basis of drug induced hemolytic
anemia observed in glucose-6-phosphate dehydrogenase
deficiency.
• Explain the function of transketolase in the non oxidative
branch of the pentose phosphate pathway.
12. • Pentose phosphate pathway is also called as HMP
pathway or HMPshunt or phosphogluconate
pathway.
• This is an alternative pathway to glycolysis and
TCAcycle for the oxidation of glucose.
• HMPshunt is more anabolic in nature.
13. • It is concerned with the biosynthesis of NADPH &
pentoses.
• About 10% of glucose entering in this
pathway/day.
• The liver & RBC metabolise about 30% of glucose
by this pathway.
14. Location of the pathway
• The enzymes are located in the cytosol.
• The tissues such as liver, adipose tissue, adrenal
gland, erythrocytes, testes & lactating mammary
gland, are highly active in HMPshunt.
• Most of these tissues are involved in biosynthesis of
fatty acids and steroids which are dependent on the
supply of NADPH.
15. HMPshunt-unique multifunctional
pathway
• It starts with glucose 6-phosphate.
• NoATPis directly utilized or produced in HMP
shunt
• It is multifunctional pathway, several
interconvertible substances produced, which are
proceed in different directions in the metabolic
reactions
16. Reactions of the pathway
• Reactions of the pathway:
• Divided into Two phases oxidative & non – oxidative.
• Oxidative phase
• Step:1
• Glucose 6- phosphate is oxidised by NADP- dependent
Glucose 6- phosphate dehydrogenase (G6PD), 6-
phosphogluconolactone is formed.
• NADPH is formed in this reaction and this is a rate limiting
step.
17. • Step:2
• 6-phosphogluconolactone is hydrolysed by glucono lactone
hydrolase to form 6-phosphogluconate.
• Step : 3
• The next reaction involving the synthesis of NADPH and is
catalysed by 6 – phosphogluconate dehydrogenase to
produce 3 keto 6 – phosphogluconate which then undergoes
decarboxylation to give ribulose 5 – phosphate.
18. Non-Oxidative Phase
• Step: 4
• The ribulose -5-phosphate is then isomerized to
ribose -5-phosphate or epimerised to xylulose -5-
phosphate
• Step: 5 Transketolase reaction
• Transketolase is a thiamine pyrophosphate (TPP)
dependent enzyme.
19. • It transfers two-carbon unit from xylulose 5-
phosphate to ribose 5-phosphate to form a 7-
carbon sugar, sedoheptulose 7-phosphate and
glyceraldehyde 3 – phosphate.
20. • Step: 6 Transaldolase reaction
• Transaldolase brings about the transfer of a 3 –
carbon fragment from sedoheptulose 7-phosphate
to glyceraldehyde 3-phosphate to give fructose 6-
phosphate & 4 – carbon erythrose 4 – phosphate.
21. • Step: 7 Second transketolase Reaction
• In another transketolase reaction a 2 – carbon unit
is transferred from xylulose 5 – phosphate to
erythrose 4 – phosphate to form fructose 6 –
phosphate & glyceraldehyde 3 – phosphate.
• Fructose 6 – phosphate & glyceraldehyde 3 –
phosphate are further metabolized by glycolysis &
TCAcycle.
25. +
Significance of HMPShunt
• HMPshunt is unique in generating two important products-
pentoses and NADPH
• Importance of pentoses:
In HMPshunt, hexoses are converted into pentoses, the
most important being ribose 5 – phosphate.
• This pentose or its derivatives are useful for the synthesis of
nucleic acids (DNA & RNA)
• Many nucleotides such asATP, NAD , FAD & CoA
26. Importance of NADPH
• NADPH is required for the bio synthesis of fatty
acids and steroids.
• NADPH is used in the synthesis of certain amino
acids involving the enzyme glutamate
dehydrogenase.
• Free radical Scavenging
• The free radicals (super oxide, hydrogen peroxide)
are continuously produced in all cells.
