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INTRODUCTION
TO
BIOPHARMACEUTICS CLASSIFICATION
SYSTEM
Prepared & presented by
Priyanka Deshmukh
INTRODUCTION
 The Biopharmaceutics Classification System is a
system to differentiate the drugs on the basis of their
solubility and permeability.
 This concept was first developed by Dr. Gordon
Amidon and his colleagues in 1995.
Classification of drugs as per BCS system
High solubility and High permeability
Low solubility and High permeability
High solubility and Low permeability
Low solubility and Low permeability
I
II
III
IV
High solubility and High permeability
 Those compounds are well absorbed and their
absorption rate is usually higher than excretion.
 Example: Metoprolol
Paracetamol
Low solubility and High permeability
 Bioavailability of those products is limited by their
solvation rate.
 A correlation between the in vivo bioavailability and in
vitro solvation can be found.
 Example: Aceclofenac
Glibenclamide
High solubility and Low permeability
 The absorption is limited by the permeation rate but the
drug is solvated very fast.
 If the formulation does not change the permeability or
gastro- intestinal duration time, then class I criteria can be
applied.
 Example: Climetidine
Low solubility and Low permeability
 Those compounds have a poor bioavailability.
 Usually they are not well absorbed over the intestinal
mucosa and a high variability is expected.
 Example: Bifonazole.
CREDITS: This presentation template was created by Slidesgo, and
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and content by Swetha Tandri
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INTRODUCTION TO BIOPHARMACEUTICS CLASSIFICATION SYSTEM

  • 2. INTRODUCTION  The Biopharmaceutics Classification System is a system to differentiate the drugs on the basis of their solubility and permeability.  This concept was first developed by Dr. Gordon Amidon and his colleagues in 1995.
  • 3. Classification of drugs as per BCS system High solubility and High permeability Low solubility and High permeability High solubility and Low permeability Low solubility and Low permeability I II III IV
  • 4. High solubility and High permeability  Those compounds are well absorbed and their absorption rate is usually higher than excretion.  Example: Metoprolol Paracetamol
  • 5. Low solubility and High permeability  Bioavailability of those products is limited by their solvation rate.  A correlation between the in vivo bioavailability and in vitro solvation can be found.  Example: Aceclofenac Glibenclamide
  • 6. High solubility and Low permeability  The absorption is limited by the permeation rate but the drug is solvated very fast.  If the formulation does not change the permeability or gastro- intestinal duration time, then class I criteria can be applied.  Example: Climetidine
  • 7. Low solubility and Low permeability  Those compounds have a poor bioavailability.  Usually they are not well absorbed over the intestinal mucosa and a high variability is expected.  Example: Bifonazole.
  • 8. CREDITS: This presentation template was created by Slidesgo, and includes icons by Flaticon, and infographics & images by Freepik and content by Swetha Tandri Thanks!