This document discusses the management of Cytomegalovirus (CMV) infection in patients with inflammatory bowel disease (IBD). It begins by presenting a case study of an 18-year-old man diagnosed with CMV-positive ulcerative colitis. It then provides background on CMV, including how it is transmitted, risk factors for reactivation, and definitions of CMV infection and disease. The document discusses diagnostic guidelines and techniques for detecting CMV in IBD patients. It explores the pathophysiology of CMV infection in IBD, prevalence and clinical findings of CMV colitis in Crohn's disease and ulcerative colitis, and influence of medical treatments on CMV reactivation. It concludes by