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Can’t Sleep?
The ABCs of Your ZZZs
Jenny H. Kim, MD, FCCP
75 E. Northfield Road
Livingston NJ 07039
The Essentials of Sleep
• Basics of “Good Sleep” – Sleep Overview
• Sleep Requirements – Sleep Deprivation
• Sleep Hygiene
• Sleep Disorders
 Obstructive Sleep Apnea
 Restless Legs
 REM Behavior Disorder
 Insomnia
 Narcolepsy
Importance of Healthy Sleep
• AASM and SRS Consensus Statement1
 “Adults should sleep 7 or more hours per night on a
regular basis to promote optimal health”
• American Thoracic Society Statement2
 “Sleep is an essential biological function with major roles
in recovery, energy conservation, and survival”
 “It is clear that good-quality sleep is critical for good
health and overall quality of life”
The Holy Grail
• A Good Night’s Sleep
How Much Sleep is Enough?
CDC Declares Sleep Disorders a
Public Health Epidemic
• In 2014 the Centers for Disease Control described
sleep deprivation as so pervasive in the United States
that it is considered a public health epidemic.
• Research conducted by the CDC indicates that large
numbers of Americans experience problems associated
with lack of sufficient sleep. For example:
 Almost 50 million people reported problems
concentrating during the day
 24 million people indicated lack of sleep interfered with
driving
 18 million people reported that sleep deficiency
interfered with job performance.
Third Pillar of Health
• Sleep is the third of the of 4 pillars of health which include
nutrition, physical fitness, sleep and stress control.
• The estimated cost of lost productivity is 63.2 billion dollars a
year!
• A primary factor for lost productivity is presenteeism, employees
showing up for work but operating at subpar levels due to sleep
loss.
Sleep Vs. Technology
• The biggest sleep distraction?
 1 in 2 people check right away if
they wake up in the middle of the
night
 1 in 4 people don’t silence their
phones while sleeping
 1 in 10 people are awoken by
their phones at least once a week
Screen Brightness – Blue Light
Leptin and Ghrelin
• Leptin - the appetite
suppressor, is the
hormone that tells
your brain when you're full.
• Ghrelin - the appetite
increaser, is the hormone
released primarily in the
stomach to signal hunger to
the brain.
• Just two nights of restricted
sleep were found to
significantly impact
hormones related to
appetite and drive to eat, as
well as self-reported
hunger.
Sleep Deprivation
Getting adequate sleep is not a luxury.
It is essential for good health.
Sleeping less than 7 hours is associated with:
While it still can’t cure the common cold…
Getting enough sleep can help prevent
catching a cold
Drowsy Driving
• National Highway Traffic Safety
Administration estimates that at
least 100,000 police reported
crashes are the direct effect of
driver fatigue
• Driving after 18 hours without
sleep = 2 alcoholic beverages
• Driving after 24 hours without
sleep = 4 alcoholic beverages
Sleep Hygiene
• Sleep hygiene - Habits and practices that are conducive to
sleeping well on a regular basis.
 Ensure an inviting sleep environment
 Ensure exposure to light during the day
 Limit daytime naps to 20-30 minutes
 Exercising improves sleep quality
 Avoid stimulants and alcohol prior to bed
 Limit foods high in fat and sugar – hydrate
 Establish a regular schedule and bedtime routine
 Limit screen use for two hours prior to bedtime
The Essentials of Sleep
Basics of “Good Sleep” – Sleep Overview
Sleep Requirements – Sleep Deprivation
Sleep Hygiene
Sleep Disorders
 Obstructive Sleep Apnea
 Restless Leg/Periodic Limb Movement Disorder
 REM Behavior Disorder
 Insomnia
 Narcolepsy
Obstructive Sleep Apnea
Airway During Sleep
Obstructive Sleep Apnea (OSA)
• Apnea
 Pause in breath for ≥ 10 seconds
• Hypopnea
 Flow of breath decreases by 30% of baseline
for ≥ 10 seconds associated with a fall in
oxygen saturation by 4%
3. AASM Scoring Manual Version 2.2, 2015
• SO WHAT?
Health Effects of OSA
Health Affects of Untreated OSA
• Untreated OSA =
2.5x higher risk of
accidents
• Effective treatment
cuts this risk by
70%
Health Effects of OSA
Risk Factors for OSA
• Personal history
• Family and ethnic risk
• Post menopausal women
Picture reference: https://utswim.wordpress.com/tag/pulmona
Options for Diagnosis
Home Sleep Testing
Options for Diagnosis
Polysomnography
Options for Treatment
• CPAP (continuous
positive airway
pressure) therapy
• APAP (auto-
positive airway
pressure therapy
Pre-CPAP and Post-CPAP
SAME PATIENT!
