Details of Antiseptics & Antifungal drugs available in Bangladesh

2. Submitted By :
Reg No. 14-05989
14-06043
14-06155

3. Antiseptics

5. Some common antiseptics & their actions :
, including ethanol and 2-propanol/isopropanol
are sometimes referred to as . They are used
to disinfect the skin before injections are given, among
other uses.
is used as a skin antiseptic and
to treat inflammation of the gums (gingivitis).
is used as a 6% (20 Vols) solution to
clean and deodorize wounds and ulcers. More commonly,
3% solutions of hydrogen peroxide have been used in
household first aid for scrapes, etc.

6. is usually used in an alcohol solution
(called ) or as Lugol's iodine
solution as a pre- and post-operative antiseptic.
The great advantage of iodine antiseptics is their
wide scope of antimicrobial activity, killing all
principal pathogens and, given enough time,
even spores, which are considered to be the
most difficult form of microorganisms to be
inactivated by disinfectants and antiseptics.
, currently
increasingly used in continental Europe, often as
a chlorhexidine substitute.

7. is an
antimicrobial compound suitable for clinical use in critically
colonized or infected acute and chronic wounds. The
physicochemical action on the bacterial envelope prevents
or impedes the development of resistant bacterial strains.
is a mild antiseptic.
is a sodium hypochlorite solution,
originally also containing boric acid to lower pH. It is mostly
used on live tissues for cleaning wounds off bacteria, fungi
and viruses. Because of practicality of preparation and
lower cost, it is largely used on Veterinary Medicine
treatments. It's colourless and doesn't stain the animal's fur,
so it doesn't affect its aesthetics or commercial value.

8. Some common antiseptics available in
Bangladesh :
Brand Name Contains
Dosage
Form
Manufacturer Price(Tk.)
CLENOL
Chlorhexidine hydrochloride 0.1% & cetrimide
0.5%
Cream
Mystic Pharmaceuticals
Ltd.
30gm tube: 19.00 MRP
GERMISOL
Chlorhexidine gluconate 0.5% w/w in 70%
Isopropanol solutions
Hand Rub
Square
Pharmaceuticals Ltd.
50ml bot: 23.40 MRP; 250ml
bot: 79.25 MRP
HANDIRUB
Chlorhexidine gluconate 0.5% w/v in Isopropyl
alcohol 20% w/v solution
Hand Rub
Eskayef Bangladesh
Ltd.
50ml bot: 30.00 MRP; 200ml
bot: 80.00 MRP
HEXISCRUB Chlorhexidine gluconate 4% solution Solution ACI Limited 250ml bot: 100.00 IP
HEXISOL
Chlorhexidine gluconate 0.5% w/w in 70%
Isopropanol solutions
Hand Rub ACI Limited
50ml bot: 31.00 IP; 250ml
bot: 105.00 IP
ORALON Chlorhexidine gluconate 0.2% w/v solution
Solution (Mouth
Wash)
ACI Limited 100ml bot: 35.00 IP
ORALON Dental Chlorhexidine gluconate 1% w/v gel Gel (Oral) ACI Limited 30gm tube: 40.00 IP
SAFETISOL
Chlorhexidine gluconate 0.5% w/w in 70%
Isopropyl alcohol solution
Solution
Silva Pharmaceuticals
Limited
50ml bot: 30.00 MRP; 200ml
bot: 80.00 MRP

9. Brand Name Contains
Dosage
Form
Manufacturer Price(Tk.)
SAVLON
Chlorhexidine hydrochloride 0.1% & cetrimide
0.5%
Cream ACI Limited
15gm tube: 12.00 IP; 30gm
tube: 22.00 IP
SAVLON (High
Concentration)
Chlorhexidine gluconate solution BP 1.5% w/w
& cetrimide BP 15% w/w
Solution ACI Limited 5 liter pack: 1415.00 MRP
SAVLON Liquid
Chlorhexidine gluconate 0.3% w/v + cetrimide
3% w/v solution
Solution ACI Limited
56ml bot: 15.00 IP; 112ml
bot: 23.00 IP; 1 liter: 110.00
IP
SEPNIL
Ch10rhexidine gluconate solution BP 1.5% w/v
& cetrimide BP 3% w/v
Solution
Square
Pharmaceuticals Ltd.
50ml bot: 11.00 MRP; 100ml
bot: 16.63 MRP
DETTOL Chloroxylenol 1.3% solution Lotion Reckitt Benckiser
56ml bot: 18.00 MRP; 100ml
bot:???? ; 750ml bot:????
POVIN Povidone-iodine 1% w/v solution
Gargle &
Mouthwash
Opsonin Pharma
Limited
100ml bot: 25.00 MRP
POVISEP Povidone-iodine 7.5% w/v aqueous solution Surgical Scrub
Jayson
Pharmaceuticals Ltd.
250ml bot: 177.00 MRP
POVISEP Povidone-iodine 1% w/v solution
Gargle &
Mouthwash
Jayson
Pharmaceuticals Ltd.
100ml bot: 25.00 MRP
VIODIN Povidone-iodine 1% w/v solution
Gargle &
Mouthwash
Square
Pharmaceuticals Ltd.
100ml bot: 25.00 MRP

12. An antifungal medication, also known as an
antimycotic medication, is a pharmaceutical
fungicide or fungistatic used to treat and
prevent mycosis such as
serious
systemic infections such as cryptococcal
meningitis, and others.

