1) Hyperthyroidism is caused by elevated thyroid hormones due to hyperfunction of the thyroid gland. It causes a hypermetabolic state and common symptoms include weight loss, rapid heartbeat, nervousness, and goiter.
2) Hypothyroidism is a hypometabolic state caused by inadequate thyroid hormone production. Common symptoms include weight gain, fatigue, dry skin, constipation, and feeling cold.
3) Congenital hypothyroidism, known as cretinism, causes physical and mental retardation if not treated early in infancy. Screening programs help detect and treat this condition.
This document provides information on the management of patients with hyperthyroidism and hypothyroidism. It discusses the anatomy and function of the thyroid gland. It describes the different types of thyroid hormones and their regulation. It also covers the etiology, signs and symptoms, diagnosis, and treatment of both hyperthyroidism and hypothyroidism. Nursing care focuses on monitoring for symptoms, managing nutrition and mood, and ensuring patients are euthyroid before surgery to treat hyperthyroidism.
- Shelley, a 14-year-old girl, presents with symptoms of hyperthyroidism including weight loss, tremors, and an enlarged thyroid gland. Laboratory tests confirm low TSH and high free T3 and T4 levels. She is diagnosed with Graves' disease based on her symptoms and positive thyroid receptor antibodies. Graves' disease is an autoimmune disorder causing hyperthyroidism due to stimulating antibodies to the TSH receptor. Treatment involves antithyroid drugs like carbimazole to control thyroid levels and beta blockers to control symptoms of thyrotoxicosis.
- Graves disease is the most common cause of hyperthyroidism. It is an autoimmune disorder characterized by diffuse enlargement of the thyroid gland, ophthalmopathy, and dermopathy. It results from autoantibodies that stimulate the TSH receptor, causing hyperplasia of thyroid follicles.
- Hypothyroidism can be primary or secondary. Primary hypothyroidism is most often caused by Hashimoto's thyroiditis or iatrogenic ablation. It causes a hypometabolic state. Long-term untreated hypothyroidism in infants can cause cretinism, with impaired growth and mental retardation.
This document discusses the thyroid gland and its hormones, as well as hyperthyroidism and hypothyroidism. It covers the physiology and functions of thyroid hormones, causes and clinical manifestations of hyperthyroidism and hypothyroidism, diagnosis, and medical and anesthetic management considerations for patients with thyroid disorders undergoing surgery.
This document provides an overview of hypothyroidism, including:
1. It discusses the anatomy and function of the thyroid gland and describes primary causes of hypothyroidism like chronic lymphocytic thyroiditis and iodine deficiency.
2. Laboratory tests for assessing hypothyroidism are outlined, with TSH identified as the most specific indicator. Conditions that can alter TSH and thyroid hormone levels are also noted.
3. The clinical presentation of hypothyroidism is reviewed along with treatment considerations like increased thyroid hormone needs during pregnancy. Biochemical markers and expected signs of clinical improvement with treatment are summarized.
This document provides an overview of hypothyroidism, including its definition, effects on different organ systems, types, causes, investigations, and treatment. Some key points are:
- Hypothyroidism is a deficiency in thyroid hormone secretion, occurring in 2-15% of the population more commonly in women. Risk increases with age.
- It affects the cardiovascular, respiratory, renal, central nervous, neuromuscular, gastrointestinal, and hematological systems, causing decreased metabolism.
- Types include primary, central, and congenital hypothyroidism. Causes include iodine deficiency, autoimmune disease, surgery, radiation, and certain drugs.
- Investigations include thyroid function tests and antibodies
1) Hyperthyroidism is caused by elevated thyroid hormones due to hyperfunction of the thyroid gland. It causes a hypermetabolic state and common symptoms include weight loss, rapid heartbeat, nervousness, and goiter.
2) Hypothyroidism is a hypometabolic state caused by inadequate thyroid hormone production. Common symptoms include weight gain, fatigue, dry skin, constipation, and feeling cold.
3) Congenital hypothyroidism, known as cretinism, causes physical and mental retardation if not treated early in infancy. Screening programs help detect and treat this condition.