Preventative Strategies
• WEIGHT LOSS
 Diet, exercise, weight loss surgery
• Avoidance of alcohol
• Avoidance of prescription sleep aids
• Quit smoking!
Picture reference: http://users.rowan.edu/~blondi74/Expert.page.2.html
Alternative Therapies
NONSURGICAL SURGICAL
Willis-Ekbom disease
(Restless Leg Syndrome)
Diagnostic criteria:
• Urge to move (“bugs crawling up the leg”)
• Rest induced
• Gets better with activity
• Evening and nighttime worsening
Causes of Restless Legs Syndrome (RLS)
Causes:
• Genetics (up to 50%!)
• Low iron levels
• Chronic diseases
• Pregnancy
• Medication side effect
RLS TRIGGERS
Treatment of RLS
**AIM TO TREAT THE UNDERLYING CAUSE
AASM Guidelines (2012):
• Treatment is targeted to increase Dopamine in the
brain
• Medications for Parkinson's disease
pramipexole (Mirapex®), pergolide (Permax®), ropinirole
(Requip®), and a combination of carbidopa and Levodopa
(Sinemet®).
• Alternative medications:
gabapentin (Neurontin®), pregabalin (Lyrica®), opiates
Treatment of RLS
Our Favorite
Recommendations:
1. Get your ferritin and Vit D
level checked
Supplemental Iron
Supplemental Vit D
2. EXERCISE – regularly!
3. Stretch before bed
(restorative yoga)
4. Hydrate well during day
5. Magnesium
6. Tonic water
REM Behavior Disorder
REM Behavior Disorder (RBD)
• Physically acting out dreams
• Episodes occasionally in the latter part of the night.
• Noises, such as talking, laughing, shouting, emotional
outcries or even cursing
• Common movements: kicking, punching, arm flailing or
jumping from bed, in response to action-filled or violent
dreams, such as being chased or defending yourself from
an attack
RBD Risk Factors
• Being male and over 50 years old
• Medications: antidepressants (SSRIs, TCAs)
• Withdrawal from: alcohol, benzodiazepines
• Stress
• Co-morbid conditions:
 Neurodegenerative disorders, such as
Parkinson's disease, multiple system atrophy,
stroke or dementia with Lewy bodies
 Narcolepsy
 Untreated OSA (PseudoRBD)
REM Behavior Disorder Diagnosis
• Physical and neurological
exam
• Talking with your sleeping
partner
• Nocturnal sleep study
(polysomnogram)
REM Behavior Disorder Treatment
Physical safeguards – SAFE
sleep environment:
• barriers on the side of the
bed
• Move furniture
• Padding the floor near the
bed
• Removing dangerous
objects
• Separate beds
Medications:
• Melatonin
• Clonazepam
(Klonopin)
There are 84 SLEEP DISORDERS
WHICH IMPACT
100 MILLION AMERICANS
Can anyone guess the
most common sleep
complaint?
Insomnia
• Onset Insomnia - difficulty initiating sleep at the beginning of the night
• Maintenance Insomnia – The inability to stay asleep or those who
have difficulty returning to sleep or experience early morning
awakening.
• Comorbid Insomnia - Insomnia that occurs with another condition -
such as anxiety and depression. Certain medical conditions can either
cause insomnia or make a person uncomfortable at night (pain) which
may make it hard to sleep
• Further broken down into by duration….
 Acute/Primary insomnia – is brief – typically less than a month –
tends to be related to life circumstances.
 Chronic/Secondary insomnia – effects 3 nights/week for at least
3 months – can have many causes.
Inadequate or poor-quality sleep
Causes of Primary Insomnia
• Significant life stress (job loss or change, death of a loved one,
divorce, moving)
• Environmental factors like noise, light, or extreme temperatures
(hot or cold) that interfere with sleep
• Interferences in normal sleep schedule (jet lag or shift work)
Causes of Secondary Insomnia
• Conditions that cause chronic (ongoing) pain, such as
arthritis and headache disorders
• Conditions that effect heart and lungs such as asthma,
heart failure, and stroke
• Certain medications that delay or disrupt sleep
• Caffeine or stimulants
• Tobacco or alcohol
• An overactive thyroid
• Gastrointestinal disorders, such as heartburn
• Sleep disorders, such as restless legs syndrome and
sleep-related breathing problems
• Menopause and hot flashes
• Delayed and advanced sleep phase syndrome
The Insomnia Cycle
Treatment of Insomnia
• Lifestyle changes
• cognitive-behavioral therapy (CBTi) can help relieve
the anxiety linked to chronic (ongoing) insomnia. Anxiety
tends to prolong insomnia.
