2. Introduction to Respiration
• Respiration is a fundamental cellular process that releases energy from organic
molecules, providing the necessary fuel for cellular activities. It occurs in two
main forms: aerobic and anaerobic respiration.
Importance of respiration:
Energy Production:
• Respiration is the primary mechanism for extracting energy from nutrients, such as glucose, and
converting it into a usable form, typically adenosine triphosphate (ATP).
Cellular Metabolism:
• Respiration is integral to cellular metabolism, ensuring the breakdown of complex molecules into
simpler ones and facilitating the synthesis of biomolecules necessary for cell structure and
function.
Heat Production:
• Respiration is a source of heat production in the body, contributing to temperature regulation and
helping organisms maintain an optimal internal environment.
Waste Elimination:
• Respiration is associated with the elimination of waste products, such as carbon dioxide,
generated during the breakdown of organic molecules.
3. Aerobic Respiration
• Aerobic respiration is the most efficient form of respiration that takes place in the
presence of oxygen. It involves three main stages: glycolysis, the Krebs cycle, and
the electron transport chain, occurring in the mitochondria.
• Process: Glucose, a 6-carbon molecule, is enzymatically broken down into two 3-
carbon molecules of pyruvate through a series of reactions.
• Outputs: 2 ATP (net gain), 2 NADH (energy carrier).
• Significance: Initial breakdown of glucose, occurring in the absence of oxygen.
4. Glycolysis
• Glycolysis is the first stage of aerobic respiration, occurring in the cytoplasm. It involves the
breakdown of glucose into pyruvate, producing a small amount of ATP and NADH.
1.Process:
1. Glucose (6-carbon) is enzymatically split into two molecules of pyruvate (3-carbon).
2. Requires an input of ATP to initiate the process.
2.Energy Production:
1. Yields a net gain of 2 ATP molecules.
3.Intermediate Products:
1. Produces NADH (Nicotinamide Adenine Dinucleotide), a carrier of high-energy
electrons.
4.Significance:
1. Acts as the starting point for both aerobic and anaerobic respiration pathways.
2. Occurs under both aerobic (with oxygen) and anaerobic (without oxygen) conditions.
5.Overall Role:
1. Converts glucose into a more reactive form, preparing it for further energy extraction in
subsequent stages of respiration.
5. Krebs Cycle
• The Krebs cycle, also known as the citric acid cycle, occurs in the
mitochondria. It further breaks down pyruvate, generating NADH,
FADH2, and ATP.
• Input:
• Each pyruvate from glycolysis (3-carbon molecule) is converted into acetyl-CoA
(2-carbon molecule) before entering the Krebs Cycle.
Citric Acid Formation:
• Acetyl-CoA combines with oxaloacetate (4-carbon molecule) to form citrate (6-
carbon molecule), initiating the cycle.
6. Electron Transport Chain
• The electron transport chain is the final stage of aerobic respiration,
taking place in the inner mitochondrial membrane. It utilizes
electrons from NADH and FADH2 to produce ATP and water.
7. Anaerobic Respiration
• In the absence of oxygen, cells undergo anaerobic respiration. This process
includes lactic acid fermentation and alcoholic fermentation, both providing
energy in the absence of oxygen.
Process:
Occurs during periods of intense exercise when oxygen is scarce.
Pyruvate, the end product of glycolysis, is converted into lactic acid.
Regenerates NAD+ from NADH, allowing glycolysis to continue.
Output: Lactic acid and 2 ATP molecules per glucose molecule.
Significance:
Temporary solution for energy production in the absence of oxygen.
Common in muscle cells during strenuous physical activities.
8. Lactic Acid Fermentation
• Lactic acid fermentation occurs in muscle cells during intense
exercise. Pyruvate is converted into lactic acid, regenerating NAD+
and allowing glycolysis to continue.
• Process:
• Begins with glycolysis, where one molecule of glucose is broken down into two
molecules of pyruvate.
• In the absence of oxygen, pyruvate is converted into lactic acid through a series of
enzymatic reactions.
• The conversion of pyruvate to lactic acid is a means of regenerating NAD+ from
NADH, ensuring the continuation of glycolysis.
• Output:
• Lactic acid is the end product.
• Produces a net gain of 2 ATP molecules per glucose molecule.
9. Alcoholic Fermentation
• Alcoholic fermentation is common in yeast and some bacteria. It converts
pyruvate into ethanol and carbon dioxide, producing ATP and regenerating NAD+
for glycolysis.
1.Process:
1. Begins with glycolysis, breaking down one molecule of glucose into two
molecules of pyruvate.
2. In the absence of oxygen, pyruvate is further metabolized into ethanol and
carbon dioxide.
3. This process regenerates NAD+ from NADH, ensuring the continuation of
glycolysis.
2.Output:
1. Ethanol (alcohol) and carbon dioxide are the final products.
2. Produces a net gain of 2 ATP molecules per glucose molecule.
10. Conclusion
• Respiration, whether aerobic or anaerobic, is a crucial process that
sustains life by converting nutrients into usable energy.
Understanding the intricacies of respiration provides insights into the
energy dynamics within cells and their adaptability to varying
environmental conditions.