This document provides information on the management of patients with hyperthyroidism and hypothyroidism. It discusses the anatomy and function of the thyroid gland. It describes the different types of thyroid hormones and their regulation. It also covers the etiology, signs and symptoms, diagnosis, and treatment of both hyperthyroidism and hypothyroidism. Nursing care focuses on monitoring for symptoms, managing nutrition and mood, and ensuring patients are euthyroid before surgery to treat hyperthyroidism.
- Shelley, a 14-year-old girl, presents with symptoms of hyperthyroidism including weight loss, tremors, and an enlarged thyroid gland. Laboratory tests confirm low TSH and high free T3 and T4 levels. She is diagnosed with Graves' disease based on her symptoms and positive thyroid receptor antibodies. Graves' disease is an autoimmune disorder causing hyperthyroidism due to stimulating antibodies to the TSH receptor. Treatment involves antithyroid drugs like carbimazole to control thyroid levels and beta blockers to control symptoms of thyrotoxicosis.
- Graves disease is the most common cause of hyperthyroidism. It is an autoimmune disorder characterized by diffuse enlargement of the thyroid gland, ophthalmopathy, and dermopathy. It results from autoantibodies that stimulate the TSH receptor, causing hyperplasia of thyroid follicles.
- Hypothyroidism can be primary or secondary. Primary hypothyroidism is most often caused by Hashimoto's thyroiditis or iatrogenic ablation. It causes a hypometabolic state. Long-term untreated hypothyroidism in infants can cause cretinism, with impaired growth and mental retardation.
This document discusses the thyroid gland and its hormones, as well as hyperthyroidism and hypothyroidism. It covers the physiology and functions of thyroid hormones, causes and clinical manifestations of hyperthyroidism and hypothyroidism, diagnosis, and medical and anesthetic management considerations for patients with thyroid disorders undergoing surgery.
This document provides an overview of hypothyroidism, including:
1. It discusses the anatomy and function of the thyroid gland and describes primary causes of hypothyroidism like chronic lymphocytic thyroiditis and iodine deficiency.
2. Laboratory tests for assessing hypothyroidism are outlined, with TSH identified as the most specific indicator. Conditions that can alter TSH and thyroid hormone levels are also noted.
3. The clinical presentation of hypothyroidism is reviewed along with treatment considerations like increased thyroid hormone needs during pregnancy. Biochemical markers and expected signs of clinical improvement with treatment are summarized.
This document provides an overview of hypothyroidism, including its definition, effects on different organ systems, types, causes, investigations, and treatment. Some key points are:
- Hypothyroidism is a deficiency in thyroid hormone secretion, occurring in 2-15% of the population more commonly in women. Risk increases with age.
- It affects the cardiovascular, respiratory, renal, central nervous, neuromuscular, gastrointestinal, and hematological systems, causing decreased metabolism.
- Types include primary, central, and congenital hypothyroidism. Causes include iodine deficiency, autoimmune disease, surgery, radiation, and certain drugs.
- Investigations include thyroid function tests and antibodies
Hypothyroidism is a common endocrine disorder where the thyroid gland produces insufficient hormones. It affects 1.8% of the population and is more prevalent in females and the elderly. The most common cause is Hashimoto's thyroiditis which results in lymphocytic infiltration and thyroid damage. Symptoms of hypothyroidism are non-specific but include fatigue, weight gain, dry skin, and low heart rate. Treatment involves lifelong thyroid hormone replacement therapy with levothyroxine to normalize thyroid levels. Special care is needed in pregnancy, myxedema coma, and avoiding overtreatment.
Medical information and significance about Hypothyroidism, thyroiditis and Ca...habituallawn064
1. Hypothyroidism is caused by thyroid hormone deficiency and can occur due to problems with the thyroid gland itself or with the pituitary or hypothalamus. Common causes include Hashimoto's thyroiditis, surgery or radiation treatment of the thyroid, and iodine deficiency.
2. Symptoms of hypothyroidism are wide-ranging and affect nearly every organ system. They include fatigue, dry skin, joint pain, constipation, weight gain, depression, and increased cholesterol levels.