• Medications, prescription or OTC also can help relieve
insomnia and re-establish a regular sleep schedule.
• Treat the underlying cause (if possible).
Medications for Insomnia
• WEAK
recommendations
• Short term use
• NOT first line treatment
• Side effects can be
serious
Summit Medical Group
CBT Resource
Locations throughout Essex, Union, Morris, Warren counties with
services that include telepsychiatry
Narcolepsy
Type 1: Narcolepsy
with cataplexy
Type 2: Narcolepsy
without cataplexy
Narcolepsy
• Most patients have inherited a gene that codes for the human
leukocyte antigen (HLA) DQB1*06:02
• 25% population has this gene, but only 1% population affected by
narcolepsy
• A triggering factor that activates the immune system, such as
infection with strep
• A vulnerable age during which the immune response or some
characteristics of the brain make an autoimmune attack on the
hypocretin neurons more likely (classically younger age patients)
• PSG/MSLT required for diagnosis
Narcolepsy Treatment
• Lifestyle and home remedies including:
• Sticking to a schedule. Go to sleep and
wake up at the same time every day, including
weekends.
• Taking naps. Schedule short (20 minute)
naps at regular intervals during the day.
• Avoid nicotine and alcohol.
• Get regular exercise.
Let’s Connect the Dots
Sleep is as important as diet and exercise
only easier!
Make sleep the foundation of good health
• Set yourself up for
optimal sleep by
practicing good sleep
behaviors
• Listen to your bed
partner – they offer
insight as to nocturnal
behavior
• Think you have a sleep
disorder? Talk to a
sleep specialist!
Closing Remarks
SMG Sleep Physicians
Recommended Reading
• Sleep Smarter: 21 Essential
Strategies to Sleep Your Way
to A Better Body, Better Health,
and Bigger Success, by Shawn
Stevenson
• The Promise of Sleep, by
William Dement
• Say Goodnight to Insomnia, by
Gregg Jacobs
• Goodnight Mind, by Colleen
Carney
Thank You!
Questions?

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Can't Sleep? The ABCs of Your ZZZs

  • 1. Can’t Sleep? The ABCs of Your ZZZs Jenny H. Kim, MD, FCCP 75 E. Northfield Road Livingston NJ 07039
  • 2. The Essentials of Sleep • Basics of “Good Sleep” – Sleep Overview • Sleep Requirements – Sleep Deprivation • Sleep Hygiene • Sleep Disorders  Obstructive Sleep Apnea  Restless Legs  REM Behavior Disorder  Insomnia  Narcolepsy
  • 3. Importance of Healthy Sleep • AASM and SRS Consensus Statement1  “Adults should sleep 7 or more hours per night on a regular basis to promote optimal health” • American Thoracic Society Statement2  “Sleep is an essential biological function with major roles in recovery, energy conservation, and survival”  “It is clear that good-quality sleep is critical for good health and overall quality of life”
  • 4. The Holy Grail • A Good Night’s Sleep
  • 5. How Much Sleep is Enough?
  • 6. CDC Declares Sleep Disorders a Public Health Epidemic • In 2014 the Centers for Disease Control described sleep deprivation as so pervasive in the United States that it is considered a public health epidemic. • Research conducted by the CDC indicates that large numbers of Americans experience problems associated with lack of sufficient sleep. For example:  Almost 50 million people reported problems concentrating during the day  24 million people indicated lack of sleep interfered with driving  18 million people reported that sleep deficiency interfered with job performance.
  • 7. Third Pillar of Health • Sleep is the third of the of 4 pillars of health which include nutrition, physical fitness, sleep and stress control. • The estimated cost of lost productivity is 63.2 billion dollars a year! • A primary factor for lost productivity is presenteeism, employees showing up for work but operating at subpar levels due to sleep loss.
