Postpartum depression is a type of clinical depression that affects women, and less frequently men, after childbirth. It has a prevalence rate of 30% for women and 1-25.5% for men. There are genetic links through corticotropin-releasing factor and Hemicentin-1, which are involved in the stress response and estrogen receptor binding sites. Hormonal causes include oxytocin depletion, which plays a role in sexual reproduction and bonding during and after childbirth as well as breastfeeding. Symptoms include changes in sleep, energy, appetite, concentration, and thoughts of suicide or harming the baby due to feelings of inadequacy.