3. Treatment involves lifelong thyroid hormone replacement therapy, typically with levothyroxine to replace T4, with dosages tailored to the individual to relieve symptoms and lower elevated TSH levels into the normal
Hyperthyroidism is a condition where the thyroid gland is overactive and produces too much thyroid hormone, leading to accelerated metabolism. It can be caused by Graves' disease in most cases. Symptoms include nervousness, rapid heartbeat, weight loss, and eye problems. Treatment involves anti-thyroid medications, radioactive iodine, surgery or beta blockers to reduce thyroid hormone levels and symptoms.
Hashimoto's thyroiditis and subacute thyroiditis are the most common causes of primary hypothyroidism. Hashimoto's is an autoimmune disorder characterized by elevated TSH and the presence of anti-thyroid antibodies. Subacute thyroiditis causes a transient hypothyroid phase due to thyroid hormone release rather than increased synthesis, with low radioactive iodine uptake and no antibodies present. Graves' disease, the most common cause of hyperthyroidism, results from TSH receptor antibodies that mimic TSH and stimulate increased thyroid hormone production.
This document discusses thyrotoxicosis and hyperthyroidism. It begins by covering thyroid physiology including iodine metabolism and thyroid hormone synthesis. It then discusses the causes and clinical manifestations of Graves' disease (diffuse toxic goiter), toxic multinodular goiter, and toxic adenoma. Diagnostic tests and treatment options including antithyroid drugs, radioactive iodine therapy, and surgery are described for hyperthyroidism. Thyroid storm, a medical emergency, is also summarized.
This document provides an overview of thyrotoxicosis, including its epidemiology, pathophysiology, causes, clinical manifestations, diagnosis, and management. Some key points:
- Thyrotoxicosis is defined as thyroid hormone excess and can be caused by hyperthyroidism, thyroiditis, or excess hormone ingestion. The major causes of hyperthyroidism are Graves' disease, toxic multinodular goiter, and toxic adenomas.
- Clinical manifestations depend on severity and duration of thyrotoxicosis, and include symptoms like palpitations, sweating, weight loss as well as signs like goiter, tremor, eye changes. Diagnosis involves testing thyroid function through TSH,
Hyperthyroidism refers to overactivity of the thyroid gland resulting in excessive secretion of thyroid hormones. The thyroid gland produces thyroid hormones which regulate metabolism. Common causes of hyperthyroidism include Graves' disease, multinodular goiter, and thyroiditis. Signs and symptoms include nervousness, palpitations, heat intolerance, tremors, and weight loss. Diagnosis involves thyroid function tests and scans. Treatment options include anti-thyroid medications, radioactive iodine, and surgery. Nursing care focuses on managing nutrition, activity tolerance, risk for injury, hyperthermia, and social interaction issues.
This document summarizes information about the thyroid gland and thyroid disorders. It describes the functions of thyroid hormones T3 and T4, the signs and symptoms of hyperthyroidism (thyrotoxicosis) and hypothyroidism, and the various causes of each condition. It also outlines the management and treatment approaches for hyperthyroidism and hypothyroidism, including anti-thyroid medications, radioactive iodine therapy, surgery, and levothyroxine replacement for hypothyroidism. Complications of treatment are also discussed.
This document discusses hyperthyroidism and its management. It begins with definitions of hyperthyroidism and thyrotoxicosis. It then discusses the prevalence, anatomy, physiology and causes of hyperthyroidism. The clinical manifestations involving multiple body systems are explained in detail. Diagnostic tests including blood tests, ultrasound and radioactive iodine uptake scans are outlined. Finally, the medical management including antithyroid drugs, radioactive iodine therapy and surgery are summarized.
Hyperthyroidism and hypothyroidism are disorders caused by excess or deficiency of thyroid hormones. Hyperthyroidism causes symptoms of hypermetabolism like weight loss, heat intolerance, palpitations and anxiety. Hypothyroidism causes symptoms of slowed metabolism like fatigue, cold intolerance, dry skin and constipation. Both disorders affect multiple body systems and can be treated with medications, radioactive iodine or surgery to restore normal thyroid function.
