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Role of growth factors in a tissue engineered construct
Done by :
T. Mugesh (2007019)
M. Muthupavithran (2007020)
S. Nandana (2007021)
J. Nandhakumar (2007022)
 Growth factors are critical molecules for
tissue repair and regeneration. Therefore,
recombinant growth factors have raised a
lot of hope for regenerative medicine
applications
 While using growth factors to promote
tissue healing has widely shown promising
results in pre-clinical settings, their
success in the clinic is not a forgone
conclusion.
Growth Factors engineering strategies in regenerative medicine.
Strategies to control spatial and temporal presentations (A), stability (B),
and signaling (C).
https://www.frontiersin.org/articles/10.3389/fbioe.2019.00469/full
Introduction
Growth factor, any of a group of proteins that stimulate the
growth of specific tissues. Growth factors play an important role
in promoting cellular differentiation and cell division, and they
occur in a wide range of organisms, including insects,
amphibians, humans, and plants.
https://www.sciencedirect.com/science
/article/abs/pii/S0168365919302846
https://www.researchgate.net/figure/Summary-of-critical-growth-factor-in-tissue-repair-10-Growth-Factors-Roles-
in_tbl1_320872012
https://www.semanticscholar.org/paper/Growth-factors-in-wound-healing%3A-the-present-and-Dinh-
Braunagel/b0200b62357f692ca70afbcd454f47c83767d978
https://en.wikipedia.org/wiki/
Tissue_engineering
Skin cells (epidermal growth factor, EGF)
Nerve cells (nerve growth factor, NGF)
Connective tissue or mesenchymal cells
(fibroblast growth factor, FGF) thrombus-
forming cells that line blood vessels
(platelet- derived growth factor, PDGF)
https://www.openaccessgovernment.org/bioscien
ce-connecting-growth-factors/75289/
Growth Factors are natural proteins in
our body that promote the growth,
organization and maintenance of cells
and tissues, including the skin. They
act as chemical messengers,
communicating with skin cells to
stimulate growth. They're essential to
wound healing and skin repair.
Ang, angiopoietin
bFGF, basic fibroblast growth factor
BMP, bone morphogenetic protein
EGF, epidermal growth factor
FGF, fibroblast growth factor
HGF, hepatocyte growth factor
IGF, insulin-like growth factor
NGF, nerve growth factor
PDGF, platelet-derived growth factor
TFG, transforming growth factor
Common growth factors used in tissue engineering
 https://www.frontiersin.org/articles/10.3389/fbioe.2019.00469/full
 https://www.sciencedirect.com/science/article/abs/pii/S0168365919302846
 https://www.openaccessgovernment.org/bioscience-connecting-growth-
factors/75289/
 https://www.semanticscholar.org/paper/Growth-factors-in-wound-healing%3A-the-
present-and-Dinh-Braunagel/b0200b62357f692ca70afbcd454f47c83767d978
 https://www.researchgate.net/figure/Summary-of-critical-growth-factor-in-tissue-
repair-10-Growth-Factors-Roles-in_tbl1_320872012
REFERENCE
Role of growth factors in a tissue engineered.pptx

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Role of growth factors in a tissue engineered.pptx