This presentation is about aniridia ,signs and symptoms of aniridia and also about the treatment options about aniridia

1. ANIRIDIA

2. • Absence of iris
• Bilateral
• Congenital or penetrating injury
PREVELANCE:
• 1 in 50,000 – 1,00,000

3. CAUSES
• Occurs in 12th to 14th week of pregnancy
• Due to mutation in the short arm of
chromosome 11 and affects PAX6 gene

4. ASSOCIATION
• Aniridia with cornea ,iris ,lens ,optic
nerve(hypoplasia) ,retina(foveal
hypoplasia),nystagmus
• WAGR SYNDROME
• Millers syndrome
• Gillespie syndrome

5. • Millers syndrome with kidner tumour called
nephroblastoma
• WAGR syndrome
W - wilm’s tumour
A -aniridia
G - genitourinary abnormalities
R - mental retardation
• Gillespie syndrome is the combination of
aniridia ,mental retardation ,balance
problem(ataxia)

6. SYMPTOMS
• Reduction in the sharpnesss of vision
• Photophobia
• Myopia – 64%
• Amblyopia – 37%

7. TREATMENT
• Regular eye exam to asses and screen for
glasses ,glaucoma and cataract
• If glaucoma develops treatment typically eye
drops, but may require surgery
• If cataract develops removal of lens and IOL
implantation

8. • Corneal problem – artificial tears, oinment
• Limbal stem cell transplant may improve
corneal scarring
• Recent development is a black artificial iris-
lens implant i.e sometimes placed after
cataract surgery