An emerging potential of nanotechnology in treatment of alzheimer’s disease
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Nanotechnology shows potential for treating Alzheimer's disease in several ways: 1) Nanoparticles can help diagnose and image Alzheimer's by detecting biomarkers in blood/CSF and imaging amyloid plaques. 2) Nanoparticles can help deliver therapeutics across the blood-brain barrier to inhibit amyloid beta aggregation and break up oligomers/fibrils. 3) Nanoparticles may deliver acetylcholine to the brain via olfactory nerve axons to treat neurotransmitter deficiencies. 4) Nanoparticles can help deliver antioxidant therapeutics to reduce oxidative stress implicated in neural degeneration. 5) Nanotechnology is being explored to regenerate neurons using nano-engineered scaffolds that mimic the extracellular matrix
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An emerging potential of nanotechnology in treatment of alzheimer’s disease
- 1. AN EMERGING POTENTIAL OF NANOTECHNOLOGY IN TREATMENT OF ALZHEIMER’S DISEASE DEVASHISH MEHTA*, AMAR GOYAL, KULDEEP K. SHARMA.
- 2. INTRODUCTION Alzheimer's disease is a neurodegenerative brain disorder. It is the most common form of dementia. It usually starts in late middle age or in old age(above 65 years). It is characterized by progressive memory loss. The main pathophysiological hallmark of AD are deposition of Amyloid beta (Aβ) peptides, Neurofibrillary tangles formation, decrease level of acetylcholine and increased oxidative stress.
- 3. NANOTECHNOLOGY Nanotechnology is a manipulation of matter on an atomic, molecular and supermolecular scale. The manipulation of matter with at least one dimensional size from 1 to 100 nanometers(nm) Nanotechnology may be able to create new material or devices with a wide range of application like: Nanomedicine.
- 4. NANOTECHNOLOG Y IN A.D. DIAGNOS IS & IMAGING TREATMENT & PREVENTION REGENRATION THERAPY
- 5. DIAGNOSIS AND IMAGING Nanoparticle based methods for early and sensitive detection of AD biomarkers in CSF/blood; nanomaterials for in-vivo imaging of beta-amyloid plaques. Example: Quantum Dot.
- 6. THERAPEUTIC AND PREVENTION Nano-enabled delivery of therapeutic: They cross the BBB and nanomaterials inhibits Amyloid beta peptide aggregation or break oligomers and fibrils. Example: Rivastigimine + PnBA (poly n butylcyanoacrylate) which is coated with polysorbitol 80.
- 7. THERAPEUTIC AND PREVENTION Delivery of neurotransmitter Ach with nanotechnology: Recently an approach to deliver the Ach to brain with nanoparticles ‘Single wall carbon nanotubes (SWCNTs)’ as a carrier. Ach transfer via olfactory nerve axons rather than BBB
- 8. M.O.A
- 9. THERAPEUCTIC AND PREVENTION Nano-enabled Neuroprotective Approaches Of Antioxidant: As increase in the presence of free radicals due to oxidative stress can play an important role in neural degenration. Amyloid beta induced oxidative stress has been implicated in AD. Example: Buckminsterfullerence (C60).
- 10. M.O.A OF NANOPAERTICLES (ANTIOXIDANT)
- 11. REGENRATION THERAPY AD is a neurodegenrative disorder. We can stop or slow the degenration of neurons.A latest approach in AD we can regenrate the neurons with help of Stem Cell and the nanotechnology. The development of nano-engineered scaffolds that can mimic the extracellular matrix to support and promote the growth and controlled differentiation of neural progenitor cells in-vivo for repairing damage.
- 12. CONCLUSION With the help of novel studies, we can conclude that nanotechnology can show the promising therapeutic potential in AD.
- 13. REFERENCES www.nanowerk.com www.webmd.com M. Citron, Alzheimer’s disease: treatments in discovery and development. Nat. Neurosci., 5 (Suppl) Nov 2002, 1055–1057.