1. Postpartum DepressionPostpartum Depression

2. Postpartum DepressionPostpartum Depression
 a type of clinicala type of clinical
depression which candepression which can
affect women, andaffect women, and
less frequently men,less frequently men,
typically aftertypically after
childbirthchildbirth

3. PrevalencePrevalence
 Women 30%Women 30%
 Men 1 – 25.5%Men 1 – 25.5%

4. Genetic LinkGenetic Link
 corticotropin-corticotropin-
releasing factorreleasing factor ((CRFCRF))
 a peptide hormonea peptide hormone
and neurotransmitterand neurotransmitter
involved in the stressinvolved in the stress
responseresponse

5. Genetic LinkGenetic Link
 Hemicentin-1 (HMCN1)Hemicentin-1 (HMCN1)
 estrogen receptor-estrogen receptor-
binding sitesbinding sites

6. Hormonal CauseHormonal Cause
 Oxytocin depletionOxytocin depletion
 roles in sexualroles in sexual
reproduction, inreproduction, in
particular during andparticular during and
after childbirthafter childbirth
 Birth & maternalBirth & maternal
bondingbonding
 BreasfeedingBreasfeeding

7. SymptomsSymptoms
 Changes in sleep
 Low energy
 Appetite
 Concentration
 Thoughts of suicide
 Harming the baby (inadequacy)
 Low libido