13. How antifungal medicines work :
Antifungal medicines work by either:
• Killing the fungal cells – for example, by affecting a
substance in the cell walls, causing the contents of
the fungal cells to leak out and the cells to die.
Or,
• Preventing the fungal cells growing and
reproducing.

15. Classes
 Polyene antifungals
A polyene is a molecule with multiple conjugated double bonds. A polyene antifungal
is a macrocyclic polyene with a heavily hydroxylated region on the ring opposite the
conjugated system. This makes polyene antifungals amphiphilic.
• Amphotericin B
• Candicidin
• Filipin – 35 carbons, binds to cholesterol (toxic)
• Hamycin
• Natamycin – 33 carbons, binds well to ergosterol
• Nystatin
• Rimocidin

16.  Imidazole, triazole, and thiazole antifungals
Azole antifungal drugs (except for abafungin)
inhibit the enzyme lanosterol 14 α-
demethylase; the enzyme necessary to
convert lanosterol to ergosterol. Depletion of
ergosterol in fungal membrane disrupts the
structure and many functions of fungal
membrane leading to inhibition of fungal
growth.

17.  Imidazoles
 Bifonazole  Butoconazole  Clotrimazole
 Econazole  Fenticonazole  Isoconazole
 Ketoconazole  Luliconazole  Miconazole
 Omoconazole  Sertaconazole  Tioconazole
 Sulconazole  Oxiconazole

18.  Triazoles
 Albaconazol
e
 Efinaconazole  Epoxiconazole
 Fluconazole  Isavuconazole  Itraconazole
 Posaconazole  Propiconazole  Ravuconazole
 Terconazole
Thiazoles
Abafungin
 Voriconazole

19.  Allylamines
Allylamines inhibit squalene epoxidase, another enzyme required
for ergosterol synthesis. Examples include amorolfin, butenafine,
naftifine, and terbinafine.
 Echinocandins
Echinocandins may be used for systemic fungal infections in
immunocompromised patients, they inhibit the synthesis of glucan in
the cell wall via the enzyme 1,3-Beta-glucan synthase:
• Anidulafungin
• Caspofungin
• Micafungin

20.  Others :
- have been shown to possess antifungal
properties.
– has antifungal properties, but must
be combined with a keratolytic agent such as in
Whitfield's ointment.
– (ciclopirox olamine) – is a
hydroxypyridone antifungal that interferes with
active membrane transport, cell membrane integrity,
and fungal respiratory processes. It is most useful
against tinea versicolour.

21. – an antimetabolite
pyrimidine analog.
– binds to polymerized microtubules
and inhibits fungal mitosis.
– discontinued due to the emergence of
more modern antifungals with fewer side effects.
– a thiocarbamate antifungal, which
inhibits fungal squalene epoxidase (similar
mechanism to allylamines like terbinafine).

22. – an unsaturated fatty acid derived
from natural castor oil; fungistatic, antibacterial,
antiviral, and inhibits Candida morphogenesis.
– a triarylmethane dye, it has antibacterial,
antifungal, and anthelmintic properties and was
formerly important as a topical antiseptic.
has antifungal properties.
- pyrimidine synthesis inhibitor.
disrupts fungal cell membrane dynamics by
interacting with ergosterol.

23.  Some common antifungals in Bangladesh [Trade names]
A. Topical Anti-fungal preparations :
Brand Name Contains Dosage Form Manufacturer Price(Tk.)
AFUN Clotrimazole 1% Cream Square Pharmaceuticals Ltd. 10gm tube: 25.00 MRP
CLOTRIM Clotrimazole 1% Cream ACME Laboratories Ltd.
5gm tube: 18.25 MRP; 10gm
tube: 28.50 MRP
DERMASIM Clotrimazole 1% Solution ACI Limited 20ml pack: 50.00 MRP
FUNGIN Clotrimazole 1% Cream
IBN SINA Pharmaceutical
Industry Ltd.
10gm cream: 30.00 MRP
ECONATE Econazole nitrate 1% Cream Incepta Pharmaceuticals Ltd. 10gm tube: 28.00 MRP
FUNGIDAL
Miconazole nitrate 2%
(20mg/gm)
Cream Square Pharmaceuticals Ltd. 10gm tube: 35.00 MRP
ECOZOL Econazole nitrate 1% Cream Opsonin Pharma Limited
10gm tube: 32.00 MRP;
30gm tube: 70.00 MRP
MICONEX
Miconazole nitrate 2%
(20mg/gm)
Cream ACI Limited 10gm tube: 35.00 MRP