This document discusses a case of hyperthyroidism in a 39-year-old female presenting with nervousness, anxiety, palpitations, diarrhea, and weight loss. On examination, she had a heart rate of 110 bpm, tremor, increased reflexes, and an enlarged thyroid. Laboratory tests found high free T3 and T4, low TSH, and positive thyroid stimulating immunoglobulins, consistent with a diagnosis of Graves' disease. Graves' disease is an autoimmune disorder causing hyperthyroidism through thyroid stimulating antibodies. If left untreated, hyperthyroidism can progress to a thyroid storm, a life-threatening condition of severe hypermetabolism.
Diagnosis and treatment of hypothyroidism.pptxvivianOkoli1
Hypothyroidism is a common endocrine disorder where the thyroid gland does not produce enough hormones. It can be caused by iodine deficiency, autoimmune disease, or drugs/radiation affecting the thyroid. Symptoms are often subtle and vary in children, women, and elderly people. Laboratory tests show low thyroid hormones and high TSH. Treatment is with levothyroxine replacement to restore hormone levels, with dose adjustments over time based on symptoms and follow-up tests. In severe cases, myxoedema coma requires emergency treatment in hospital.
The pituitary gland is a small structure located at the base of the brain that secretes hormones controlling other endocrine glands. Hypopituitarism occurs when the pituitary gland fails to secrete sufficient hormones, causing weight loss, hair loss, and hypometabolism if hormones are not replaced. Pituitary tumors can cause gigantism, acromegaly, or Cushing's syndrome depending on location and are assessed using imaging and hormone level tests. Surgical removal of the pituitary treats tumors but requires lifelong hormone replacement.
This document summarizes thyroid diseases and evaluation of thyroid nodules. It discusses the peripheral action of thyroid hormones, thyroiditis conditions including Hashimoto's, subacute, and Riedel's, hyperthyroidism including Graves' disease and toxic nodular goiter, evaluation of thyroid nodules including risk factors and initial workup, and treatment options for hyperthyroidism such as antithyroid medications, radioactive iodine, and surgery.
Thyroid disorders -Study material for nursing studentsloritacaroline
The document discusses thyroid disorders, including hyperthyroidism and hypothyroidism. It describes the thyroid gland and the hormones it produces. Hyperthyroidism occurs when the thyroid gland is overactive and produces too much thyroid hormone. Its causes include Graves' disease and excess iodine intake. Hypothyroidism is caused by an underactive thyroid gland producing too little hormone. The signs, symptoms, complications, diagnosis and treatment of both conditions are explained in detail. The role of nurses in caring for patients with thyroid disorders is also outlined.
Hypothyroidism is caused by a deficiency of thyroid hormones. The most common causes are autoimmune destruction of the thyroid gland (Hashimoto's disease) and treatment for hyperthyroidism. Symptoms include fatigue, weight gain, dry skin and hair, and slow reflexes. It is diagnosed based on elevated thyroid stimulating hormone (TSH) levels. Treatment involves replacing thyroid hormones with small increasing doses of thyroxine. Non-thyroidal illness can also affect thyroid hormone levels but patients are clinically euthyroid and do not require treatment.
Diseases of the thyroid gland can cause enlargement known as goiter. Simple goiter is caused by chronic lack of thyroid hormones leading to compensatory TSH elevation and thyroid enlargement. Toxic goiter or hyperthyroidism occurs when the thyroid overproduces hormones. Graves' disease is the most common cause of primary hyperthyroidism due to autoantibodies stimulating the thyroid. Secondary hyperthyroidism has other underlying thyroid pathology causing excess hormone production. Symptoms of hyperthyroidism include tremors, rapid heart rate, weight loss and eye protrusion. Treatment involves antithyroid drugs, beta blockers, radioiodine therapy or surgery.
This document presents a case study of a 34-year-old woman with hypothyroidism. Her symptoms include fatigue, blurred vision, vertigo, cold intolerance, menorrhagia, and constipation. On examination, she appears thin, pale, and has delayed reflexes. Laboratory tests show elevated TSH and low T3 and T4, confirming hypothyroidism. Ultrasound reveals an enlarged liver and thyroid nodule. The document then discusses hypothyroidism, its causes, clinical manifestations, diagnosis, and management, including the use of levothyroxine treatment and monitoring of TSH levels. It also covers special populations like pregnant women, the elderly, and cases of myxedema
The document discusses hyperthyroidism and hypothyroidism.
