2. List of content
Introduction
Metabolism
Energy systems
Processes involve into ATP production
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3. Introduction
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Defination:
A dicipline of biochemistry that focuses on
energy transformation within living
organisms.
Law of conservation of energy:
The energy can neither be created nor
destroyed-only converted from one form of
energy to another.
Energy transformation in human
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In human body, Energy is measured in
calories.
1 calori: The amount of heat required to
raise
1 gram of water by 1℃.
Chemical energy: Macro nutrients
Carbohydrate (4 Kcal/g)
Fats (9Kcal/g)
Proteins (4Kcal/g)
5. Metabolism
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Metabolism - ચયાપચય
Catabolism – Breakdown, Complex
→Simple
Anabolism – Synthesis, Simple → Complex
Human body required energy in form of
ATP for normal functioning.
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When ATP is combined with water (Hydrolysis)
the last phosphate group split away and
release energy and converted into ADP.
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Now Replenish the limited store of ATP, a
chemical reaction called phosphorylation
add a phosphate group back to ADP to
create ATP.
Energy pathways (Replenishing ATP)
Phosphorylation with O2= Aerobic
metabolism.
Phosphorylation without O2= Anaerobic
metabolism
9. Energy systems
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There are three separate energy system
through which ATP can be produced.
1) ATP PCr system
2) Anaerobic system
3) Aerobic system
10. ATP PCr system
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Atp and creatine phosphate (phospho
creatine) make up the ATP-PCr system.
ATP broken down and releasing energy and
ADP
Now ADP combine with PCr and Rebuild ATP.
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It work during first five second of excercise
with regardless of intensity. During this
time power output is greatest.
If activity continues beyond this immediate
period the body must rely on nother
energy system.
12. Anaerobic glycolysis system
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Lactic acid/ Fast glycolysis system
Lysis means Breakdown.
Anaerobic glycolysis provides energy by
the breakdown of glucose without using
oxygen.
The end product of anaerobic glycolysis is
pyruvic acid.
Because of absense of oxygen pyruvic
acid further converted into lactic acid.
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Lactic acid – Cause of Fatigue.
By about 30 seconds of sustained activity
the majority of energy comes from fast
glycolysis.
At 45 seconds of sustained activity there
is second decline in power output and
body must rely on another system to
continue activity.
15. The oxydative system
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There are four process to produce
ATP:
1) Slow glycolysis
2) Krebs cycle
3) Electron transport chain (ETC)
4) Beta oxidation
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1) Slow glycolysis
It is exactly same process as fast
glycolysis.
Metabolise glucose to form two ATPs.
Difference is that the end product pyruvic
acid is converted into acetyl coenzyme-A
rather than lactic acid.
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2) Krebs cycle
Cytricacid cycle
Acetyl coenzyme A form by slow
glycolysis is further enters into krebs
cycle.
And further chain of chemical reaction
process to form two more ATPs.
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3) Electron transport chain (ETC)
Hydrogen produced in glycolysis and
krebs cycle would cause cells to become
too acidic.
So, the hydrogen combined with two
coenzymes called NAD & FAD and it is
transported to ‘ETC’.
Here, hydrogen broken down from NAD &
FAD and combined with oxygen and form
ATP and water and prevent acidification.
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4) β Oxidation
Breakdown of fat is known as ‘lipolysis’.
Fats breakdown into fatty acid and glycerol.
This free fatty acid enters krebs cycle, They
must undergo a process of β Oxidation.
β Oxidation convert fatty acid to acetyl
coenzyme-A and hydrogen.
This byproduct further processed in krebs
cycle and ETC system to produce more ATP.