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
 The average age of the menopause worldwide is at a median
age between 51 and 52 years.
 Endocrine changes
Physiological Menopause

 The diagnosis of menopause is a largely clinical diagnosis that
is made according to symptoms experienced.
 The use of serum endocrine tests are of little value in the
perimenopausal years as they are unpredictable due to the
hormonal variations.
Physiological Menopause

 Premature Ovarian Insufficiency
- if menopause occurs before the age of 40 years it is defined as
premature ovarian insufficiency (POI
- While no cause is found in most cases of primary POI, a
suspected case should be investigated
Non-physiological menopause

 Iatrogenic menopause – medical treatments and menopause
after cancer treatment
- Drugs that are GnRH agonists (e.g. buserelin and goserelin)
- When administered continuously will down-regulate the
pituitary and decrease LH and FSH secretion
- This will induce a temporary menopause with a relatively rapid
onset.
Non-physiological menopause

 Iatrogenic menopause – surgical menopause
- Bilateral salpingo-oophorectomy
- It is important during preparation that they are aware that as
well as losing oestrogen they will also lose the effect of
testosterone.
Non-physiological menopause

 Vasomotor symptoms
How women are affected by the
menopause

 Psychological symptoms
- depression
- low mood
- irritability
- lack of energy and tiredness
- acceleration of the onset or incidence of dementia
How women are affected by the
menopause

 Endometrial effects
- The initial irregular or scanty vaginal bleeding is due to the reduction
in estrogenic endometrial stimulation.
 The urogenital tract and vulvovaginal atrophy
- vaginal dryness, irritation, burning, soreness and dyspareunia.
- Loss of the estrogenic support to the vaginal epithelium leads to
reduced cellular turnover and reduced glandular activity
- Incontinence and prolapse worsen during the menopause
How women are affected by the
menopause

 Bone health
- There is a steady decline until the menopause, then an accelerated
phase of bone loss until 60 years, followed by further steady
decline until death
How women are affected by the
menopause

 Diet and lifestyle
Management

 pharmacological
Management

 Hormonal replacement therapy (HRT)
 If estrogen is given without progestogenic opposition, there is a risk
that in time endometrial hyperplasia and cancer may develop.
 Systemic estrogen-only HRT is suitable for women following a
hysterectomy
 The administration of progestogen is necessary to protect the
endometrium.
 This results in regular monthly menstruation.
Management

Beneficial effects of hormone
therapy


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L49 Menopause

  • 1.
  • 2.   The average age of the menopause worldwide is at a median age between 51 and 52 years.  Endocrine changes Physiological Menopause
  • 3.   The diagnosis of menopause is a largely clinical diagnosis that is made according to symptoms experienced.  The use of serum endocrine tests are of little value in the perimenopausal years as they are unpredictable due to the hormonal variations. Physiological Menopause
  • 4.   Premature Ovarian Insufficiency - if menopause occurs before the age of 40 years it is defined as premature ovarian insufficiency (POI - While no cause is found in most cases of primary POI, a suspected case should be investigated Non-physiological menopause
  • 5.   Iatrogenic menopause – medical treatments and menopause after cancer treatment - Drugs that are GnRH agonists (e.g. buserelin and goserelin) - When administered continuously will down-regulate the pituitary and decrease LH and FSH secretion - This will induce a temporary menopause with a relatively rapid onset. Non-physiological menopause
  • 6.   Iatrogenic menopause – surgical menopause - Bilateral salpingo-oophorectomy - It is important during preparation that they are aware that as well as losing oestrogen they will also lose the effect of testosterone. Non-physiological menopause
  • 7.   Vasomotor symptoms How women are affected by the menopause
  • 8.   Psychological symptoms - depression - low mood - irritability - lack of energy and tiredness - acceleration of the onset or incidence of dementia How women are affected by the menopause
  • 9.   Endometrial effects - The initial irregular or scanty vaginal bleeding is due to the reduction in estrogenic endometrial stimulation.  The urogenital tract and vulvovaginal atrophy - vaginal dryness, irritation, burning, soreness and dyspareunia. - Loss of the estrogenic support to the vaginal epithelium leads to reduced cellular turnover and reduced glandular activity - Incontinence and prolapse worsen during the menopause How women are affected by the menopause
  • 10.   Bone health - There is a steady decline until the menopause, then an accelerated phase of bone loss until 60 years, followed by further steady decline until death How women are affected by the menopause
  • 11.   Diet and lifestyle Management
  • 13.   Hormonal replacement therapy (HRT)  If estrogen is given without progestogenic opposition, there is a risk that in time endometrial hyperplasia and cancer may develop.  Systemic estrogen-only HRT is suitable for women following a hysterectomy  The administration of progestogen is necessary to protect the endometrium.  This results in regular monthly menstruation. Management
  • 14.  Beneficial effects of hormone therapy
  • 15.