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CMV in Kidney Transplant Arun Chawla, MD  Hofstra North Shore –LIJ School of Medicine
What is CMV?? ,[object Object],[object Object],[object Object],[object Object]
Why should we know CMV?? ,[object Object],[object Object],[object Object],[object Object],[object Object]
CMV infection ,[object Object],[object Object],[object Object],[object Object],[object Object]
CMV Disease ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Also… ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Types of CMV Infection ,[object Object],[object Object],[object Object],[object Object]
Risk Factors ,[object Object],[object Object],[object Object],Correlation of CMV DNA levels with response to antiviral therapy in cardiac and renal allograft recipients.Toyoda M et al Transplantation 1997 Apr 15;63(7):957-63.
Donor Recipient Type D+ R- primary D- R+ reactivation D+ R+ superinfection D- R- risk with exposure
Prevention ,[object Object],[object Object],[object Object],[object Object],Meta-analysis: the efficacy of strategies to prevent organ disease by CMV in solid organ transplant recipients. Kalil AC et al Ann Intern Med. 2005 Dec 20;143(12):870-80.
Agents for Prophylaxis ,[object Object],[object Object],[object Object],[object Object],Efficacy and safety of valganciclovir vs. oral ganciclovir for prevention of CMV disease in solid organ transplant recipients. Paya C et al. J Transplant 2004 Apr;4(4):611-20.
Choice and duration ,[object Object],[object Object],[object Object],[object Object]
CMV status & HLA-DR matching ,[object Object],[object Object],[object Object]
Preemptive strategy ,[object Object],[object Object],[object Object],[object Object],[object Object]
Diagnosis of CMVD ,[object Object],[object Object],[object Object]
Treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Oral valganciclovir is noninferior to intravenous ganciclovir for the treatment of cytomegalovirus disease in solid organ transplant recipients. Asberg A et al. J Transplant. 2007 Sep;7(9):2106-13
Duration of t/t ,[object Object],[object Object],[object Object],[object Object],[object Object]
Thank You  …………….

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CMV in Organ Transplantation

  • 1. CMV in Kidney Transplant Arun Chawla, MD Hofstra North Shore –LIJ School of Medicine
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  • 10. Donor Recipient Type D+ R- primary D- R+ reactivation D+ R+ superinfection D- R- risk with exposure
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  • 19. Thank You …………….