Pharmaceutical Inorganic Chemistry, B.Pharmacy I year I semester Subject

1. Gastrointestinal agents
Mrs.Dipali M.Kulkarni,
Assistant Professor,
Yash Institute of Pharmacy,
Aurangabad.

2. Gastrointestinal agents
Acidifiers:
Ammonium chloride*
Dil. HCl Antacid:
Ideal properties of antacids,
combinations of antacids,
Sodium 40 Bicarbonate*,
Aluminum hydroxide gel,
Magnesium hydroxide mixture
Cathartics:
Magnesium sulphate,
Sodium orthophosphate,
Kaolin
Bentonite

3. Gastro intestinal agents
Product
altering
gastric
pH
Acidifiers
Antacid
2. Protectives for
intestinal
inflammation
3.
Adsorbent
for
intestinal
toxins
4. Cathartics
and Laxatives
Inorganic agents used to treat gastrointestinal disorder

4. ACIDIFERS
Patients suffering from ,hypochlorhydria or
achlorhydria, there is less or absence of hydrochloric
acid in Gastric secretions.
In such cases, acidifiers are useful in providing the
necessary acidity for the proper digestion of food.
Systemic acidifiers are those which, when gives usually
by injection, act by reducing the alkali reserve in the
body and so are useful in reducing metabolic alkalosis.
Ammonium chloride, Calcium chloride, Dilute HCl

5. AMMONIUM CHLORIDE
Category: Systemic acidifier, expectorant and diuretic
Description: Hygroscopic white crystalline powder.
Solubility: Soluble in water, alcohol & glycerine
•NH4Cl act by stimulating the gastric reflexes
(causing irritation by ammonia/amine gas)
HCl → H+ + Cl-
NH4Cl → NH3 + HCl

6. Method of preparation of Ammonium Chloride
• Preparation:
• Ammonium chloride is made by reacting hydrochloric
acid with ammonia the solution is evaporated to
dryness and the product is purified by recrystallization.
NH3 + HCl → NH4Cl
• Doses: it is given 3- 6 g per day in divided doses.

7. Indicator- ferric
ammonium sulphate
A solution acidifies
with nitric acid
shake with a
measured volume
of N/10 silver
nitrate,
Nitrobenzene added
It coagulate silver
chloride PPT, avoid its
interference
Titrate with excess
of silver nitrate
N/10 ammonium
thiocynate,.
Assay of ammonium chloride
A modified Volhard method I.P

8. AgNO3 + NH4Cl → AgCl + NH4NO3
AgNO3 + NH4SCN → AgSCN + NH4NO3
Ammonium thiocynate Silver thiocynate
• The following is the reaction taking place at the end point when
red ferric thiocynate is formed (by reaction of ammonium
thiocynate with the indicator ammonium sulphate).
FeNH4(SO4)2 +3NH4SCN → Fe(SCN)3 + 2(NH4)2SO4

9. It is colour less
aqueous solution
acidic to litmus.
Prepared by mixing
274gm of HCl and 726
gmof purified water
(Ref. I.P.).
I.P. Limit: It contains
not less than 9.5%
and not more than
10.5% w/w of HCl.
When 5.0ml of dilute
HCl is added to 200ml
ofwater, it provides
about 15 mEq of dil.
HCl acid
Dilute HCl I.P.
Recommended to relieve the patients suffering from achlorhydria

10. Method of Analysis: Dil HCl
• It is analyzed on the principle of ‘acid-base titration’.
• An accurately weighed quantity (4.0g to 6.0g),
add 30 ml of distilled water mix , titrate against 1.0 N NaOH
Indicator - methyl orange
HCl + NaOH → NaCl + H2O
Each ml of 1.0 N NaOH solution is equivalent 0.03646g of HCl

11. Test for Identification:
1) When added to KMnO4 with
dilute nitric acid,chlorine is evolved.
2) Limit test for chloride: To
acidified solution add silver nitrate
solution, shake and allow to stand,
curdy white precipitate is formed,
which is insoluble in HNO3,
but this ppt soluble after being
washed with water in ammonium
hydroxide
from which it is re-precipitated by
the additionof HNO3.

12. Dose & Uses
• Dose:
About 0.6 to
8.0 ml
• The acid should be
diluted with 25-50
volumes with water or
juice and sipped
through a glass tube to
prevent reaction upon
dental enamel.
It is taken during or
after meals given
inconjunction with
iron therapy in
hyperchromic
anemia.
• Uses:
Acidifier

13. Antacids are weak
bases
• Raise pH to about
4- 7 (NaHCO3)
without systemic
alkalosis
Decrease gastric
acidity by
neutralizing HCL.
Used in
hyperchlorhydria to
relieve pain (HCH)
• Effectiveness of
antacids is measured in
neutralizing capacity.
• HCl secreted by
epithelial cell of gastric
mucosa, PH of stomach -
1-6.
• Gastritis
inflammation of gastric
mucosa
hypersecretion of HCL.
• Prolong excessive
secretion of HCl-
peptic ulcer.
• Mucosal layer Erosion-
Esophageal ulcer, gastric
ulcer, duodenal ulcer
Antacids

14. Ideal Characteristic of Antacid
should
not be
absorba
ble,
causes
systemic
alkalosis
should
not be
laxative
or cause
constipat
ion
should
exert
effect
rapidly,
over a
long
period of
time
should
buffer in
pH 4-6.
should
not
produce
large
volume
of gas
should
be
palatable
,
inexpens
ive
should
probably
inhibit
pepsin

15. Antacids are divided into two categories
1.Systemic/Absorbable Antacids, alkalotic agents, systemic alkalisers
absorbs from gut into blood circulation, changes pH of the blood and
cause systemic alkalosis.
in diabetic coma-used by injection to relieve acidosis in the blood.
Sodium bicarbonate, Potassium citrate, Sodium citrate
Side-effects: Nausea, Vomiting, Diarrhea, Abdominal pain, Headache,
Irritability, Insomnia etc
Uses: use to combat/maintain acidosis systemic acidbase balance (acid-
base equilibrium) of the blood
CLASSFICATION OF ANTACIDS

16. 2.Non-systemic Antacids: local antacids
Neutralize acid in stomach, relives gastric and duodenal ulcers.
a) Aluminium hydroxide gel
B) Dried aluminium hydroxide gel
c) Aluminium phosphate
d) Magnesium hydroxide
e) Magnesium trisilicate
f) Light and heavy magnesium carbonate
g) Magaldrate
h) Calcium carbonate.
i)Bismulth suberarbonate.

17. • Insoluble in water
• Absorption rate is less due to their cationic nature
• No direct effect upon the systemic acid base
Balance (acid-base equilibrium) of the blood
• E.g. Aluminum hydroxide and Magnesium hydroxide & Mg trisilicate
• Uses: in the treatment of peptic ulcer & hyperacidity
Properties of non systemic antacids

18. Thank you