24. B. Drugs for cutaneous mycoses :
Brand Name Contains Dosage Form Manufacturer Price(Tk.)
FULCINEX Griseofulvin 125mg/5ml suspension Suspension ACI Limited 60ml bot: 23.33 MRP
GRISO 500 Griseofulvin 500mg/tablet Tablet
Ziska Pharmaceuticals
Ltd.
100s pack: 350.00 MRP
MICORAL
Miconazole base 125mg USP in each
5ml, 2% w/w gel preparation
Gel (Oral) ACI Limited 15mg tube: 50.00 MRP
CANDEX Nystatin 100,000 units/1ml drop Drop
Square Pharmaceuticals
Ltd.
12ml bot: 22.65 MRP
CANSTAT Nystatin 500,000 units/tablet Tablet
Jayson Pharmaceuticals
Ltd.
100s pack: 278.00 MRP
FUNGISTIN Nystatin 100,000 units/1ml drop Drop
Beximco Pharmaceuticals
Ltd.
12ml bot: 22.74 MRP
MYCOCIN Nystatin 500,000 units/tablet Tablet
IBN SINA Pharmaceutical
Industry Ltd.
28s pack: 140.00 MRP
NYSTAT Nystatin 500,000 units/tablet Tablet
ACME Laboratories
Ltd.
50s pack: 253.00
MRP

25. C. Drugs for subcutaneous and systemic mycoses :
Brand Name Contains Dosage Form Manufacturer Price(Tk.)
FLUCON Fluconazole 50mg & 150mg/capsule Capsule Opsonin Pharma
Limited
50mg x 30s pack: 240.00 MRP;
150mg x 10s pack: 220.00 MRP
FLUCONAL Fluconazole 50mg & 150mg/tablet Tablet ACME Laboratories
Ltd.
50mg x 20s pack: 160.00
MRP; 150mg x 10s pack:
264.00 MRP
FLUCOSTAN Fluconazole INN 50mg/capsule Capsule Ziska
Pharmaceuticals Ltd.
50mg x 20s pack: 100.00
MRP
FLUGAL Fluconazole 50mg, 150mg &
200mg/capsule
Capsule Square
Pharmaceuticals Ltd.
50mg x 30s pack: 240.00 MRP;
150mg x 10s pack: 220.00 MRP;
200mg x 10s pack: 250.00 MRP
FLUNAC Fluconazole 50mg/5ml suspension Suspension Drug International
Ltd.
35ml bot: 70.00 MRP
I-ZOL Itraconazole INN 100mg/capsule Capsule
Popular
Pharmaceuticals Ltd.
12s pack: 180.00 MRP
KETOCON Ketoconazole 200mg/tablet Tablet
Opsonin Pharma
Limited
30s pack: 240.00 MRP
KETORAL Ketoconazole 200mg/tablet Tablet
Square
Pharmaceuticals Ltd.
30s pack: 270.00 MRP

26. D. Other Antifungal preparations:
Brand Name Contains Dosage
Form
Manufacturer Price(Tk.)
DERMIN Benzoic acid 6% & salicylic acid
3%
Ointment Jayson Pharmaceuticals
Ltd.
25gm pack: 13.30 MRP
ENSAL Benzoic acid 6% & salicylic acid
3%
Ointment Renata Ltd. 1kg pack: 265.00 MRP
WHITFIELD Benzoic acid 6% & salicylic acid
3%
Ointment Seema Pharmaceuticals
Ltd.
25gm pot: 8.60 MRP
TENAFIN Butenafine hydrochloride 1% Cream
Beximco Pharmaceuticals
Ltd.
15gm tube: 50.00 MRP
FINATER Terbinafine hydrochloride 1% Cream
Popular Pharmaceuticals
Ltd.
5gm tube: 50.00 IP
SKINABIN Terbinafine hydrochloride 1% Cream ACI Limited 15gm tube: 50.00 MRP
TERBEX Terbinafine hydrochloride 1% Cream
Beximco Pharmaceuticals
Ltd.
5gm tube: 35.00 IP
TERBIFIN Terbinafine hydrochloride 1% Cream Aristopharma Ltd. 5gm tube: 52.00 MRP
XFIN Terbinafine hydrochloride 1% Cream
Square Pharmaceuticals
Ltd.
5gm tube: 50.00 MRP

27. Common antifungals used in animals in Bangladesh :
• Oint. Dermin (Benzoic acid 6%+Salicylic acid 3%)
• Oint. Whitefield (Benzoic acid 6%+Salicylic acid 3%)
• Oint. Fungalin (Benzoic acid 6%+Salicylic acid 3%)

28.  Combined application of antiseptics &
antifungals