  • 8. Sleep Vs. Technology • The biggest sleep distraction?  1 in 2 people check right away if they wake up in the middle of the night  1 in 4 people don’t silence their phones while sleeping  1 in 10 people are awoken by their phones at least once a week
  • 10. Leptin and Ghrelin • Leptin - the appetite suppressor, is the hormone that tells your brain when you're full. • Ghrelin - the appetite increaser, is the hormone released primarily in the stomach to signal hunger to the brain. • Just two nights of restricted sleep were found to significantly impact hormones related to appetite and drive to eat, as well as self-reported hunger.
  • 11. Sleep Deprivation Getting adequate sleep is not a luxury. It is essential for good health. Sleeping less than 7 hours is associated with:
  • 12. While it still can’t cure the common cold… Getting enough sleep can help prevent catching a cold
  • 13. Drowsy Driving • National Highway Traffic Safety Administration estimates that at least 100,000 police reported crashes are the direct effect of driver fatigue • Driving after 18 hours without sleep = 2 alcoholic beverages • Driving after 24 hours without sleep = 4 alcoholic beverages
  • 14. Sleep Hygiene • Sleep hygiene - Habits and practices that are conducive to sleeping well on a regular basis.  Ensure an inviting sleep environment  Ensure exposure to light during the day  Limit daytime naps to 20-30 minutes  Exercising improves sleep quality  Avoid stimulants and alcohol prior to bed  Limit foods high in fat and sugar – hydrate  Establish a regular schedule and bedtime routine  Limit screen use for two hours prior to bedtime
  • 15. The Essentials of Sleep Basics of “Good Sleep” – Sleep Overview Sleep Requirements – Sleep Deprivation Sleep Hygiene Sleep Disorders  Obstructive Sleep Apnea  Restless Leg/Periodic Limb Movement Disorder  REM Behavior Disorder  Insomnia  Narcolepsy
  • 18. Obstructive Sleep Apnea (OSA) • Apnea  Pause in breath for ≥ 10 seconds • Hypopnea  Flow of breath decreases by 30% of baseline for ≥ 10 seconds associated with a fall in oxygen saturation by 4% 3. AASM Scoring Manual Version 2.2, 2015
  • 19. • SO WHAT? Health Effects of OSA
  • 20. Health Affects of Untreated OSA • Untreated OSA = 2.5x higher risk of accidents • Effective treatment cuts this risk by 70%
  • 21.
  • 23. Risk Factors for OSA • Personal history • Family and ethnic risk • Post menopausal women Picture reference: https://utswim.wordpress.com/tag/pulmona
  • 24. Options for Diagnosis Home Sleep Testing
  • 26. Options for Treatment • CPAP (continuous positive airway pressure) therapy • APAP (auto- positive airway pressure therapy
  • 28. Preventative Strategies • WEIGHT LOSS  Diet, exercise, weight loss surgery • Avoidance of alcohol • Avoidance of prescription sleep aids • Quit smoking! Picture reference: http://users.rowan.edu/~blondi74/Expert.page.2.html
  • 30. Willis-Ekbom disease (Restless Leg Syndrome) Diagnostic criteria: • Urge to move (“bugs crawling up the leg”) • Rest induced • Gets better with activity • Evening and nighttime worsening
  • 31. Causes of Restless Legs Syndrome (RLS) Causes: • Genetics (up to 50%!) • Low iron levels • Chronic diseases • Pregnancy • Medication side effect
  • 33. Treatment of RLS **AIM TO TREAT THE UNDERLYING CAUSE AASM Guidelines (2012): • Treatment is targeted to increase Dopamine in the brain • Medications for Parkinson's disease pramipexole (Mirapex®), pergolide (Permax®), ropinirole (Requip®), and a combination of carbidopa and Levodopa (Sinemet®). • Alternative medications: gabapentin (Neurontin®), pregabalin (Lyrica®), opiates
  • 34. Treatment of RLS Our Favorite Recommendations: 1. Get your ferritin and Vit D level checked Supplemental Iron Supplemental Vit D 2. EXERCISE – regularly! 3. Stretch before bed (restorative yoga) 4. Hydrate well during day 5. Magnesium 6. Tonic water
  • 36. REM Behavior Disorder (RBD) • Physically acting out dreams • Episodes occasionally in the latter part of the night. • Noises, such as talking, laughing, shouting, emotional outcries or even cursing • Common movements: kicking, punching, arm flailing or jumping from bed, in response to action-filled or violent dreams, such as being chased or defending yourself from an attack
  • 37. RBD Risk Factors • Being male and over 50 years old • Medications: antidepressants (SSRIs, TCAs) • Withdrawal from: alcohol, benzodiazepines • Stress • Co-morbid conditions:  Neurodegenerative disorders, such as Parkinson's disease, multiple system atrophy, stroke or dementia with Lewy bodies  Narcolepsy  Untreated OSA (PseudoRBD)
  • 38. REM Behavior Disorder Diagnosis • Physical and neurological exam • Talking with your sleeping partner • Nocturnal sleep study (polysomnogram)
  • 39. REM Behavior Disorder Treatment Physical safeguards – SAFE sleep environment: • barriers on the side of the bed • Move furniture • Padding the floor near the bed • Removing dangerous objects • Separate beds Medications: • Melatonin • Clonazepam (Klonopin)
  • 40. There are 84 SLEEP DISORDERS WHICH IMPACT 100 MILLION AMERICANS Can anyone guess the most common sleep complaint?