Hyperthyroidism results from excess thyroid hormone in the blood and common causes include Graves' disease, toxic adenomas, and thyroiditis. Symptoms include nervousness, rapid heart rate, weight loss, and eye changes. Diagnosis involves thyroid function tests and treatment options are anti-thyroid medications, radioactive iodine, beta blockers, or surgery.
Hypothyroidism is caused by an underactive thyroid gland and risks factors include older age and autoimmune diseases. Symptoms are fatigue, weight gain, dry skin and constipation. Diagnosis is via thyroid hormone levels and treatment is thyroid hormone replacement medication.
GENETICS DISORDERS thelesemia.pptx from robbindr shahida
The document discusses the genetic disorders of thalassemia. It explains that thalassemia is caused by mutations that decrease the synthesis of the alpha or beta globin chains, leading to anemia. Specifically, it describes how beta thalassemia is caused by deficient beta chain synthesis and alpha thalassemia by deficient alpha chain synthesis. The clinical presentations of different forms of alpha and beta thalassemia are explained, ranging from mild anemia in trait forms to severe transfusion-dependent anemia or hydrops fetalis in major forms.
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Hypothyroidism is a common endocrine disorder where the thyroid gland produces insufficient hormones. It affects 1.8% of the population and is more prevalent in females and the elderly. The most common cause is Hashimoto's thyroiditis which results in lymphocytic infiltration and thyroid damage. Symptoms of hypothyroidism are non-specific but include fatigue, weight gain, dry skin, and low heart rate. Treatment involves lifelong thyroid hormone replacement therapy with levothyroxine to normalize thyroid levels. Special care is needed in pregnancy, myxedema coma, and avoiding overtreatment.
Medical information and significance about Hypothyroidism, thyroiditis and Ca...habituallawn064
1. Hypothyroidism is caused by thyroid hormone deficiency and can occur due to problems with the thyroid gland itself or with the pituitary or hypothalamus. Common causes include Hashimoto's thyroiditis, surgery or radiation treatment of the thyroid, and iodine deficiency.
2. Symptoms of hypothyroidism are wide-ranging and affect nearly every organ system. They include fatigue, dry skin, joint pain, constipation, weight gain, depression, and increased cholesterol levels.
3. Treatment involves lifelong thyroid hormone replacement therapy, typically with levothyroxine to replace T4, with dosages tailored to the individual to relieve symptoms and lower elevated TSH levels into the normal
Hyperthyroidism is a condition where the thyroid gland is overactive and produces too much thyroid hormone, leading to accelerated metabolism. It can be caused by Graves' disease in most cases. Symptoms include nervousness, rapid heartbeat, weight loss, and eye problems. Treatment involves anti-thyroid medications, radioactive iodine, surgery or beta blockers to reduce thyroid hormone levels and symptoms.
Hashimoto's thyroiditis and subacute thyroiditis are the most common causes of primary hypothyroidism. Hashimoto's is an autoimmune disorder characterized by elevated TSH and the presence of anti-thyroid antibodies. Subacute thyroiditis causes a transient hypothyroid phase due to thyroid hormone release rather than increased synthesis, with low radioactive iodine uptake and no antibodies present. Graves' disease, the most common cause of hyperthyroidism, results from TSH receptor antibodies that mimic TSH and stimulate increased thyroid hormone production.
This document discusses thyrotoxicosis and hyperthyroidism. It begins by covering thyroid physiology including iodine metabolism and thyroid hormone synthesis. It then discusses the causes and clinical manifestations of Graves' disease (diffuse toxic goiter), toxic multinodular goiter, and toxic adenoma. Diagnostic tests and treatment options including antithyroid drugs, radioactive iodine therapy, and surgery are described for hyperthyroidism. Thyroid storm, a medical emergency, is also summarized.
