NSAID'S describe definition, classification and drugs related to NSAID'S category such as Aspirin, Paracetamol and Ibuprofen

1. NSAID
Prepared & presented By
Priyanka Deshmukh
K.Y.D.S.C.T.’s college of pharmacy, Sakegaon

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Medication that are used
to relieve pain, reduce
inflammation and also
lower the elevated B.P
Defination 1. Salicyclic acid derivative-
Aspirin.
2. N-acetyl anthranilic acid
derivative- Mefanamic acid.
3. Aryl acetic acid derivative-
Indomethacin, Ibuprofen
4. Pyrazole derivative
a) 5- pyrazolene deivatives-
Analgin
b) Pyrazolidine-3,5-dione-
Phenylbutazone
5. Preferential coX-2 inhibitors-
Nimesulide.
CLASSIFICATION

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No.4Aspirin
Also called as Acetyl Salicyclic Acid
 Chemical Name:
2-acetoxy benzoic acid
 Mol. Wt. 180.2
 Physical properties
1. Colourless crystals or white
crystalline powder
2. Odourless
3. Has slightly bitter taste
4. Slightly soluble in water
5. Freely soluble in alcohol
 Dose
0.5-0.2g per day
 Brand Names
 Aspro
 Anacin
 Coldarin
 powerin

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 Pharmaceutical formulation
1. Aspirin Tablets
2. Aspirin soluble tablets
3. Aspirin And caffeine tablets
4. Aspirin Gastro resistent tablet
 Stability and storage
1. Stable in air.But slowly hydrolysed
in presence of moisture.
2. Hence it is stored in well-
closed containers.
 Uses
1. For relief of mild to moderate
pain like headache, toothache,
myalgia.
2. As an antipyretic.
3. To treat gout.
4. In high doses, to reduce risk of
myocardial infarction

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No.8 Paracetamol
Also called as acetaminophen
 Chemical name
N-acetyl, p-aminophenol
 Mol.wt 151.2
Physical properties
1. White crystals or white
crystalline powder.
2. Odourless .
3. Has bitter taste.
4. Sparingly soluble in water
5. soluble in alcohol

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Storage
1. Stored in well close, light-
resistent container.
2. Protected from moisture.
Uses
1. For relief of mild to moderate
pain like headache,toothache
2. As an antipyretic
 Dose
325-625 mg times a day
 Brand name
1. Crocin
2. Calpol
3. Paramol
4. metacin
Pharmaceutical formulation
1. Paracetamol Tablets
2. Paracetamol Infusion
3. Paracetamol Elixir
4. Paracetamol Paediatric
syrup
5. Paracetamol Oral
suspension

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No.12Ibuprofen
Chemical name
(RS)-2-(4-isobutyl phenyl
)propionic acid
Mol.wt. 206.3
Properties
1. White crystals or white
crystalline powder
2. Characteristic odour
3. Soluble in aqueous solution
of alkali
4. Freely soluble in alcohol
5. Very slightly soluble in water
 Storage
Well closed container
 Uses
Relief pain from various
condition such as headache,
muscle pain
 Dose
400-600mg TDS
Brand name
1. Brufen
2. Ibugesic
3. Emflam