Measures of Central Tendency: Mean, Median and Mode
Yebchaye Degefa
1. The state and application of Biotechnology for the
production of Veterinary vaccines and diagnostic
tools
Yebchaye Degefa
African Union Pan-African veterinary vaccine center
AU-PANVAC
AU-PANVAC
3. INTRODUCTION
• Livestock production contributes substantially
towards income and is a good source of quality food.
• Means of earning foreign currency
• Demand for animal products is increasing. The UN
predicts for the region a population between 1.5 and
2 billion by 2050.
• The demand for animal food products in low-income
areas of the world is rising rapidly
AU-PANVAC
4. INTRODUCTION
• But Livestock diseases(LD) still remains one of the
major threat to animal production in Africa
• Despite the development of new technologies and
strategies, these disease refuse to be controlled
• Surprisingly most of these diseases are vaccine
preventable diseases
• However, we have one success story, Rinderpest was
eradicated and Africa is proud to be part of that effort
AU-PANVAC
5. INTRODUCTION
• It was in an effort to learn from the Rinderpest
experience that AU-PANVAC was established in
Africa in 1986
• AU-PANVAC is the African Union Organization
mandated to provide International Independent
quality control of all veterinary vaccines produced or
imported into Africa
• It is located about 50 kilometres outside Addis Ababa
AU-PANVAC
6. Rinderpest almost
controlled due to Good
quality vacc. production
major resurgence of
disease led to decline in
quality of vaccine
Audit by FAO to
determine reasons for
failure of campaign
2 QC Centers established
to ensure quality of
vaccines used in Africa
2 Centers merged-to
form one Organization
PANVAC
1993
PANVAC became an AU
Technical Centre called AU-
PANVAC
198619831980s1960s 2004
Establishment of AU-PANVAC
AU-PANVAC
7. Establishment of AU-PANVAC
AU-PANVAC
In recognition of the role played by AU-PANVAC
The Mandates were expanded to include
• Quality Control of all vaccines against priority animal
diseases
• Production of essential biological reagents
8. Transfer of vaccine
production
technologies in
Africa; .
International
Independent
Quality Control of
Veterinary
Vaccines produced
in Africa.
Provide training and
technical support
services to
veterinary
laboratories.
Produce and
distribute essential
biological reagents
for animal disease
diagnosis and
surveillance.
standardization of
vaccines
production and
harmonization of
their quality
control techniques
in Africa
AU-PANVAC Mandates: FAO Reference Centre
FAO-OIE Rinderpest Holding
Facility
AU-PANVAC present status:
OIE Collaborating Centre
1
5
4
3
2
ISO 9001:2015 Certified
Establishment of AU-PANVAC
AU-PANVAC
10. Harmonization of Veterinary vaccine registration on the
continent
Maintaining Africa free from Rinderpest
2. Specific Mandates of AU-PANVAC
3. Collaboration with partners
Projects on vaccine development/improvement and anima
disease control efforts
1. General Mandates of AU-PANVAC
Expanded to include vaccines against priority animal
diseases
AU-PANVAC
Establishment of AU-PANVAC
11. APPLICATION OF BIOTECHNOLOGY INTHE
PRODUCTION OF VETERINARY VACCINES AND
DIAGNOSTICS
Projects on vaccine development/improvement
several promising new generation of vaccines being
considered, these include:
•Thermo tolerance vaccine
•multivalent vaccines,
•Recombinant vaccines,
• DNA vaccines and synthetic peptide.
•Vectored vaccines
AU-PANVAC
12. APPLICATION OF BIOTECHNOLOGY
AU-PANVAC
AU-PANVAC is also implementing Biotechnology Techniques
for reagents production and analysis
Recombinant Protein Expression using:
Baculovirus Expression Vector System (BEVS)
E.Coli
o Baculo Viruses are insect-specific viruses
o They are very powerful & most popular methods for the
production of large quantities of recombinant proteins
within eukaryotic cells
13. APPLICATION OF BIOTECHNOLOGY …
AU-PANVAC
AU-PANVAC is also implementing Biotechnology Techniques
for reagents production and analysis
Recombinant Protein Expression using:
Baculovirus Expression Vector System (BEVS)
E.Coli
14. APPLICATION OF BIOTECHNOLOGY
AU-PANVAC
AU-PANVAC is also implementing Biotechnology Techniques
for reagents production and analysis
Protein/Antigen analysis
SDS-PAGE
Western Blot
15. CONCLUSION
Although conventional vaccines and diagnostic assays
are still being used routinely and are to some degree
effective,
• Biotechnology presents great opportunities for
enhancing our capacities and efficiency in vaccine
production and diagnostic techniques
• Presently, new molecular techniques have broadened
the scope of veterinary vaccine production and
provided powerful new tools for diagnostics
AU-PANVAC
16. CONCLUSION
• Biotechnology has enabled production of highly
effective vaccines; and rapid/ specific diagnosis of
animal diseases
• AU-PANVAC is available to collaborate with
Partners in the development and adoption of new
biotechnologies for the benefit of livestock
development and the African people
• Biotechnology in animal agriculture is the key that
will enable Africa and the world to sustainably feed
its growing population
AU-PANVAC
Diseases such as Pest des Petits Ruminants (PPR), Contagious Bovine Pleuropneumonia (CBPP), Foot and Mouth Disease and Avian Influenza still deny Africa the opportunity to reach self sufficiency in livestock production
Rinderpest, a disease which devastated most of the world was eradicated and Africa is proud to be part of that global effort. Africa is presently using the lesson learned from the rinderpest eradication for other transboundary animal diseases