Introduction to pharmaceutical chemistry, source types of errors & impurities in pharmaceuticals Imp MCQs Question With Ans. Prepared By: Mr. GULAM MUHEYUDDEEN ASSISTANT PROFESSOR DEPARTMENT OF PHARMACEUTICAL CHEMISTRY Jahangeerabad Institute of technology (Faculty Of Pharmacy) BARABANKI

1. TOPICS
Introduction to pharmaceutical chemistry,
source types of errors &
impurities in pharmaceuticals Imp MCQs
Question With Ans.
PREPARED BY ,
GULAM MUHEYUDDEEN
ASSISTANT PROFESSOR
DEPARTMENT OF PHARMACEUTICAL CHEMISTRY
Jahangeerabad Institute of technology (Faculty Of Pharmacy)
BARABANKI

2. 1. Lead acetate cotton plug is used in limit test for arsenic for
which of the following?
a) To permute release of phosphine gas.
a) To allow uniform passage of arsenious gas formed.
a) To avoid passage of hydrogen sulphide gas
a) To improve the efficiency of reaction

3. 1. Lead acetate cotton plug is used in limit test for arsenic for
which of the following?
a) To permute release of phosphine gas.
a) To allow uniform passage of arsenious gas formed.
a) To avoid passage of hydrogen sulphide gas
a) To improve the efficiency of reaction

5. 2. In the limit test for lead, lead present as a impurity is extracted
by using------
a) Barium sulphate
a) Dithizone solution.
a) Silver nitrate
a) Sodium phosphate

6. Principle: Limit test of lead is based on the reaction of lead and diphenylthiocabazone
(dithizone) in alkaline solution to form lead dithizone complex which is read in color.
Dithizone is green in color in chloroform and lead-dithizone complex is violet in color, so
the resulting color at the end of process is red

7. 1. In the limit test for lead, lead present as a impurity is extracted
by using------
a) Barium sulphate
a) Dithizone solution.
a) Silver nitrate
a) Sodium phosphate

8. 3. The limit test of sulphate has been based upon the precipitation of sulphate
with which of the following?
a) Barium chloride and silver chloride
a) Silver nitrate and hydrochloric acid.
a) Barium chloride and hydrochloric acid
a) Silver chloride and sulfuric acid

9. 3. The limit test of sulphate has been based upon the precipitation of
sulphate with which of the following?
a) Barium chloride and silver chloride
a) Silver nitrate and hydrochloric acid.
a) Barium chloride and hydrochloric acid
a) Silver chloride and sulfuric acid

10. Principle: Limit test of sulphate is based on the reaction of soluble sulphate with
barium chloride in presence of dilute hydrochloric acid to form barium sulphate
which appears as solid particles (turbidity) in the solution.

11. 4. The limit test of arsenic is based upon which of the following test?
a) Karl fisher test
a) Gutzeit test
a) Nitrate test
a) Gold bitters test

12. 4. The limit test of arsenic is based upon which of the following
test?
a) Karl fisher test
a) Gutzeit test
a) Nitrate test
a) Gold bitters test

13. 5. In limit test of iron purple colour is due to formation
of……………………?
a) Ferrous thioglycolate
a) Glycolate
a) Ferric thioglycolate
a) Glycolic acid

14. 5. In limit test of iron purple colour is due to formation
of……………………?
a) Ferrous thioglycolate
a) Glycolate
a) Ferric thioglycolate
a) Glycolic acid

15. Principle: Limit test of Iron is based on the reaction of iron in ammonical solution
with thioglycollic acid in presence of citric acid to form iron thioglycolate which is pale
pink to deep reddish purple in color. Earlier aamoniumthiocyanate reagent was used for the
limit test of iron

16. 6. Apparatus is used for limit test is:
a) Measuring cylinder
a) Conical flask
a) Nessler cylinder
a) Test tube

17. 6. Apparatus is used for limit test is:
a) Measuring cylinder
a) Conical flask
a) Nessler cylinder
a) Test tube

18. 7. Limit test are ------test designed to identify and control small
quantities of impurity.
a) Quantitative
b) Qualitative
c) Physiochemical
d) Therapeutic

19. 7. Limit test are ------test designed to identify and control small
quantities of impurity.
a) Quantitative
b) Qualitative
c) Physiochemical
d) Therapeutic

20. 8. Limit test for sulphate has been based upon the precipitate of sulphate with-----
----in the presence of ----------.
a) Barium chloride and hydrochloric acid
a) Magnesium sulphate and sulfuric acid
a) Silver nitrate and sulfuric acid
a) Magnesium sulphate and hydrochloric acid

21. 8. Limit test for sulphate has been based upon the precipitate of
sulphate with---------in the presence of ----------.
a) Barium chloride and hydrochloric acid
a) Magnesium sulphate and sulfuric acid
a) Silver nitrate and sulfuric acid
a) Magnesium sulphate and hydrochloric acid

22. 9. Which of the following error is unpredictable?
a) Determinant error
a) Indeterminate error
a) Cross error
a) None of the above

23. 9. Which of the following error is unpredictable?
a) Determinant error
a) Indeterminate error
a) Cross error
a) None of the above

24. 10. ………………. Are denotes the difference between the
measured and true value.
a) Impurity
b) Limit test
c) Error
d) None of the above

25. 10. ………………. Are denotes the difference between the
measured and true value.
a) Impurity
b) Limit test
c) Error
d) None of the above

26. 11. In ………………synthetic samples cannot be prepared from a
standard analytical agency.
a) Absolute method
b) Comparative method
c) Both of them
d) None of them

27. 11. In ………………synthetic samples cannot be prepared from a
standard analytical agency.
a) Absolute method
b) Comparative method
c) Both of them
d) None of them

28. 12. Pharmaceuticals …………………….are unwanted chemicals, that remains with
active pharmaceuticals ingredient's or drug products formulation.
a) Errors
b) Impurities
c) Limit test
d) None of the above

29. 12. Pharmaceuticals …………………….are unwanted chemicals, that remains with
active pharmaceuticals ingredient's or drug products formulation.
a) Errors
b) Impurities
c) Limit test
d) None of the above

30. 13. …………………..errors caused due to either in correct adoption
of an assay method or an incorrect graduation read out by an
analyst.
a) Determinate
b) Indeterminate
c) Accuracy
d) Precision

31. 13. …………………..errors caused due to either in correct adoption
of an assay method or an incorrect graduation read out by an
analyst.
a) Determinate
b) Indeterminate
c) Accuracy
d) Precision

32. 14. ………………….are quantitative or Sami-quantitative tests intended for
identifying and controlling small quantities of impurities which may occur in a
substance.
a) Impurities
b) Errors
c) Accuracy
d) Limit test

33. 14. ………………….are quantitative or Sami-quantitative tests
intended for identifying and controlling small quantities of
impurities which may occur in a substance.
a) Impurities
b) Errors
c) Accuracy
d) Limit test

34. 15. …………………….. Are observed to be rather independent of the magnitude of
the measured amount.
a) Reagent errors
b) Constant errors
c) Additive errors
d) Proportional error

35. 15. …………………….. Are observed to be rather independent of the magnitude of
the measured amount.
a) Reagent errors
b) Constant errors
c) Additive errors
d) Proportional error