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DEVELOPMENT OF METENCEPHALON
MOTOR AND SENSORY NUCLEI
 Som. efferent: CN VI
 SVE: motor nuclei of CN V and CN VII

 GVE: Sublingual and submandibular gland

 …………………………

 SA: CN VIII,CN V

 SVA:

 GVA:
CEREBEELUM
RHOMBIC LIPS

 Dorsolateral part of alar plate bends medially to
  form rhombic lips
 POSITION:

 Caudally: widely seperated

 Just below the mesencephalon: approach each
  other in the midline
CEREBELLAR PLATE
   With further deepening of pontine flexure, rhombic
    lips are compressed craniocaudally to form
    cerebellar plate
 VERMIS: a midline tubercle appear on c.plate
 CEREBELLAR HEMISPHERES: one on each side
  of vermis
 TRANSVERSE FISSURE: seperates nodule from
  vermis and flocculus from cerebellar hemispheres
LAYERS OFCEREBELLUM
 Initially:
 Neuroepithelial layer, Mantle layer, Marginal layer

 EXTERNAL GRANULAR LAYER OF
  CEREBELLUM:
A number of cells produced from neuroepi layer
migrate towards the surface and form this layer.
+ Cells of this layer retain their ability to divide and
form a proliferative zone in cerebellum
 GRANULE CELLS: cells of ext.granular layer form
  a variety of cells which migrate towards
  differentiating purkinje cells to form granule cells.
 BASKET AND STELLATE CELLS: formed in white
  matter of sp.cord
CELLS OF CEREBELLAR CORTEX(REACH
THEIR DEFINITIVE SIZE AFTER BIRTH)

 Purkinje cells
 Golgi II cells

 External granular cells
DEEP NUCLEI(REACH THEIR FINAL DEFINITIVE
POSITION BEFORE BIRTH)

   Dentate nucleus

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Development of metencephalon

  • 2. MOTOR AND SENSORY NUCLEI  Som. efferent: CN VI  SVE: motor nuclei of CN V and CN VII  GVE: Sublingual and submandibular gland  …………………………  SA: CN VIII,CN V  SVA:  GVA:
  • 4. RHOMBIC LIPS  Dorsolateral part of alar plate bends medially to form rhombic lips  POSITION:  Caudally: widely seperated  Just below the mesencephalon: approach each other in the midline
  • 5. CEREBELLAR PLATE  With further deepening of pontine flexure, rhombic lips are compressed craniocaudally to form cerebellar plate
  • 6.  VERMIS: a midline tubercle appear on c.plate  CEREBELLAR HEMISPHERES: one on each side of vermis  TRANSVERSE FISSURE: seperates nodule from vermis and flocculus from cerebellar hemispheres
  • 7. LAYERS OFCEREBELLUM  Initially:  Neuroepithelial layer, Mantle layer, Marginal layer  EXTERNAL GRANULAR LAYER OF CEREBELLUM: A number of cells produced from neuroepi layer migrate towards the surface and form this layer. + Cells of this layer retain their ability to divide and form a proliferative zone in cerebellum
  • 8.  GRANULE CELLS: cells of ext.granular layer form a variety of cells which migrate towards differentiating purkinje cells to form granule cells.  BASKET AND STELLATE CELLS: formed in white matter of sp.cord
  • 9. CELLS OF CEREBELLAR CORTEX(REACH THEIR DEFINITIVE SIZE AFTER BIRTH)  Purkinje cells  Golgi II cells  External granular cells
  • 10. DEEP NUCLEI(REACH THEIR FINAL DEFINITIVE POSITION BEFORE BIRTH)  Dentate nucleus