This document provides guidance on effectively communicating scientific research to different audiences. It suggests asking 5 questions to understand the audience: what is the setting of the presentation, what do they already know about the topic, where do they get their information from, what is important to them, and what preconceptions will need to be addressed. The document advises composing a biographical sketch of the target audience to answer these questions. It also notes the importance of designing presentations with the audience in mind rather than just the researcher's perspective.