Antifungal drugs (Pharmacology)

1. Antifungal Drugs

2. Fungal

3. Classification
1. Antifungal antibiotics e.g- Amphotericin B, nystatin, hamycin, natamycin, griseofulvin.
2. Antimetabolites e.g- Flucytosine (5-FC).
3. Azoles e.g- Imidazoles, Clotrimazole, econazole, miconazole,
ketoconazole, butoconazole, oxiconazole, sulconazole,
isoconazole,Triazoles, Fluconazole, itraconazole, terconazole,
4. Miscellaneous e.g- Terbinafine, pneumocandins.
5. Other topical agents e.g- Tolnaftate, undecylenic acid, benzoic acid, salicylic acid,
selenium sulfide, ciclopirox olamine.

4. Site of action

5. 1. ANTIFUNGAL ANTIBIOTICS

6. Antifungal spectrum
Tarique Faheem

7. Mechanism of Action
• Amphotericin B binds to
ergosterol present in fungal cell
membrane and forms pores in
the cell membrane. Through
these pores, cell contents leak
out resulting in cell death. It is
given intravenously.
Tarique Faheem

8. Adverse effects
Tarique Faheem

9. Uses
Tarique Faheem

10. ii) Nystatin

11. Candidal Infections:
Oral thrush
Vaginal Candidiasis

12. iii) Hamycin
Hamycin is similar to nystatin. It is used topically for
cutaneous candidiasis and otomycosis.
Cutaneous candidiasis

13. iv) Griseofulvin

14. Mechanism of Action and Adverse effects

15. Uses

16. Superficial dermatophytosis

17. 2.Antimetabolites

18. 3. Azoles

19. Antifungal spectrum

20. Mechanism of Action

21. Ketoconazole (KTZ)

22. Preparation and Uses of Ketoconazole

23.  Clotrimazole and miconazole

24. Preparations

25.  Fluconazole

26. tinea infection & mucocutaneous infection

27.  Itraconazole

28.  Econazole, terconazole, tioconazole,
butoconazole, oxiconazole and
sulconazole

29.  Terbinafine

30. Drug used in superficial mycosis
Topical Oral
Ringworm An azole Terbinafine
Itraconazole
Candidiasis
Cutaneous Amphotericin
An azole
Cyclopirox
Nystatin
Oropharyngeal Amphotericin
An azole
Nystatin
Fluconazole
Itraconazole
Vaginal An azole
Nystatin
Fluconazole

31. Drugs used in fungal infections
Systemic fungal infection Drug of choice Alternative drugs
Invasive aspergillosis Sporotrichosis Itraconazole
Blastomycosis Amphotericin Itraconazole
Ketoconazole
Candidiasis Fluconazole Amphotericin , Flucytosine
Coccidioidomycosis Amphotericin
Itraconazole
Fluconazole
Ketoconazole
Cryptococcosis Amphotericin
+ Flucytosine
Fluconazole
Itraconazole
Histoplasmosis Amphotericin
Itraconazole
Fluconazole
Mucormycosis Amphotericin
Flucytosine
Itraconazole
Paracoccidioido- mycosis Fluconazole
Itraconazole
Amphetericin
Sporotrichosis Amphotericin Itraconazole