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Introduction to pharmaceutical
chemistry
Prepared & presented By
Priyanka Deshmukh
K.Y.D.S.C.T’s college of pharmacy, sakegaon
Define
Pharmaceutical
A compound manufactured for use as medical drug.
Pharmaceutical chemistry
Study of chemistry of organic and inorganic
pharmaceutical.
1. This course is designed to import basic knowledge on the chemical structure,
storage conditions and medicinal uses of organic and inorganic chemical
substance used as drugs and pharmaceuticals.
2. Also the course discuss the impurities, quality control aspects of chemical
substance used in pharmaceutical.
Scope
1. This course will discuss the following aspects of the chemical substance
used as drugs and pharmaceutical for various disease conditions.
2. Chemical classification, chemical name, chemical structure.
3. Pharmacological uses, doses, stability and storage conditions.
4. Different types of formulation dosage form available and their band names.
5. Impurity testing and basic quality control tests.
Accuracy
1. Accuracy is the difference between the true value and the
value of experimental result.
2. Accuracy means closeness of an experimental results with
true value or actual result.
1. Precision means reprocibility.
2. Precision is the variability among replicate
measurement. i,.e. How close the values the results of
replicate measurement are to each other.
Precision
Significant figures
1. Significant figure are the digits necessary to express results which are
constant with the precision of the measurement.
2. In other words significant figures are the digits that are placed in order
to give the value of a number.
3. E.g.in the quality represented by the number 346 the digits 3,4and 6 are
significant figures.
4. Zero is significant figures in some while in other cases where it is used to
locate the decimal point is zero is not considered as significant figures.
5. In number 30.6 the zero is significant but in the number 0.0235 the zero
before the point is not significant but shows the orders of magnitate of the
digits.
Error
Error = True error – Measured value
Determine error Indetermine error
Types of Error
Systematic error
Constant error
Random error
Systematic error
Determine error
 These error can be determinable.
 Can be either avoided or corrected.
 They may be constant or variable.
 They arise from causes such as
Personal error
1. Poorly judged visual end
point (colour changes) due to
colour blindness or due to
late reading of end points.
2. Mathematical error in
calculation.
By incorrect procedure
1. Incorrect sampling
2. Improper selection of
indicator.
3. Impurities in reagents.
4. Contamination of precipitate.
Instrumental error
1. Incorrect weights.
2. Inequal lengths of the arms
of the balance.
3. Poorly calibrated flasks,
burettes and pipettes.
Indetermine error
 Cannot be determine.
 The causes of such error are difficult to detect.
 These error are seen in slight variation in a series of observation made by the
same analyst under identical conditions.
 Multiple trials help to minimize.
No error Random error Systematic error
Accuracy
Accuracy
Precision
Precision

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Introduction to Pharmaceutical Chemistry

  • 1. Introduction to pharmaceutical chemistry Prepared & presented By Priyanka Deshmukh K.Y.D.S.C.T’s college of pharmacy, sakegaon
  • 2. Define Pharmaceutical A compound manufactured for use as medical drug. Pharmaceutical chemistry Study of chemistry of organic and inorganic pharmaceutical.
  • 3. 1. This course is designed to import basic knowledge on the chemical structure, storage conditions and medicinal uses of organic and inorganic chemical substance used as drugs and pharmaceuticals. 2. Also the course discuss the impurities, quality control aspects of chemical substance used in pharmaceutical. Scope
  • 4. 1. This course will discuss the following aspects of the chemical substance used as drugs and pharmaceutical for various disease conditions. 2. Chemical classification, chemical name, chemical structure. 3. Pharmacological uses, doses, stability and storage conditions. 4. Different types of formulation dosage form available and their band names. 5. Impurity testing and basic quality control tests.
  • 5. Accuracy 1. Accuracy is the difference between the true value and the value of experimental result. 2. Accuracy means closeness of an experimental results with true value or actual result. 1. Precision means reprocibility. 2. Precision is the variability among replicate measurement. i,.e. How close the values the results of replicate measurement are to each other. Precision
  • 6. Significant figures 1. Significant figure are the digits necessary to express results which are constant with the precision of the measurement. 2. In other words significant figures are the digits that are placed in order to give the value of a number. 3. E.g.in the quality represented by the number 346 the digits 3,4and 6 are significant figures. 4. Zero is significant figures in some while in other cases where it is used to locate the decimal point is zero is not considered as significant figures. 5. In number 30.6 the zero is significant but in the number 0.0235 the zero before the point is not significant but shows the orders of magnitate of the digits.
  • 7. Error Error = True error – Measured value Determine error Indetermine error Types of Error Systematic error Constant error Random error Systematic error
  • 8. Determine error  These error can be determinable.  Can be either avoided or corrected.  They may be constant or variable.  They arise from causes such as Personal error 1. Poorly judged visual end point (colour changes) due to colour blindness or due to late reading of end points. 2. Mathematical error in calculation. By incorrect procedure 1. Incorrect sampling 2. Improper selection of indicator. 3. Impurities in reagents. 4. Contamination of precipitate. Instrumental error 1. Incorrect weights. 2. Inequal lengths of the arms of the balance. 3. Poorly calibrated flasks, burettes and pipettes.
  • 9. Indetermine error  Cannot be determine.  The causes of such error are difficult to detect.  These error are seen in slight variation in a series of observation made by the same analyst under identical conditions.  Multiple trials help to minimize. No error Random error Systematic error Accuracy Accuracy Precision Precision