  • 41.
  • 42. Insomnia • Onset Insomnia - difficulty initiating sleep at the beginning of the night • Maintenance Insomnia – The inability to stay asleep or those who have difficulty returning to sleep or experience early morning awakening. • Comorbid Insomnia - Insomnia that occurs with another condition - such as anxiety and depression. Certain medical conditions can either cause insomnia or make a person uncomfortable at night (pain) which may make it hard to sleep • Further broken down into by duration….  Acute/Primary insomnia – is brief – typically less than a month – tends to be related to life circumstances.  Chronic/Secondary insomnia – effects 3 nights/week for at least 3 months – can have many causes. Inadequate or poor-quality sleep
  • 43. Causes of Primary Insomnia • Significant life stress (job loss or change, death of a loved one, divorce, moving) • Environmental factors like noise, light, or extreme temperatures (hot or cold) that interfere with sleep • Interferences in normal sleep schedule (jet lag or shift work)
  • 44. Causes of Secondary Insomnia • Conditions that cause chronic (ongoing) pain, such as arthritis and headache disorders • Conditions that effect heart and lungs such as asthma, heart failure, and stroke • Certain medications that delay or disrupt sleep • Caffeine or stimulants • Tobacco or alcohol • An overactive thyroid • Gastrointestinal disorders, such as heartburn • Sleep disorders, such as restless legs syndrome and sleep-related breathing problems • Menopause and hot flashes • Delayed and advanced sleep phase syndrome
  • 46. Treatment of Insomnia • Lifestyle changes • cognitive-behavioral therapy (CBTi) can help relieve the anxiety linked to chronic (ongoing) insomnia. Anxiety tends to prolong insomnia. • Medications, prescription or OTC also can help relieve insomnia and re-establish a regular sleep schedule. • Treat the underlying cause (if possible).
  • 47. Medications for Insomnia • WEAK recommendations • Short term use • NOT first line treatment • Side effects can be serious
  • 48. Summit Medical Group CBT Resource Locations throughout Essex, Union, Morris, Warren counties with services that include telepsychiatry
  • 49. Narcolepsy Type 1: Narcolepsy with cataplexy Type 2: Narcolepsy without cataplexy
  • 50. Narcolepsy • Most patients have inherited a gene that codes for the human leukocyte antigen (HLA) DQB1*06:02 • 25% population has this gene, but only 1% population affected by narcolepsy • A triggering factor that activates the immune system, such as infection with strep • A vulnerable age during which the immune response or some characteristics of the brain make an autoimmune attack on the hypocretin neurons more likely (classically younger age patients) • PSG/MSLT required for diagnosis
  • 51. Narcolepsy Treatment • Lifestyle and home remedies including: • Sticking to a schedule. Go to sleep and wake up at the same time every day, including weekends. • Taking naps. Schedule short (20 minute) naps at regular intervals during the day. • Avoid nicotine and alcohol. • Get regular exercise.
  • 52. Let’s Connect the Dots Sleep is as important as diet and exercise only easier! Make sleep the foundation of good health
  • 53. • Set yourself up for optimal sleep by practicing good sleep behaviors • Listen to your bed partner – they offer insight as to nocturnal behavior • Think you have a sleep disorder? Talk to a sleep specialist! Closing Remarks
  • 55. Recommended Reading • Sleep Smarter: 21 Essential Strategies to Sleep Your Way to A Better Body, Better Health, and Bigger Success, by Shawn Stevenson • The Promise of Sleep, by William Dement • Say Goodnight to Insomnia, by Gregg Jacobs • Goodnight Mind, by Colleen Carney