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Neural tube defects

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NTDs

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Neural tube defects

  1. 1. NEURAL TUBE DEFECTS
  2. 2. CAUSES  Abnormal closure of neural folds  Teratogens  Multifactorial(involving both genetic and environmental factors)
  3. 3. SPINA BIFIDA  General term used for NTDs in spinal region  Vertebral arches split apart  Underlying nervous tissue may or may not be involved
  4. 4. SPINA BIFIDA OCCULTA AND CYSTICA Vertbral arches defective defective Skin Patch of hair over the defect Protrusion in the form of sac Underlying neural tissue Not involved Involved alongwith meninges Region in which they are most common Lumbosacral Lumbosacral region
  5. 5. S.B with myeloschisis/Rachi schisis S.B. with Meningeocoele S.B with Meningeomyelocoe le Failure of neural folds to elevate Only meninges involved Underlying nervous tissue also involved
  6. 6. WHY DOE S HY DROCE PHALUS DE VE L OP IN SP. BIFIDA CYSTICA? Spinal cord is tethered to vertebral column and as it elongates,it pulls the cerebellum through the foramen magnum thus cutting off the flow of CSF and producing hydrocephalus.
  7. 7. TREATMENT  400mg of folic acid is given 2-3 months before pregnancy and continued throughout the gestation

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