Physical incompatibility occurs when two or more substances are combined and a physical change takes place, such as immiscibility, insolubility, or precipitation. Chemical incompatibility happens when agents react chemically when mixed, through processes like oxidation, reduction, acid-base reactions, hydrolysis, or combination reactions. Therapeutic incompatibility is when certain drugs are prescribed with the intention of a specific effect, but a different effect is produced, potentially due to overdose, improper dosage, contraindicated drugs, or synergistic/antagonistic interactions.

1. Presented by
Monia Jannatul Kubra
BKH1604036F
Group: 06

2. 2
Pharmaceutical incompatibility:
Prescribing or mixing of substances which are
antagonistic in nature and an undesirable product is
formed which may affect the safety, purpose, efficacy and
appearance of the preparation.
!
Milk Tetracycline
hydrocloride

3. 3
Pharmaceutical
Incompatibilitie
s
Physical
Incompatibility
Chemical
Incompatibility
Therapeutic
Incompatibility
Tolerated
Adjusted

4. 4
Physical incompatibility
When two or more than two substances are
combined together, physical change takes place and
produce a preparation in appearance or inaccuracy in
dosage or immiscibility problems.
Olive oil Water Oil
immiscible
with water
Due to:
• Immiscibility
• Insolubility
• Precipitate formation
• liquefaction

5. 5
Menthol 5 gm
Camphor 5 gm
Ammonium chloride 30 gm
Light magnesium carbonate 60 gm
Make an insufflation.
Type: Physical Incompatibility

6. 6
Chemical Incompatibility
When agents are prescribed that react chemically when
mixed, altering the composition of one or more of
constituents.
Result From:
1. Oxidation Reduction 2. Acid-base reaction
3. Hydrolysis 4.Combination reaction
Tolerated:
Interaction is minimized where
practicable but no alteration is
made in the composition of the
preparation.
Adjusted:
Interaction is prevented by
some addition or substitution
which does not affect the
medical action of drug.

7. 7
Sodium salicylate 5 gm
Syrup of lemon 20 ml
Water up to 75ml
Make a mixture.
Type: Chemical Incompatibility
Sodium salicylate Citric Acid Salicylic Acid
Sodium salicylate 5 gm
Simple syrup 19 ml
Tincture of lemon 1.2 ml
Water up to 75ml
Make a mixture.

8. 8
Therapeutic Incompatibility
Prescribe of certain drugs to the patient with the
intention to produce a specific degree of action but
the nature or the intensity of the action produced is
different from that intended by the prescriber.
Due to
• Overdose or improper dose of a single dose
• Wrong dose or dosage form
• Contraindicated drug
• Synergistic and antagonistic drugs

9. 9
I think it says…..
Take 2 capsules
300 times…..A day….
Or something

10. 10
Tetracycline hydrochloride 250gm
Make capsules. Send such 10 capsules.
Label : Take one capsule every six hours with milk
Type: Therapeutic Incompatibility
!
Milk Tetracycline
hydrocloride

11. 11