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LINKAGE AND CROSSING OVER
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Mendel's Law of Independent Assortment   Allele pairs separate independently during the formation of gametes. This means that traits are transmitted to offspring independently of one another.
Dihybrid cross - phenotypes
Independent assortment An Interpretation from the Dihybrid cross   ,[object Object],[object Object],[object Object]
Discovery of Linkage ,[object Object]
Bateson and Punnett also studied peas: Flower Color: P = purple p = red Pollen seed shape: L = long l = round True Breeding lines: PPLL   x ppll P PpLl F1 Phenotype Number   Exp Ratio Exp Number Purple long 284 9 215 Purple round 21 3   71 Red long   21 3   71 Red round 55 1   24 What is going on???? Crosses produced a deviation from the predicted  Mendelian independent assortment ratios.
[object Object]
Test cross F1 to double recessive: Parents PpLl  X  ppll Gametes PL pl Pl pL pl Expect 1:1:1:1 ratio of phenotypes Bateson and Punnett observed 7:1:1:7 Some gamete types more common that others…but why???
[object Object],[object Object]
[object Object],[object Object]
MORGAN’S EXPERIMENTS ,[object Object],[object Object],[object Object]
Morgan’s experimental crosses of white-eye and miniature-wing variants of  Drosophila melanogaster ,[object Object],[object Object]
What is Linkage? ,[object Object],[object Object],[object Object],[object Object],[object Object]
Morgan and Crossing Over ,[object Object],[object Object]
Process of Recombination ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
Recombination Process
Peter J. Russell,  iGenetics : Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. Mechanism of crossing-over
No Linkage: Independent Assortment
Linkage without Recombination
Linkage with Recombination
Linkage Mapping ,[object Object],[object Object],[object Object],[object Object]
Detecting Linkage through Testcrosses ,[object Object],[object Object],[object Object],[object Object]
Sturtevant and Mapping ,[object Object],[object Object],[object Object],[object Object]
Sturtevant’s Interpretation ,[object Object]
Single Crossovers: Non-crossover (Parental) and Crossover (Recombinant) Gametes What is the maximum % recombination?
Map Units ,[object Object],[object Object],[object Object],[object Object],[object Object]
III. Three-Point Mapping ,[object Object],[object Object],[object Object]
Genetic Map of  Drosophila melanogaster
Interference ,[object Object],[object Object],[object Object]

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Linkage and crossing over

  • 2.
  • 3. Mendel's Law of Independent Assortment Allele pairs separate independently during the formation of gametes. This means that traits are transmitted to offspring independently of one another.
  • 4. Dihybrid cross - phenotypes
  • 5.
  • 6.
  • 7. Bateson and Punnett also studied peas: Flower Color: P = purple p = red Pollen seed shape: L = long l = round True Breeding lines: PPLL x ppll P PpLl F1 Phenotype Number Exp Ratio Exp Number Purple long 284 9 215 Purple round 21 3 71 Red long 21 3 71 Red round 55 1 24 What is going on???? Crosses produced a deviation from the predicted Mendelian independent assortment ratios.
  • 8.
  • 9. Test cross F1 to double recessive: Parents PpLl X ppll Gametes PL pl Pl pL pl Expect 1:1:1:1 ratio of phenotypes Bateson and Punnett observed 7:1:1:7 Some gamete types more common that others…but why???
  • 10.
  • 11.
  • 12.
  • 13.
  • 14.
  • 15.
  • 16.
  • 17.
  • 19. Peter J. Russell, iGenetics : Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. Mechanism of crossing-over
  • 23.
  • 24.
  • 25.
  • 26.
  • 27. Single Crossovers: Non-crossover (Parental) and Crossover (Recombinant) Gametes What is the maximum % recombination?
  • 28.
  • 29.
  • 30. Genetic Map of Drosophila melanogaster
  • 31.