1. The document describes the histological structure of the cerebellum including its three layers - molecular layer, Purkinje cell layer, and granular layer.
2. It lists the afferent and efferent nerve fibers of the three cerebellar peduncles - superior, middle, and inferior. The superior cerebellar peduncle has dentato-rubral tract and dentatothalamic tract as efferents.
3. The physiological functions of the three divisions of the cerebellum are described. The spinocerebellum regulates muscle tone and posture. The cerebrocerebellum is involved in skilled movement and cognitive functions. The vestibulocerebellum
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Describe the histological structure of cerebellum
List afferent and efferent nerve fibres of cerebellar peduncle
Describe the physiological function of each cerebellum division
Discuss pharmacological effect, side effects and drug
interaction of tetrahydrocannibinol
4 Discuss lesion of cerebellum according to the
anatomical division
5 Discuss the effects of ethanol on central nervous system
8. • Two types of neurons:
(stellate cells & basket cells)
• Neurolgia cells
• Dendrites of Purkinje cells
• Axons of granular cells
Molecular layer
9. Purkinje cell layer
• Large pyriform cells arranged in
a single layer (Golgi type I
neuron)
• Their dendrites synapse with
axons of granular cells & relay
with axons of the collateral
branches of basket cells
10. Granular layer
Granular cells & Neurolgia
Axons of granular cells synapse
with dendrites of Purkinje cells.
Dendrites of granular cells synapse
with mossy fibers.
11. • Climbing fibers: synapse with Purkinje
cells.
• Mossy fibers: terminate by multiple
branches around the dendrites of the
granular cells.
• Efferent fibers: Axons of Purkinje cells
•. Intrinsic fibers: which connect different
parts of the cerebellum.
The cerebellar white matter
12.
13.
14. Which layer of cerebellar cortex contains the axons of
granule cells?
A. Cerebellar white matter
B. Purkinje cell layer
C.
D. Granule cell layer
E .C&D
Molecular layer
15. List afferent and efferent nerve
fibres of cerebellar peduncle
Presented by : malak benghazi
48. • Planning & programming of movements
• Learning of new movements
• Planning & execution of skilled movements
• cognitive functions)
• Balistic movement
71. the effects of ethanol on
central nervous system
Presented by : zeizi ahmed
72. • The CNS is markedly affected by
acute alcohol consumption.
• Alcohol causes sedation, relief of
anxiety and, at higher
concentrations, slurred speech,
ataxia, impaired judgment, and
disinhibited behavior, a condition
usually called intoxication or
drunkenness.
Ethanol
73. The main acute cellular effects of ethanol that
occur at concentrations (5–100 mmol/l)
relevant to alcohol consumption by humans
are:
Enhancement of γ-aminobutyric acid type-A
(GABAA)
74. Inhibition of ionotropic glutamate receptor
function
“Blackouts” periods of memory loss
that occur with high levels of alcohol
may result from inhibition of NMDA
receptor activation.
NMDA
75. “Blackouts” periods of memory loss that occur with
high levels of alcohol may result from enhancement
of GABA type A receptors
A.True B.False
77. • a powerful psychoactive
substance , THC causes
disinhibition of dopamine
neurons, mainly by
presynaptic inhibition of
GABA neurons in the VTA.
Δ9-tetra-hydrocannabinol (THC)
78. • Cannabinoid receptors in brain
termed CB1 receptors to
distinguish them from the CB2
receptors subsequently identified
in peripheral tissues. Cannabinoid
receptors are typical members of
the family of G protein-coupled
receptors.
79. • Impairment of short-term memory and simple learning tasks -subjective
feelings of confidence and heightened creativity are not reflected in actual
performance
• Impairment of motor coordination (e.g. driving performance)
• Catalepsy the adoption of fixed unnatural postures
• Hypothermia
• Analgesia
• Antiemetic action
• Increased appetite
Central effects