Nanotechnology can show the promising therapeutic potential in Alzheimer's Disease.

1. AN EMERGING
POTENTIAL OF
NANOTECHNOLOGY IN
TREATMENT OF
ALZHEIMER’S DISEASE
DEVASHISH MEHTA*, AMAR
GOYAL, KULDEEP K. SHARMA.

2. INTRODUCTION
 Alzheimer's disease is a neurodegenerative
brain disorder.
 It is the most common form of dementia.
 It usually starts in late middle age or in old
age(above 65 years).
 It is characterized by progressive memory loss.
 The main pathophysiological hallmark of AD are
deposition of Amyloid beta (Aβ) peptides,
Neurofibrillary tangles formation, decrease level
of acetylcholine and increased oxidative stress.

3. NANOTECHNOLOGY
 Nanotechnology is a manipulation of matter
on an atomic, molecular and supermolecular
scale.
 The manipulation of matter with at least one
dimensional size from 1 to 100
nanometers(nm)
 Nanotechnology may be able to create new
material or devices with a wide range of
application like: Nanomedicine.

4. NANOTECHNOLOG
Y IN A.D.
DIAGNOS
IS &
IMAGING
TREATMENT &
PREVENTION
REGENRATION
THERAPY

5. DIAGNOSIS AND IMAGING
Nanoparticle based methods for early and
sensitive detection of AD biomarkers in
CSF/blood; nanomaterials for in-vivo imaging
of beta-amyloid plaques.
Example: Quantum Dot.

6. THERAPEUTIC AND PREVENTION
 Nano-enabled delivery of therapeutic:
They cross the BBB and nanomaterials inhibits
Amyloid beta peptide aggregation or break
oligomers and fibrils.
Example: Rivastigimine + PnBA (poly n
butylcyanoacrylate) which is coated with
polysorbitol 80.

7. THERAPEUTIC AND PREVENTION
 Delivery of neurotransmitter Ach with
nanotechnology:
Recently an approach to deliver the Ach to
brain with nanoparticles ‘Single wall carbon
nanotubes (SWCNTs)’ as a carrier.
Ach transfer via olfactory nerve axons rather
than BBB

8. M.O.A

9. THERAPEUCTIC AND PREVENTION
 Nano-enabled Neuroprotective Approaches
Of Antioxidant:
As increase in the presence of free radicals
due to oxidative stress can play an important
role in neural degenration. Amyloid beta
induced oxidative stress has been implicated
in AD.
Example: Buckminsterfullerence (C60).

10. M.O.A OF NANOPAERTICLES (ANTIOXIDANT)

11. REGENRATION THERAPY
AD is a neurodegenrative disorder. We can
stop or slow the degenration of neurons.A
latest approach in AD we can regenrate the
neurons with help of Stem Cell and the
nanotechnology.
 The development of nano-engineered
scaffolds that can mimic the extracellular
matrix to support and promote the growth
and controlled differentiation of neural
progenitor cells in-vivo for repairing damage.

12. CONCLUSION
With the help of novel studies, we can
conclude that nanotechnology can show the
promising therapeutic potential in AD.

13. REFERENCES
www.nanowerk.com
www.webmd.com
 M. Citron, Alzheimer’s disease: treatments in
discovery and development. Nat. Neurosci.,
5 (Suppl) Nov 2002, 1055–1057.