The document describes a multi-year global research program called Innovative Teaching and Learning Research sponsored by Microsoft Partners In Learning. The research aims to investigate the factors that promote the transformation of teaching practices and the impact on student learning outcomes across different country contexts. It will provide evidence to policy-makers on what teaching practices work to change teacher practices and impact student development of 21st century skills. The goal is to develop a scalable research and monitoring system informed by international standards that countries and schools can use to measure change over time.