Antacid Analysis

1. VIDYABHARTI COLLEGE OF PHARMACY, AMARAVATI 444602,
2019-2020

2. INDEX
1. INTRODUCTION
2. IDEAL CHARECTERISTICS
3. MECHANISM
4. TYPES OF ANTACID
5. USES
6. CASE STUDY
7. RESULT & CONCLUSION
8. REFRENCES
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3. Introduction
An Antacid is any substance , generally a base or
basic salt, which neutralizes stomach acidity.
They are used to relive acid indigestion, upset
stomach ,sour stomach and heartburn
Some An Antacid are a class (group) of medicine
which help to neutralized the acid content of your
stomach An Antacid : Aluminum Hydroxide.
Sodium Carbonate
This comes in various different brand name and
are available as tablets liquids
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9. CALCIUM CARBONATE
 Calcium carbonate is widely available at natural
inorganic compound , also known as chalk limestone
 Calcite is most stable polymorph of calcium carbonate.
it is transparent to opaque
 Carbonate is found frequently in geologic setting and
constitutes an enormous carbon reservoir.
 It occurs as aragonite , calcite and dolomite as
significant constituents of calcium cycle.
 Calcium carbonate is mainly used in construction
industry, as a calcium supplement for gastric antacid.
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10. STRUCTURE
HO
Ca
O
OH
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11. Quantative analysis of calcium carbonate
Abstract
 Fourier Transform Infrared Spectroscopy (FT-IR) was used
successfully for the simultaneous quantitative analysis of
 calcium carbonate phases (calcite, aragonite, vaterite) in ternary
mixtures. From the FT-IR spectra of pure calcite,
 aragonite and vaterite powders with KBr, the absorptivities, a, of
the absorption bands at 713 cm1 for calcite, 745
 cm1 for vaterite, 713 and 700 cm1 for aragonite, were determined.
In order to overcome the absorption band
 overlapping a set of equations based on Beer’s law was
developed. The detection limits were also established and found
 to be 1.1/104 mg calcite per mm2 of pellet at 713 cm1, 3.6/104 mg
aragonite per mm2 of pellet at 700 cm1,
 Keywords: FT-IR; Calcite; Aragonite; Vaterite; Quantitative
analysis; Synthetic calcium carbonate
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CASE STUDY

12.  The speciation of carbonate-bicarbonate in aquatics
systems
 A fundamental process that has been studied extensively
recently Alice et al.
 Reported the hydration behavior of CO Using Near Edge X-
ray Absorption Fine Energy Spectroscopy.
 Oliver and Davis observed that in an aqueous system about
10%of the
 Bicarbonate decomposed to carbon dioxide and carbonate
at 25 8C according to following equation
 2 HCO CO2+CO32-
Introduction
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13. Experimental
Instrumentation
 All spectra were recorded from 4000/400 cm1,
using the EQUINOX 55 (Brucker) FT-IR spectrometer.
 The IR spectra were recorded and stored using a
spectroscopicsoftware (OPUS, Version 2.0).
 The crystal size was measured by using the
Mastersizer S (Malvern Instruments, England).
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14. Reagents
 ammonium carbonate
 calcium nitrate
 sodium carbonate
 potassium nitrate
 sodium hydrogen carbonate
 standard sodium hydroxide
 Purified water
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INSTRUMENTATION

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17. Results and discussion
 The selection of the appropriate bands for the
quantitative analysis was a difficult task since
there is a strong overlapping. The absorption
bands chosen for the quantitative analysis of a
ternary mixture were the 713 cm1 for calcite, the
700 and 713 cm1 for aragonite, and the 745 cm1 for
vaterite.
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19. Conclusions
 A new methodology, based on the use of FT-IR, was used
successfully for the simultaneous quantitative
determination of anhydrous calcium carbonates crystal
phases.
 The absorptivities for the absorption bands of the
polymorphs used in the analytical technique were
established and the respected detection limits were
determined.
 The proposed methodology allows a direct simultaneous
quantitative determination of calcium carbonates phases as
opposed to Raman spectroscopy where only relative ratios
can be determined.
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20. Thank you!
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