Clarithromycin is used to treat a wide variety of bacterial infections. This medication can also be used in combination with anti-ulcer medications to treat certain types of stomach ulcers. It may also be used to prevent certain bacterial infections. Clarithromycin is known as a macrolide antibiotic. It works by stopping the growth of bacteria. This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.

1. Prepared By
Md. Sakhaoat Hossain

2. Clarithromycin is a macrolide antibiotic that gives antibacterial activity by
inhibiting the protein synthesis of bacterial cell. It is usually bacteriostatic,
but may be bactericidal depending on the organism and drug
concentration.
Clarithromycin

3. Absorption: Plasma Half-Life: 2.9-9.2 Hours
Plasma protein binding: 80%
Bioavailability: 50% after oral administration
Metabolism: Hepatic Excretion: Renal 37% & Hepatic
Pharmacokinetics
Pharmacodynamics
Clarithromycin is a broad spectrum antibiotic that has activity
against Gram positive & Gram negative aerobic bacteria, some
anaerobic bacteria, some mycobacteria, microorganisms and of
course Helicobacter pylori.

4. Pathophysiology of bacteria
 Created biofilm that protects them
from hosts immune system and some
commonly used antibiotics.
Mechanism of Clarithromycin
 Inhibits the production of glycolax and thus
penetrates the biofilm.
 Increases the activities of concomitantly
used bacterial agents
 Stimulates the phagocytic activity of leucocytes.
 Inhibits the expression of cytokines
Mode of action

5.  Respiratory Tract Infection
 Skin & Soft Tissue Infection
 Mycobacterium avium infections
 Gastric & Duodenal Ulcers
 Eradication of H. pylori
Clinical Uses

6. Can not use with these type of drugs
Statins
Ca Channel blockers
Anti-HIV Drugs
Carbamazepine
PDE-5 inhibitors
Rifampicin
Drug Interactions

7. Bangladesh market of
Clarithromycin
Brand Name Company
name
Market
share
Growth
Klabid Unimed &
Unihealth
15.44% 61.75%
Helicon Kit General 12.75% -0.31%
Binodar Acme 10.63% 23.11%
Pylotrip Sandoz 9.83% -17.44%

8. 1. https://www.drugs.com/dosage/clarithromycin.html
2. Goodman and Gilman's The Pharmacological Basis of Therapeutics,
13th Edition
3. An Introduction to Medicinal Chemistry 3rd Edition by Graham L.
Patrick
4. https://medlineplus.gov/druginfo/meds/a692005.html
5. IMS data August 2019
References: