Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disorder characterized by the development of autoantibodies and immune complexes in association with a wide variety of clinical manifestations and tissue damage. Evaluation of disease activity is useful as a guide in therapy. Drugs used for SLE therapy is given based on the symptoms and severity of illness. This research target to describe the characteristic of SLE patients, disease characteristics, evaluate the accuracy of patient, accuracy of indication, accuracy of dosing, potential interactions, and side effects that may occur in the use of the drug in patients with SLE. This study was a non-experimental and descriptive study using purposive sampling techniques and data collection concurrently. The sample used in this study were patients who were diagnosed SLE by doctor, got therapy of SLE and were willing to be interviewed. Results of research conducted on 19 patients who met the inclusion criteria, the obtained results that SLE affected more women in the age group 26-35 years was as much as 42.11%, SLE disease activity more suffered severe and very severe respectively 31.58%, characteristics most comorbidities were allergic by 20%, accuracy of patients 84.21%, accuracy of indication 89.47%, accuracy of dosing 52.63%, the potential interaction 68.42%, and 100% of patients experience side effects of drugs.

1. EVALUASI PENGGUNAAN OBAT DAN PENGUKURAN AKTIVITAS PENYAKIT
PADA PASIEN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)
Meika Widya Ningrum1
, M. Caecilia N. Setiawati H.2
, Sri Hari Wahyuni3
1,2
Sekolah Tinggi Ilmu Farmasi “Yayasan Pharmasi” Semarang
3
Instalasi Farmasi Rumah Sakit Panti Wilasa “Dr. Cipto” Semarang
SARI
Systemic Lupus Erythematosus adalah gangguan autoimun multisistem
kronis ditandai dengan berkembangnya autoantibodi dan kompleks imun dalam
berbagai manifestasi klinis dan kerusakan jaringan. Evaluasi aktivitas penyakit ini
berguna sebagai panduan dalam pemberian terapi. Obat yang digunakan untuk
terapi SLE diberikan berdasarkan gejala dan tingkat keparahan penyakitnya.
Tujuan dari penelitian ini adalah mengetahui gambaran karakteristik pasien SLE,
karakteristik penyakit, penggunaan obat pada pasien SLE berdasarkan parameter
tepat pasien, tepat indikasi, tepat dosis, mengetahui adanya potensi interaksi obat,
dan efek samping yang muncul selama penggunaan obat pada pasien SLE.
Penelitian ini merupakan penelitian non eksperimental dengan jenis penelitian
bersifat deskriptif, pengambilan data secara concurrent dan teknik sampling yang
digunakan adalah purposive sampling. Sampel yang digunakan dalam penelitian
ini adalah pasien yang didiagnosa menderita SLE oleh dokter, mendapatkan terapi
obat-obat SLE dan bersedia untuk diwawancara. Penelitian dilakukan terhadap 19
pasien diperoleh hasil yang menunjukkan bahwa SLE lebih banyak diderita oleh
perempuan pada kelompok usia 26-35 tahun yaitu sebanyak 42,11%, penyakit
SLE yang lebih banyak diderita memiliki aktivitas berat dan sangat berat yaitu
masing-masing 31,58%, penyakit penyerta yang paling banyak adalah alergi
sebesar 20%, ketepatan pasien sebesar 84,21%, ketepatan indikasi sebesar
89,47%, ketepatan dosis 52,63%, potensi interaksi 68,42%, dan 100% pasien
mengalami efek samping obat.
Kata kunci: Systemic Lupus Erythematosus, pasien, aktivitas penyakit, obat,
evaluasi penggunaan

2. DRUG USE EVALUATION AND MEASUREMENT OF DISEASE ACTIVITY
IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) PATIENTS
Meika Widya Ningrum1
, M. Caecilia N. Setiawati H.2
, Sri Hari Wahyuni3
1,2
Sekolah Tinggi Ilmu Farmasi “Yayasan Pharmasi” Semarang
3
Instalasi Farmasi Rumah Sakit Panti Wilasa “Dr. Cipto” Semarang
ABSTRACT
Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune
disorder characterized by the development of autoantibodies and immune
complexes in association with a wide variety of clinical manifestations and tissue
damage. Evaluation of disease activity is useful as a guide in therapy. Drugs used
for SLE therapy is given based on the symptoms and severity of illness. This
research target to describe the characteristic of SLE patients, disease
characteristics, evaluate the accuracy of patient, accuracy of indication, accuracy
of dosing, potential interactions, and side effects that may occur in the use of the
drug in patients with SLE. This study was a non-experimental and descriptive
study using purposive sampling techniques and data collection concurrently. The
sample used in this study were patients who were diagnosed SLE by doctor, got
therapy of SLE and were willing to be interviewed. Results of research conducted
on 19 patients who met the inclusion criteria, the obtained results that SLE
affected more women in the age group 26-35 years was as much as 42.11%, SLE
disease activity more suffered severe and very severe respectively 31.58%,
characteristics most comorbidities were allergic by 20%, accuracy of patients
84.21%, accuracy of indication 89.47%, accuracy of dosing 52.63%, the potential
interaction 68.42%, and 100% of patients experience side effects of drugs.
Keywords: Systemic Lupus Erythematosus, patients, disease activity, medications,
evaluation of drug use