This document provides an overview of thyrotoxicosis, including its epidemiology, pathophysiology, causes, clinical manifestations, diagnosis, and management. Some key points:
- Thyrotoxicosis is defined as thyroid hormone excess and can be caused by hyperthyroidism, thyroiditis, or excess hormone ingestion. The major causes of hyperthyroidism are Graves' disease, toxic multinodular goiter, and toxic adenomas.
- Clinical manifestations depend on severity and duration of thyrotoxicosis, and include symptoms like palpitations, sweating, weight loss as well as signs like goiter, tremor, eye changes. Diagnosis involves testing thyroid function through TSH,
Hyperthyroidism refers to overactivity of the thyroid gland resulting in excessive secretion of thyroid hormones. The thyroid gland produces thyroid hormones which regulate metabolism. Common causes of hyperthyroidism include Graves' disease, multinodular goiter, and thyroiditis. Signs and symptoms include nervousness, palpitations, heat intolerance, tremors, and weight loss. Diagnosis involves thyroid function tests and scans. Treatment options include anti-thyroid medications, radioactive iodine, and surgery. Nursing care focuses on managing nutrition, activity tolerance, risk for injury, hyperthermia, and social interaction issues.
This document summarizes information about the thyroid gland and thyroid disorders. It describes the functions of thyroid hormones T3 and T4, the signs and symptoms of hyperthyroidism (thyrotoxicosis) and hypothyroidism, and the various causes of each condition. It also outlines the management and treatment approaches for hyperthyroidism and hypothyroidism, including anti-thyroid medications, radioactive iodine therapy, surgery, and levothyroxine replacement for hypothyroidism. Complications of treatment are also discussed.
This document discusses hyperthyroidism and its management. It begins with definitions of hyperthyroidism and thyrotoxicosis. It then discusses the prevalence, anatomy, physiology and causes of hyperthyroidism. The clinical manifestations involving multiple body systems are explained in detail. Diagnostic tests including blood tests, ultrasound and radioactive iodine uptake scans are outlined. Finally, the medical management including antithyroid drugs, radioactive iodine therapy and surgery are summarized.
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This document discusses a case of hyperthyroidism in a 39-year-old female presenting with nervousness, anxiety, palpitations, diarrhea, and weight loss. On examination, she had a heart rate of 110 bpm, tremor, increased reflexes, and an enlarged thyroid. Laboratory tests found high free T3 and T4, low TSH, and positive thyroid stimulating immunoglobulins, consistent with a diagnosis of Graves' disease. Graves' disease is an autoimmune disorder causing hyperthyroidism through thyroid stimulating antibodies. If left untreated, hyperthyroidism can progress to a thyroid storm, a life-threatening condition of severe hypermetabolism.
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Hypothyroidism is a common endocrine disorder where the thyroid gland does not produce enough hormones. It can be caused by iodine deficiency, autoimmune disease, or drugs/radiation affecting the thyroid. Symptoms are often subtle and vary in children, women, and elderly people. Laboratory tests show low thyroid hormones and high TSH. Treatment is with levothyroxine replacement to restore hormone levels, with dose adjustments over time based on symptoms and follow-up tests. In severe cases, myxoedema coma requires emergency treatment in hospital.
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Hypothyroidism is caused by a deficiency of thyroid hormones. The most common causes are autoimmune destruction of the thyroid gland (Hashimoto's disease) and treatment for hyperthyroidism. Symptoms include fatigue, weight gain, dry skin and hair, and slow reflexes. It is diagnosed based on elevated thyroid stimulating hormone (TSH) levels. Treatment involves replacing thyroid hormones with small increasing doses of thyroxine. Non-thyroidal illness can also affect thyroid hormone levels but patients are clinically euthyroid and do not require treatment.
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hypo and hyper thyroidism final lecture.pptx
1. P R O F. D R . N A S E E R
H O D P A T H O L O G Y
THYROID
(HYPOTHYROIDISM)
2. HYPOTHYROIDISM
• It is a condition caused by structural or functional
derangement that interferes with the production of the
thyroid hormone.
• This is a common disorder.
• Prevalence increases with age.
• 10 folds more common in women than men.
• Defect may occur anywhere in hypothalamus – pituitary-
thyroid axis.
