1 sun 1600 dieffenbach cdc prevention conference 30 years of aids - science and leasderhip draft for 8-14-2011 final

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This document summarizes 30 years of progress in HIV/AIDS research and leadership by the National Institute of Allergy and Infectious Diseases. It discusses advances in prevention technologies for reducing HIV incidence, including antiretroviral treatment, pre-exposure prophylaxis, medical male circumcision, sexually transmitted infection treatment, microbicides, HIV vaccines, and their estimated effects. The goals of this research are reducing new HIV infections, increasing access to care to optimize health outcomes, and reducing disparities related to HIV.

Thirty Years of HIV/AIDS;
Science and Leadership

Carl W. Dieffenbach, Ph.D.
Director, Division of AIDS,
NIAID, NIH
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HIV Incidence Reduction by
Prevention Technologies
Study Effect Size (95% CI)
ARV treatment for prevention 96% (73-99)
PrEP for discordant couples 73% (49-85)
PrEP for heterosexual men & 63% (21-84)
women

Medical male circumcision 54% (38-66)

PrEP for MSMs 44% (15-63)

Sexually transmitted diseases 42% (21-58)
treatment

Microbicide 39% (6-60)

HIV vaccine 31% (1-51)

FEM-PrEP 0% (0-41)

0 10 20 30 40 50 60 70 80 90 100
Efficacy (%)

 Reducing HIV incidence
 Increasing access to
care and optimizing health
outcomes
 Reducing HIV-related
health disparities

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20. HIV Incidence Reduction by Prevention Technologies Study Effect Size (95% CI) ARV treatment for prevention 96% (73-99) PrEP for discordant couples 73% (49-85) PrEP for heterosexual men & 63% (21-84) women Medical male circumcision 54% (38-66) PrEP for MSMs 44% (15-63) Sexually transmitted diseases 42% (21-58) treatment Microbicide 39% (6-60) HIV vaccine 31% (1-51) FEM-PrEP 0% (0-41) 0 10 20 30 40 50 60 70 80 90 100 Efficacy (%)

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25.  Reducing HIV incidence  Increasing access to care and optimizing health outcomes  Reducing HIV-related health disparities

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