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Antidiuretic hormone and the mineralcorticoids
Antidiuretic Hormone: ADH   ,[object Object]
Synthesis of ADH   ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],Synthesis of ADH
Secretion of ADH ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],Secretion of ADH
Pathway by which ADH secretion is lowered and water exrection raised when excess water is ingested
[object Object],[object Object],[object Object],[object Object],Secretion of ADH
[object Object],[object Object],[object Object],[object Object],Secretion of ADH
Pathway by which ADH secretion and tubular permeability to water is increased when plasma volume decreases
[object Object],[object Object],[object Object],[object Object],Secretion of ADH
Hypothalamus, posterior pituitary and ADH secretion– connection with baroreceptors
[object Object],[object Object],[object Object],[object Object],Secretion of ADH
[object Object],[object Object],[object Object],Secretion of ADH
Osmotic and hemodynamic control of ADH secretion– changes in osmolality; changes in blood volume or pressure; interactions between osmolar  and volume/pressure stimuli on ADH secretion.
Actions of ADH ,[object Object],[object Object],[object Object],[object Object],[object Object]
Actions of ADH ,[object Object],[object Object],[object Object]
Actions of ADH ,[object Object],[object Object]
[object Object],Actions of ADH
Inputs reflexly controlling thirst.
[object Object],[object Object],Actions of ADH
Pathways by which sodium and water excretion are decreased in response to severe sweating.
Aldosterone and the mineralocorticoids   ,[object Object],[object Object]
Cross section through the adrenal gland– cortex and medulla  salt sugar sex
Aldosterone ,[object Object],[object Object]
[object Object],[object Object],Adrenal zones
[object Object],[object Object],Adrenal zones
[object Object],[object Object],[object Object],Aldosterone synthesis
Aldosterone synthesis  in the adrenal  zona glomerulosa
[object Object],[object Object],[object Object],Aldosterone’s function
Regulation of aldosterone secretion: Activation of renin-angiotensin system in response to hypovolemia is predominant stimulus for aldosterone synthesis.
[object Object],Aldosterone and renin-angII
[object Object],[object Object],Aldosterone
Components of renin-angiotensin-aldosterone system
[object Object],[object Object],[object Object],[object Object],Aldosterone
Aldosterone clears potassium ,[object Object],[object Object],[object Object]
[object Object],[object Object],Aldosterone synthesis
Aldosterone synthesis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Aldosterone action ,[object Object],[object Object]
Model for basic renal handling of potassium. Net absorption occurs in the proximal portions of the nephron and net secretion in the more distal portions of the nephron.
Action of aldosterone on the renal tubule.  Sodium reabsorption from tubular urine into the tubular cells is stimulated. At the same time, potassium secretion from the tubular cell into urine is increased. Na + /K + -ATPase, and Na +  channels work together to increase volume and pressure, and decrease K + .
Aldosterone action ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],Aldosterone action
Pathway by which an increased potassium intake induces greater potassium excretion mediated by aldosterone
Pathway by which aldosterone sercretion and tubular sodium reabsorption is increased when plasma volume is decreased
[object Object],[object Object],Aldosterone action
Cortisol is at 1000 fold higher concentrations than aldosterone
[object Object],[object Object],[object Object],Aldosterone action
Summary of aldosterone system

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Adh

  • 1. Antidiuretic hormone and the mineralcorticoids
  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7. Pathway by which ADH secretion is lowered and water exrection raised when excess water is ingested
  • 8.
  • 9.
  • 10. Pathway by which ADH secretion and tubular permeability to water is increased when plasma volume decreases
  • 11.
  • 12. Hypothalamus, posterior pituitary and ADH secretion– connection with baroreceptors
  • 13.
  • 14.
  • 15. Osmotic and hemodynamic control of ADH secretion– changes in osmolality; changes in blood volume or pressure; interactions between osmolar and volume/pressure stimuli on ADH secretion.
  • 16.
  • 17.
  • 18.
  • 19.
  • 21.
  • 22. Pathways by which sodium and water excretion are decreased in response to severe sweating.
  • 23.
  • 24. Cross section through the adrenal gland– cortex and medulla salt sugar sex
  • 25.
  • 26.
  • 27.
  • 28.
  • 29. Aldosterone synthesis in the adrenal zona glomerulosa
  • 30.
  • 31. Regulation of aldosterone secretion: Activation of renin-angiotensin system in response to hypovolemia is predominant stimulus for aldosterone synthesis.
  • 32.
  • 33.
  • 35.
  • 36.
  • 37.
  • 38.
  • 39.
  • 40. Model for basic renal handling of potassium. Net absorption occurs in the proximal portions of the nephron and net secretion in the more distal portions of the nephron.
  • 41. Action of aldosterone on the renal tubule. Sodium reabsorption from tubular urine into the tubular cells is stimulated. At the same time, potassium secretion from the tubular cell into urine is increased. Na + /K + -ATPase, and Na + channels work together to increase volume and pressure, and decrease K + .
  • 42.
  • 43.
  • 44. Pathway by which an increased potassium intake induces greater potassium excretion mediated by aldosterone
  • 45. Pathway by which aldosterone sercretion and tubular sodium reabsorption is increased when plasma volume is decreased
  • 46.
  • 47. Cortisol is at 1000 fold higher concentrations than aldosterone
  • 48.