3. It is of two types:
• Primary (intrinsic abnormality in thyroid)
• Secondary (it is a result of pituitary and hypothalamus disease)
PRIMARY HYPOTHYROIDISM: can be,
1. congenital: it is a result of iodine deficiency in diet, other rare
forms include
* inborn error of metabolism that is any step leading to thyroid
hormone synthesis may be defective as ,
A. Iodine transport to thyrocytes for organification of iodine.
B. Binding of iodine to tyrosine residue of storage protein
thyroglobulin.
C. Iodotyrosine coupling to form hormonally active T3 and T4.
In rare stances complete absence of parenchyma (thyroid
agenesis)OR gland may be greatly reduced (hypoplasia).
4. 2. AUTO IMMUNE HYPOTHYROIDSM:
• Most common cause of hypothyroidism in iodine
sufficient areas of the world.
• Vast majority of cases of autoimmune hypothyroidism
are due to Hashimoto thyroiditis.
• Circulating auto antibodies including antimicrosomal
antithyroid peroxidase and antithyroglobulin antibodies
are found in this disorder.
• The thyroid is typically enlarged (goitrous).
5. 3. IOTROGENIC HYPOTHYROIDISM:
• It is caused by surgical or radiation induced ablation,
1. thyroidectomy for hyperthyroidism can lead to
hypothyroidism.
2. the gland can also be ablated by radiation by radio
iodine administration for the treatment of hypothyroidism
or exogenous irradiation such as external radiation
therapy to neck.
3. drugs given intentionally to decrease thyroid secretion
(for e.g methimezole and propylthiouracil can also cause
acquired hypothyroidism, agents use to treat non thyroid
condition for e.g lithium , p-amino salicylic acid can cause
hypothyroidism.)
6. 3. SECONDARY HYPOTHYROIDISM:
• Deficiency of TSH or TRH due to pituitary tumor of post
partum pituitary necrosis or trauma.
• hypothalamic damage from tumor, trauma or irradiation
therapy.
7. CRETINISM
• Refers to hypothyroidism that develops in infancy or early childhood.
• They are unfortunately mentally retarded.
• CLINICAL FEATURES:
• Impaired development of skeletal system and central nervous system
manifests severe mental retardation, short stature, coarse facial
features, protruding tongue and umbilical hernia.
• Mental retardation is related to thyroid deficiency in utero as T3 and T4
cross placenta is critical for fetal brain development.
• If maternal thyroid deficiency is before he development of fetal thyroid
gland , mental retardation is severe.
• While thyroid deficiency later in pregnancy after fetal thyroid is
functional does not effect normal brain development.
8. MYXEDEMA
• It develops in older child or adults.
• Myxedema is marked by,
• Slowing of physical and mental activity.
• Initial symptoms include generalized fatigue, apathy, mental
sluggishness.
• Speech and intellectual functions are slowed.
• Patient of myxedema are listless cold intolerant and frequently
overweight.
• Decrease sympathetic activity has constipation and decrease
sweating.
• Reduced cardiac output leads to shortness of breath and
decrease exercise capacity.
• In addition hypothyroidism promote atherogenic profile for e.g
increased in cholesterol and LDL levels contributes to increase
cardiovascular mortality.
9. • Histologically there is a increased accumulation of
glycosaminoglycan's and hyaluronic acid in subcutaneous
tissue of skin and other viscera results in non pitting
edema, broadening and coarsening of facial features.
• Enlargement of tongue and deepening of voice.
• Unexplained Increased in weight or hypocholesteremia
should be assessed for potential hypothyroidism.
• Measurement of TSH levels is the most sensitive screening
test for this disorder.
• TSH level is increased in primary hypothyroidism.
• TSH level is not increased in persons with hypothyroidism
due to primary hypothalamic or pituitary disease.
• T4 is decreased with individuals with hypothyroidism.
10. HYPERTHYROIDISM
. it is due to excessive release of thyroid hormone.
.THYROTOXICOSIS: it is a hypermetabolic state caused by elevated
circulating levels of T3 T4.
CAUSES:
Excessive release of pre form thyroid hormone in e.g thyroiditis or from
extra thyroid source.
