BUCCAL DRUG DELIVERY SYSTEM

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DRUG DELIVERY SYSTEM
BUCCAL DRUG DELIVERY SYSTEM
R R COLLEGE OF PHARMACY
Submitted by: Submitted to:
Pushpa Sahani Dr.A Geetha Lakshmi
1st Sem M PHARM . Prof and HOD of pharmaceutices

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Contents
1.Introduction of BDDS
2.Principle of BDDS
3.Advantages of BDDS
4.Disadvantages of BDDS
5.Limitation and uses of BDDS.

3. Introduction
• Buccal delivery, consist of administration through the buccal
mucosa, which is mainly composed of the lining of the cheeks.
• The buccal formulation are placed between the higher
gingiva(gum) and cheeks to provide local and systemic effects.
• The buccal route provides potential routes for hydrophilic,
unstable proteins and polysaccharides.
• Additionally ,buccal drug delivery has highly patient
acceptability compared to other non-oral routes of drug
administration.
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4. Anatomy/Physiology of Buccal Cavity
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5. • The oral mucosa is composed of an outer most layer of stratified
squamous epithelium(about40-50layers thick),as the innermost layer.
• The mucosa of the gingival and hard palate are keratinized similar to
the epidermis contain neutral lipids like ceramides and acylcermides
which are relatively impermeable to water.
• The mucosa of the soft palate, the sublingual and the buccal regions,
however are nonkeratinized contain only small amounts of ceramides.
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6. Mucin Chemistry
• The pH of saliva is due to Mucin (6.2-7.4).
• Mucins are synthesized by the goblet cells and special exocrine
glands & secreted by sialic cells & Mucus cells
• It is gylcorylated glycoprotein having large peptide backbone &
oligosaccharides side chains
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7. Principle of Mucoadhesion
• The term ‘mucoadhesive’ is commonly used for materials that bind
to the mucin layer of a biological membrane.
&
• Achieve systemic delivery of drugs include tablets,(miconazole)
patches( gasofilm oral disintegrating) films,(onsolin)
Semisolids(curenext oral gel) and powders(polyethylene glycil 3350
powder for oral solution).
• The main principle involved in this are MUCO and ADHESIVE
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8. MUCO
• Inner layers called mucosa.
• Inner epithelial cell lining is covered with viscoelastic fluid.
• Secreted by globlet cells.
• Composed of water and mucin.
• Other component include proteins, lipids, mucopolysaccarides,
electrolytes
• Thickness varies from 40-50µm to ͌300µm
• Main role is protective and lubricants
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10. ADHESIVE
• Tendency of substance to remain adhered to surface
• If substance adhere to biological membrane it is called as Bio adhesion
• If substance adhere to biological mucosal layers it is called as
mucoadhesion
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11. Drug Delivery Pathways
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Two possible routes of drug absorption through
oral mucosa

12. Environment Of Buccal Mucosa
1. The cells of the oral epithelia are surrounded by an intercellular
ground substance, mucus.
2. The oral cavity is marked by the presence of saliva produced by the
salivary glands.
3. Mucus which is secreted by the major and minor salivary glands as
part of saliva .
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13. • Role of Saliva•
Continuous mineralization / demineralization of the tooth enamel
Protective fluid for all tissues of the oral cavity
To hydrate oral mucosal dosage forms
• Role of Mucus•
Bioadhesion of mucoadhesive drug delivery systems made up of
proteins and carbohydrates
Cell-cell adhesion
Lubrication
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14. Advantages Of Buccal Drug Delivery Systems
1. Ease of administration.
2. Termination of therapy is easy.
3. Permits localization of drug to the oral cavity for a prolonged period
of time.
4. Can be administered to unconscious patients.
5. Offers an excellent route, for the systemic delivery of drugs with high
first pass metabolism, thereby offering a greater bioavailability.
6. A significant reduction in dose can be achieved there by reducing
dose related side effects.
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15. 7 Drugs which are unstable in the acidic environment are destroyed
by enzymatic or alkaline environment of intestine can be administered by
this route.
8 Drugs which show poor bioavailability via the oral route can be
administered conveniently.
9 The presence of saliva ensures relatively large amount of water for
drug dissolution unlike in case of rectal and transdermal routes.
10 This route provides an alternative for the administration of various
hormones, narcotic, analgesic, steroids, enzymes, and cardiovascular
agents etc.
11 The buccal mucosa is highly perfused with blood vessels and offers a
greater permeability than the skin.
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16. Disadvantages
1. Drugs, which irritate the oral mucosa, have a bitter or unpleasant
taste, odour; can not be administered by this route.
2. Drugs, which are unstable at buccal pH can not be administered
by this route.
3. Only drugs with small dose requirements can be administered.
4. Drugs may swallow with saliva and loses the advantages of buccal
route.
5. Only those drugs, which are absorbed by passive diffusion can be
administered by this route.
6. Eating and drinking may become restricted
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17. Limitations:
• The mucus is constantly removed from the epithelial
surfaces. It will eventually wash out the dosage form from the
site of application.
• The mucous turn over rate is different from person to person
so fabrication of the dosage form is difficult.
• The adhesion rate of dosage form in the body may not be as
per proposed specification due to disease state, different
physiological factors, etc.
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18. • The good mucoadhesive polymers that will fulfill all the requirements
are less.
• Mucoadhesive polymers are poly electrolytes.
• This type of drug delivery system is not suitable for drugs that causes
tissue irritation
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19. Uses of Buccal Delivery
• The oral cavity can be used for local and systemic therapy.
• Examples of local therapy would be the treatment of oral infections ,
dental caries, mouth ulcers, stomatitis , gingivitis etc.
• The buccal route is of particular interest with regard to the systemic
delivery of small molecules that are subjected to first-pass metabolism
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20. REFERENCE
1. buccal drug ds.pdf
2. https://www.slideshare.net/sarankumardas/buccal-drug-delivery-
system-122625402
3. Novel drug delivery system 7th semester book .
4. Jain N K, “Controlled and Novel Drug Delivery Systems”, 1st edi,
2009 reprint, CBS publishers, New Delhi
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