27. • These will destroy DNA, proteins, fatty acids & all
biomolecules & in turn cells are destroyed.
• The free radicals are inactivated by the enzyme
systems containing SOD, POD & glutathione
reductase.
• Reduced GSH is regenerated with the help of
NADH.
28. • Erythrocyte Membrane intigrity
• NADPH is required by the RBC to keep the
glutathione in the reduced state.
• In turn, reduced glutathione will detoxify the
peroxides & free radicals formed within the RBC.
• NADPH, glutathione & glutathione reductase
together will preserve the intigrity of RBC
membrane.
29.
30. • Prevention of Met-Hemoglobinemia
• NADPH is also required to keep the iron of
hemoglobin in the reduced (ferrous) state & to
prevent the accumulation of met-hemoglobin.
• Met-hemoglobin cannot carry the oxygen.
31. • Detoxification of Drugs
• Most of the drugs and other foreign substances are
detoxified by the liver microsomal P450 enzymes,
with the help of NADPH.
• Lens of Eye:
• Maximum concentration of NADPH is seen in lens
of eye.
• NADPH is required for preserving the
transparency of lens.
32. • Macrophage bactericidal activity:
NADPH is required for the production of reactive
oxygen species (ROS) by macrophases to kill
bacteria.
• Availability of Ribose:
Ribose & Deoxy – ribose are required for DNA&
RNA synthesis.
33.
34. • Ribose is also necessary for nucleotide co –
enzymes.
• Reversal of non – oxidative phase is present in all
tissues, by which ribose could be made available.
• What aboutATP
ATP is neither utilized nor produced by the HMP
shunt.
• Cells do not use the shunt pathway for energy
production.
35. Regulation of HMPShunt
The entry of glucose 6-phosphate into the pentose
phosphate pathway is controlled by the cellular
concentration of NADPH
NADPH is a strong inhibitor of glucose 6-phosphate
dehydrogenase (G6PD)
NADPH is used in various pathways, inhibition is
relieved & the enzyme is accelerated to produce
more NADPH
36. The synthesis of glucose 6-phosphate
dehydrogenase is induced by the increased
insulin/glucagon ratio after a high carbohydrate
meal.
37. Glucose-6-phosphate dehydrogenase deficiency (G6PD)
• It is an inherited sex – linked trait.
• It is more severe in RBC.
• Decreased activity of G6PD impairs the synthesis of
NADPH in RBC.
• This results in the accumulation of met hemoglobin
& peroxides in erythrocytes leading to hemolysis.
38.
39.
40.
41. • The deficiency is manifested only when exposed to
certain drugs or toxins, e.g.intake of antimalarial
drug like primaquine & ingestion of fava
beans(favism) & sulpha drugs also parecipitate the
hemolysis
42. Some patients developed severe symptoms
• Jaundice, decrease in Hb, destruction of RBCs.
• In deficiency of G6PD, Hb can no longer be maintained in the
reduced form.
• Hb molecules then cross-link with one another to form
aggregates called Heinz bodies on membranes.
• Membranes damaged by the Heinz bodies & ROS become
deformed & the cell undergos LYSIS Hemolytic anemia
43.
44. G6PD deficiency & malaria
• G6PD deficiency is associated with resistance to malaria
(caused by plasmodium infection)
• The parasite requires reduced glutathione for its survival,
which will not be available in adequate amounts in
deficiency of G6PD.
• Met – hemoglobinemia
• G6PD deficient persons will show increased Met –
hemoglobin in circulation, even though cyanosis may not
be manifested.
45. Thiamine Deficiency
• The transketolase activity is measured in RBCs is an index
of the thiamine status of an individual.
• The occurrence & manifestation of Wernickes korsakoffs
syndrome (encephalopathy) which is seen in alcoholics &
those with thiamine deficiency is due to a genetic defect in
the enzyme transketolase.
• The symptoms include mental disorder, loss of memory &
partial paralysis.