PRIMARY HYPERTHYROIDISM : hyperthyroidism arising from intrinsic
thyroid abnormality.
SECONDARY HYPERTHYROIDISM: arising from process outside
thyroid as TSH secreting pituitary tumors.
Three most common causes of thyrotoxicosis are,
1. Diffuse hyperplasia. (graves disease responsible for 80 % cases)
2. Hyperfunction of multinodular goiter
3. Hyperfunctional thyroid adenoma.
11. CLINICAL COARSE:
• It is hypermetabolic state, induced excess thyroid hormone and over
activity of sympathetic nervous system.
• Excessive thyroid causes in crease in metabolic rate, ski tends to be
soft, warm, flushed due to increased blood flow and peripheral
vasodilation,
A. heat intolerance is common
B. sweating is increased
C. weight loss despite increase in appetite.
CARDIAC MANIFESTATION : are the most constant and earliest
feature.
• Elevated cardiac contractility and increased cardiac output as there
is increased peripheral oxygen requirement so,
A. tachycardia
B. palpitation
C. cardiomegaly
D. arrhythmias (atrial fibrillation is more common in elderly patient)
E. congestive heart failure.
THYROTOXIC CARDIOMYOPATHY: its reversible left ventricular
dysfunction leads to low cardiac output and heart failure.
12. OVERACTIVITY OF SYMPATHETIC NERVOUS
SYSTEM: produce,
A. tremors
B. hyperactivity
C .emotional liability
D .Anxiety
E. inability to concentrate
F. insomnia
Proximal muscle weakness and decrease muscle mass.
GIT DISTURBANCES, hyper motility, diarrhea and
malabsorption.
13. OCCULAR CHANGES: these changes often call attention to
hyperthyroidism.
A. wide staring gazed
B. lid lag due to sympathetic overs stimulation of superior
tarsals muscle.
C. proptosis (it occurs only graves disease)
SKELETAL SYSTEM : thyroid hormone stimulates bone
resorption results in,
• Osteoporosis with increased risk of fracture.
• Atrophy of skeletal muscle with fatty infiltrations.
• Minimal liver enlargement due to fatty infiltration.
• Generalized lymphoid hyperplasia and lymph adenopathy
in patient with graves disease.
14. THYROID STORM: It refers to abrupt onset of severe
hyperthyroidism,
• Occurs in patient with graves disease.
• Probably results from acute elevation of catecholamine's
during infections, surgery, cessation of ant thyroid drugs
or any stress .
• Patient id often febrile with tachycardia , out of proportion
of fever.
• Thyroid storm is a medical emergency, a significant
number of untreated patient die of arrhythmias.
APATHETIC HYPERTHYROIDISM:
• It refers to thyrotoxicosis in older adults in whom
comorbidities may blunt the features of hyperthyroidism.
15. DIAGNOSIS:
• TSH concentration is the most useful screening test for
hyperthyroidism.
• TSH levels are decreased even at the earliest stage.
• Confirm with the measurement of free T4 which is
increased.
SECONDARY HYPERTHYROIDISM:
(PITUITATRY ASSOCIATION)
• TSH levels are either normal or raised.
• TSH levels are determined after injection of thyrotropin
releasing hormone (TRH) is used.
• Normal rise in TSH after administration of TRH exclude
secondary hyperthyroidism.
16. • Once diagnosis of thyrotoxicosis is confirmed by TSH
assay and free thyroid hormone levels, measurement of
radioactive iodine uptake can determine the etiology.
1. diffuse increase uptake in whole gland means graves
disease.
2. increase uptake in solitary nodule indicates toxic
adenoma.
3. decrease uptake indicates thyroiditis.
17. THERAPEUTIC OPTIONS:
1. beta blockers to control the symptoms induced by
increased adrenergic tone.
2. Athionamide to block the new hormone synthesis.
3. iodine solutions to block the release of thyroid hormone.
4. thyroid hormones and agents that inhibit the peripheral
conversion of t4 to t3.
5. Radio iodine is incorporated to thyroid tissue resulting in
ablation of thyroid function over a period six to eighteen
weeks.